<i>HLA‐DQB1*0301</i> association with increased cutaneous melanoma risk

Lee, Jeffrey E.; Reveille, John D.; Ross, Merrick I.; Platsoucas, Chris D.

doi:10.1002/ijc.2910590413

Cited by 80 publications

(74 citation statements)

References 24 publications

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“…Furthermore the gene frequency of HLA-DQβ1*0301 in our melanoma population was not significantly different from the frequency reported for the NAC population (22) (20 versus 16%). We therefore could not confirm the higher frequency of the HLA-DQβ1*0301 allele reported by Lee et al (7) in melanoma patients (56%, n = 45), compared with normal controls (27%, n = 200, p = 0.002).…”

Section: Resultsmentioning

confidence: 59%

HLA Associations in the Antitumor Response Against Malignant Melanoma

Marincola

Shamamian²,

Rivoltini³

et al. 1995

Journal of Immunotherapy

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SummaryIn this study we analyzed the human leukocyte antigen (HLA) pattern of North American Caucasian patients with metastatic melanoma as compared with the North American Caucasian (NAC) population. We also investigated whether the HLA type of melanoma patients had an effect on their tolerance and response to interleukin-2 (IL-2)-based therapy. Four hundred twelve serologic phenotypes of Caucasian melanoma patients referred to the National Cancer Institute, National Institutes of Health, from February 1989 through December 1993 were collected by typing the patient's peripheral blood lymphocytes. Furthermore, 74 melanoma patients were typed for HLA class II by high-resolution sequence specific primer-polymerase chain reaction. Response rate and treatment-related toxicity in those patients receiving IL-2-based treatment (N = 272) were compared with HLA serologic types. The frequency of four HLA-B alleles was significantly different in the melanoma compared with the NAC population: Of these, HLA-B5, -B8, and -B15 had a frequency falling between the NAC and the Northern European population. No other significant differences between melanoma patients and NAC population were noted for other HLA loci. A correlation was noted between HLA-DR3 and -DR4 alleles and decreased tolerance to IL-2, whereas homozygosity for HLA-DR decreased the chance of response. There were no significant associations between HLA type and response. It is unlikely that the associations noted between some HLA-B alleles and melanoma bear significantly on the etiology of the disease. The differences seen between American melanoma patients and the NAC population are probably best explained by geographical ancestry. The association between HLA-DR and tolerance to IL-2 therapy noted in this study may offer insight toward the understanding of mechanisms regulating the cascade of events after the systemic administration of IL-2. Keywords HLA; Malignant melanoma; NAC patientsSeveral associations between the prevalence pattern of a human leukocyte antigen (HLA) and a pathologic condition have been reported (1). The recognition of an association is presumed to (a) help prevention in a population at risk, (b) define a genetic linkage between a disease and a portion of the human genome that may shed light on etiological factors, and (c) have In this study we wanted to analyze possible associations between melanoma and HLA. Associations were explored between HLA frequencies in melanoma patients compared with the North American Caucasian (NAC) population with the caveat that, because melanoma occurs more commonly in people with light complexion of northern European ancestry, some differences could be due to the different ancestral origin of melanoma patients. Specifically, we studied HLA-B5, -B7, -B8, and -B15 alleles, whose distribution varies according to latitude in Europe (6), with the a priori hypothesis that their frequency in melanoma patients would fall in between the NAC and the Northern European population. Furthermore, because an increased risk of ...

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Section: Resultsmentioning

confidence: 59%

HLA Associations in the Antitumor Response Against Malignant Melanoma

Marincola

Shamamian²,

Rivoltini³

et al. 1995

Journal of Immunotherapy

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“…An MHC class II allele, DQBI *0301, has been shown to be significantly linked to the incidence of melanoma and advanced disease status (Lee et al, 1994), indicative of the association of cancer development with MHC class II genes. Our findings that HLA-DRBI *0101 and *0405 are protective alleles in patients with renal cell carcinoma (Ozdemir et al, 1997) is well established, with spontaneous regression of the RCC in some patients.…”

