<i>Histophilus somni</i> is a potential threat to beef cattle feedlots in Brazil

Headley, Selwyn Arlington; Alfieri, A.A.; Oliveira, Victor Henrique Silva de; Beuttemmuller, Edsel Alves

doi:10.1136/vr.102562

Cited by 27 publications

(39 citation statements)

References 18 publications

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“…During this study, concomitant bacterial infections due to M. haemolytica and P. multocida were detected in the lung of steers with bronchopneumonia, suggesting that these pathogens may be endemic at this feedlot. These results are quite different from those of other studies done in Brazil [9][10][11]49], and in beef cattle feedlots from Oklahoma, USA [39], Ontario, Canada [29], and in dairy herds from Quebec, Canada [50] in which there were coinfections with viral and bacterial pathogens and the viral pathogens probably predisposed the animals to a secondary bacterial disease. Therefore, we suggest that the bacterial pathogens at this feedlot were most likely associated with other stresses, such as vaccination and transport, since these pathogens were identified in steers that were less than 32 days-on feed.…”

Section: Discussioncontrasting

confidence: 56%

“…Although BRSV was identified in several feedlots from the state of Rio Grande do Sul [11], these authors only investigated the occurrence of this viral pathogen. Recently, our group has identified single and mixed associations of H. somni with bovine alphahepersvirus-1 in feedlot cattle with BRD from northern Paraná [9], and coinfections of H. somni with BRSV in feedlot cattle from the state of São Paulo [49]. We have also identified coinfections due to several disease agents such as BRSV, BVDV, BCoV, P. multocida, M. bovis, and H. somni in dairy cattle from the state of Paraná [10].…”

Section: Discussionmentioning

confidence: 99%

“…BRD is the most important cause of livestock mortality in the USA in feedlots and is responsible for 16% of all non-predator losses of beef cattle [8]. Data relative to the occurrence of BRD in Brazil is sparse, with Histophilus somni [9,10], the bovine respiratory syncytial virus, BRSV [10,11], bovine viral diarrhea virus (BVDV), bovine coronavirus (BCoV), Pasteurella multocida, and Mycoplasma bovis [10] being identified as the principal contributory agents. However, there is no data relative to the economic impacts of BRD on beef cattle feedlots from Brazil.…”

Section: Introductionmentioning

confidence: 99%

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Bovine respiratory disease complex associated mortality and morbidity rates in feedlot cattle from southeastern Brazil

Baptista

Rezende

Fonseca

et al. 2017

J Infect Dev Ctries

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Introduction: A feedlot is an intensive farming system for finishing livestock. Bovine respiratory disease (BRD) is a cause of morbidity and mortality in beef cattle, especially in feedlots. Methodology: This study investigated the morbidity and mortality of BRD in a beef cattle feedlot in southeastern Brazil using: clinical diagnoses, therapy, morbidity, and mortality. Pulmonary fragments were collected from five steers, on feed from 3-32 days, with lesions of pneumonia for identification of BRD infectious agents PCR. Results: 188,862 steers were on feed and morbidity was 7.05% (13,315/188,862), mortality 0.64% (1,214/188,862). The causes of morbidity were: BRD (6.13%), lameness (0.29%), trauma (0.21%), clostridiosis (0.13%) and polioencephalomalacia, PEM (0.12%). The causes of mortality were: BRD (0.21%), trauma (0.17%), and clostridiosis (0.13%). When all sick cattle were considered (n=13,315), BRD (86.9%) was the principal cause of morbidity, followed by lameness (4.13%), trauma (3.05%), and clostridiosis (1.82%). The cost of BRD-associated cattle mortality and morbidity was estimated at $14,334.00/10,000 and $16,315.40/10,000 respectively. It was projected that the economic effects due to BRD-associated morbidity in Brazil were $6.31 million/annum, while losses due to mortality were $5.54 million, resulting in an annual loss of $11.85 million. Coinfections in cattle with pneumonia due to Mannheimia haemolytica and Pasteurella multocida were identified in 4/5 steers tested. Conclusions: This is the first longitudinal study that investigated the incidence of BRD in feedlot cattle from Brazil, and the results herein described indicate that BRD contributed significantly to the development of mortality and morbidity of cattle on feed.

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Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bovine respiratory disease complex associated mortality and morbidity rates in feedlot cattle from southeastern Brazil

Baptista

Rezende

Fonseca

et al. 2017

J Infect Dev Ctries

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“…Consequently, these results indicate that BRSV and H. somni were involved in the development of the acute pulmonary distress in the animals evaluated at this feedlot, probably due to synergism identified between these two pathogens (AGNES et al, 2013). Moreover, this is one of the few studies done in Brazil that has effectively investigated the infectious agents associated with BRD in beef cattle feedlots; we have previously demonstrated H. somni and BoHV-1 associated with respiratory disease in a beef cattle feedlot (HEADLEY et al, 2014), and multiple infectious agents were associated with BRD in dairy cattle (OLIVEIRA, 2014). Although other groups only investigated and confirmed the participation of BRSV in cattle reared in feedlots (BRASIL et al, 2013) and extensively (DRIEMEIER et al, 1997;FLORES et al, 2000) from diverse regions of Brazil, it is rather likely that other infectious disease pathogens associated with BRD might have been identified if these were investigated.…”

Section: Discussionmentioning

confidence: 99%

“…Data relative to the occurrence of BRD in Brazil is sparse. We have theorized that H. somni might be a threat to beef cattle feedlots due to the continual diagnosis of this pathogen in respiratory (HEADLEY et al, 2014), reproductive (HEADLEY et al, 2015b), systemic (HEADLEY et al, 2013), and neurological (HEADLEY et al, 2015a) disease syndromes in cattle from different geographical regions of Brazil. Further, BRSV was associated with BRD in several herds from the state of Rio Grande do Sul, Southern Brazil (DRIEMEIER et al, 1997;BRASIL et al, 2013), while a retrospective study identified antigens of BRSV in cattle with bronchointerstitial pneumonia from Southern and Southeastern Brazil (FLORES et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Bovine respiratory disease associated with Histophilus somni and bovine respiratory syncytial virus in a beef cattle feedlot from Southeastern Brazil

Headley

Balbo

Alfieri

et al. 2017

SCA

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Bovine respiratory disease (BRD) is a complex multifactorial and multi-etiological disease entity that is responsible for the morbidity and mortality particularly in feedlot cattle from North America. Information relative to the occurrence of BRD in Brazil and the associated infectious agents are lacking. This study investigated the participation of infectious agents of BRD in a beef cattle feedlot from Southeastern Brazil. Nasopharyngeal swabs of 11% (10/90) of cattle (n, 450) with clinical manifestations of respiratory distress were analyzed by targeting specific genes of the principal infectious pathogens of BRD. In addition, pulmonary fragments of one the animals that died were collected for histopathological and molecular diagnoses. The nucleic acids of Histophilus somni and bovine respiratory syncytial virus (BRSV) were identified in 20% (2/10) of the nasopharyngeal swabs of the animals with respiratory distress; another contained only BRSV RNA. Moreover, the nucleic acids of both infectious agents were amplified from the pulmonary fragments of the animal that died with histopathological evidence of bronchopneumonia and interstitial pneumonia; the nasopharyngeal swab of this animal also contained the nucleic acids of both pathogens. Additionally, all PCR and/or RT-PCR assays designed to detect the specific genes of Mannheimia haemolytica, Pasteurella multocida, Mycoplasma bovis, bovine viral diarrhea virus, bovine herpesvirus -1, bovine parainfluenza virus-3, and bovine coronavirus yielded negative results. Phylogenetic analyses suggest that the isolates of H. somni circulating in Brazil are similar to those identified elsewhere, while there seem to be diversity between the isolates of BRSV within cattle herds from different geographical locations of Brazil.

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Association of Histophilus somni with spontaneous abortions in dairy cattle herds from Brazil

Headley

Voltarelli

Oliveira

et al. 2014

Trop Anim Health Prod

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This study investigated the participation of infectious agents in spontaneous abortions and reproductive problems at eight dairy cattle herds from three geographical regions of Brazil. Fourteen aborted fetuses and the organ sections of one cow with history of repeated abortions were received for pathological evaluations and molecular diagnostics. PCR/RT-PCR assays targeted specific genes of abortifacient agents of cattle: bovine viral diarrhea virus (BVDV), bovine herpesvirus 1 (BoHV-1), Listeria monocytogenes, Neospora caninum, Leptospira spp., Brucella abortus, and Histophilus somni. Six fetuses were adequate for pathological investigations; one of these did not demonstrate remarkable pathological alterations. Significant histopathological findings included vasculitis, hemorrhage, and fibrinous thrombosis of the cerebrum (n = 4); necrotizing myocarditis (n = 3); and hemorrhagic enteritis (n = 3). The placenta and uterus of the cow as well as the kidney, pancreas, and liver of her aborted fetus contained H. somni DNA and demonstrated histopathological evidence of histophilosis. All fetuses contained H. somni DNA in multiple organs. Coinfections of H. somni with B. abortus (n = 2), N. caninum (n = 2), BVDV (n = 1), and BoHV-1 (n = 1) were identified; two fetuses demonstrated three pathogens. These findings suggest that H. somni was associated with the spontaneous abortions and reproductive problems of these herds. However, the exact cause of fetal death might not be attributed only to H. somni in all aborted fetuses, since some of these were infected with other abortifacient agents.

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Histophilus somni is a potential threat to beef cattle feedlots in Brazil

Cited by 27 publications

References 18 publications

Bovine respiratory disease complex associated mortality and morbidity rates in feedlot cattle from southeastern Brazil

Bovine respiratory disease complex associated mortality and morbidity rates in feedlot cattle from southeastern Brazil

Bovine respiratory disease associated with Histophilus somni and bovine respiratory syncytial virus in a beef cattle feedlot from Southeastern Brazil

Association of Histophilus somni with spontaneous abortions in dairy cattle herds from Brazil

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