Section: Discussionmentioning

confidence: 99%

High-resolution HLA-DRB1 and DQB1 genotyping in Japanese patients with testicular germ cell carcinoma

Özdemir

Kakehi²,

Mishina³

et al. 1997

Br J Cancer

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Summary We report for the first time the frequency distributions of HLA-DRB1 and -DQB1 genes in 55 patients with testicular germ cell carcinoma (TGC) using the modified PCR-RFLP method and compare the results with those for 1216 healthy Japanese control subjects. The modified PCR-RFLP method produced accurate, reproducible cleavage patterns that are easily discriminated. HLA-DRB1*0410 was the susceptibility allele (RR = 3.26, P = 0.006) and DQB1 *0602 appears to be a candidate protective allele (RR = 0.26, P = 0.02) for TGC in the Japanese. None of the HLA-DRB1 and -DQB1 alleles showed a specific tendency for histological type or clinical stage of the tumours. Previous studies based on serotyping methods failed to show these allelic associations. High-resolution genotyping is essential because the peptide-binding domain of MHC class 11 molecules is determined more precisely by their genotypes than by their serotypes. In addition, inherent technical difficulties and typing errors of up to 25% make serotyping inefficient. Our results suggest that high-resolution genotyping is a useful genetic marker to determine risk for TGC.Keywords: testicular germ cell carcinoma; MHC class 11 genotyping; modified PCR-RFLP; allele frequency Testicular germ cell carcinoma (TGC), although relatively rare in the male population in general, is the most common malignancy in men between the ages of 15 and 35 years. Strong evidence for the involvement of genetic factors has been reported in TGC development. The incidence of TGC in first degree relatives is 2.2%, and in unrelated individuals 0.4%. For an individual who has a father or brother with TGC, the relative risk of developing TGC is increased sixfold compared with men in the general population. The concordance of tumour histology is high in twins and low in father-son pairs (Tolerud et al, 1985). Moreover, the incidence of TGC is relatively high among white American men in comparison with black American or Oriental men living in the same geographical areas

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“…These viruses are associated with adult T-cell leukemia and lymphoma. In cutaneous melanoma, an increased risk was reported for HLA-DQB1*0301 carriers (51). It is likely that HLA genes influence the development of virus-associated malignant diseases since these genes play a role in the regulation of the immune response against these viruses.…”

Section: Mhc Genes and Cervical Cancermentioning

confidence: 99%

Genetic susceptibility to HPV infection and cervical cancer

Maciag¹,

Villa²

1999

Braz J Med Biol Res

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Squamous cell carcinoma of the cervix (SCCC) is one of the leading causes of death in developing countries. Infection with high-risk human papillomavirus (HPV) is the major risk factor to develop malignant lesions in the cervix. Polymorphisms of the MHC and p53 genes seem to influence the outcome of HPV infection and progression to SCCC, although controversial data have been reported. MHC are highly polymorphic genes that encode molecules involved in antigen presentation, playing a key role in immune regulation, while p53 is a tumor suppressor gene that regulates cell proliferation. The HPV E6 protein from high-risk types binds p53 and mediates its degradation by the ubiquitin pathway. The role of these polymorphisms in genetic susceptibility to HPV infection and to SCCC remains under investigation.

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HLA‐DQB10301* association with increased cutaneous melanoma risk

Cited by 80 publications

References 24 publications

HLA Associations in the Antitumor Response Against Malignant Melanoma

HLA Associations in the Antitumor Response Against Malignant Melanoma

High-resolution HLA-DRB1 and DQB1 genotyping in Japanese patients with testicular germ cell carcinoma

Genetic susceptibility to HPV infection and cervical cancer

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HLA‐DQB1*0301 association with increased cutaneous melanoma risk

Cited by 80 publications

References 24 publications

HLA Associations in the Antitumor Response Against Malignant Melanoma

HLA Associations in the Antitumor Response Against Malignant Melanoma

High-resolution HLA-DRB1 and DQB1 genotyping in Japanese patients with testicular germ cell carcinoma

Genetic susceptibility to HPV infection and cervical cancer

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HLA‐DQB10301* association with increased cutaneous melanoma risk