<i>Himatanthus bracteatus</i> stem extracts present anti-flavivirus activity while an isolated sesquiterpene glucoside present only anti-Zika virus activity <i>in vitro</i>

Silva, Marlene Lourenço da; Stehmann, João Renato; Serafim, Mateus Sá Magalhães; Vale, Valdicley Vieira; Gontijo, Douglas Costa; Brandão, Geraldo Célio; Kroon, Erna Geessien; Oliveira, Alaı́de Braga de

doi:10.1080/14786419.2019.1690487

Cited by 7 publications

(4 citation statements)

References 20 publications

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“…DC.) Woodson ( H. bracteatus ) is a species popularly used as a pro-healing natural product [ 13 ]. Previous research reports a variety of biological properties of extracts of several species of the Himatanthus genus that can contribute to improve wound healing, such as antioxidant and anti-inflammatory [ 14 ], analgesic [ 15 ], and antimicrobial [ 16 ], suggesting a biomedical potential for this plant.…”

Section: Introductionmentioning

confidence: 99%

Himatanthus bracteatus-Composed In Situ Polymerizable Hydrogel for Wound Healing

Almeida

Santos

Carvalho

et al. 2022

IJMS

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The Himatanthus genus presents anti-inflammatory, antioxidant activities, suggesting potential wound-healing properties. This study aimed to develop and analyze the wound-healing properties of a photopolymerizable gelatin-based hydrogel (GelMA) containing an ethanolic extract of Himatanthus bracteatus in a murine model. The extract was obtained under high pressure conditions, incorporated (2%) into the GelMA (GelMA-HB), and physically characterized. The anti-inflammatory activity of the extract was assessed using a carrageenan-induced pleurisy model and the GelMA-HB scarring properties in a wound-healing assay. The extract reduced IL-1β and TNF-α levels (48.5 ± 6.7 and 64.1 ± 4.9 pg/mL) compared to the vehicle (94.4 ± 2.3 pg/mL and 106.3 ± 5.7 pg/mL; p < 0.001). GelMA-HB depicted significantly lower swelling and increased resistance to mechanical compression compared to GelMA (p < 0.05). GelMA-HB accelerated wound closure over the time course of the experiment (p < 0.05) and promoted a significantly greater peak of myofibroblast differentiation (36.1 ± 6.6 cells) and microvascular density (23.1 ± 0.7 microvessels) on day 7 in comparison to GelMA (31.9 ± 5.3 cells and 20.2 ± 0.6 microvessels) and the control (25.8 ± 4.6 cells and 17.5 ± 0.5 microvessels) (p < 0.05). In conclusion, GelMA-HB improved wound healing in rodents, probably by modulating the inflammatory response and myofibroblastic and microvascular differentiation.

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Section: Introductionmentioning

confidence: 99%

Himatanthus bracteatus-Composed In Situ Polymerizable Hydrogel for Wound Healing

Almeida

Santos

Carvalho

et al. 2022

IJMS

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“…The ethanolic extract of Himatanthus bracteatus showed low cytotoxicity in Vero cells (CC 50 = 348.02 ± 5.75 μg/mL) and significant activity against ZIKV, yellow fever virus and Dengue virus sorotype 2 (DENV-2) (EC 50 = 31.46 ± 0.72, 17.43 ± 3.90 and 25.03 ± 1.20 μg/mL, respectively) with SI > 10, whereas the n -hexanic extract was inactive against the assayed viruses (SILVA et al, 2019) [ 73 ]. The sesquiterpene glycoside plumieride, the major constituent of H. bracteatus , was active against ZIKV (EC 50 = 14.49 ± 0.72 μg/mL and SI = 15.97) [ 73 ].…”

Section: Nps With Potential Anti-zikv Activitymentioning

confidence: 99%

Natural Products and Derivatives as Potential Zika virus Inhibitors: A Comprehensive Review

Pereira

Santos

Campana

et al. 2023

Viruses

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Zika virus (ZIKV) is an arbovirus whose infection in humans can lead to severe outcomes. This article reviews studies reporting the anti-ZIKV activity of natural products (NPs) and derivatives published from 1997 to 2022, which were carried out with NPs obtained from plants (82.4%) or semisynthetic/synthetic derivatives, fungi (3.1%), bacteria (7.6%), animals (1.2%) and marine organisms (1.9%) along with miscellaneous compounds (3.8%). Classes of NPs reported to present anti-ZIKV activity include polyphenols, triterpenes, alkaloids, and steroids, among others. The highest values of the selectivity index, the ratio between cytotoxicity and antiviral activity (SI = CC50/EC50), were reported for epigallocatechin gallate (SI ≥ 25,000) and anisomycin (SI ≥ 11,900) obtained from Streptomyces bacteria, dolastane (SI = 1246) isolated from the marine seaweed Canistrocarpus cervicorni, and the flavonol myricetin (SI ≥ 862). NPs mostly act at the stages of viral adsorption and internalization in addition to presenting virucidal effect. The data demonstrate the potential of NPs for developing new anti-ZIKV agents and highlight the lack of studies addressing their molecular mechanisms of action and pre-clinical studies of efficacy and safety in animal models. To the best of our knowledge, none of the active compounds has been submitted to clinical studies.

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“…The fraction of plumeria molecule was found active only against Zika virus. 38 Lupeol isolated from Carissa edulis has shown significant viricidal activity against Herpes simplex virus types-1 by reducing viral yields in Vero E6 cells. 39 Potent antiviral activity against HIV-1 at 6 μg/mL, sindbis virus at 3 μg/ mL, poliovirus, and herpes simplex virus at 12 μg/mL was shown by the ethanolic extract of Carissa carandas fruits.…”

Section: Potential Phytochemicals For Covid-19 Managementmentioning

confidence: 99%

Therapeutic Potential of Traditional Indian Herbal Medicine in COVID-19: A Narrative Review

et al. 2021

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Background: Coronavirus disease 2019 (COVID-19) has become a global challenge to the health care system. A novel agent to combat this deadly virus is still a matter of research. Herbal molecules have served humanity since the beginning. Objectives: This narrative review aims to study the antiviral properties of medicinal plants, which are already effectively used in the past against various viruses. It derives the importance of exploration of such phytochemicals, which can be complementarily used to treat COVID-19. Methods: Studies related to traditional medicine and treatment for viruses were retrieved from databases including PubMed, Google scholar until December 2020 using the keywords SARS-CoV-2, COVID-19, Immunological, Phyto-chemicals, Traditional Medicine. The resulting publications were analyzed to develop a narrative review on the traditional Indian phytochemicals that have been shown to effectively treat various viral infections and potentially treat or prevent COVID-19. Results: Many of the researches are showing that Indian herbal compounds have a significant potential against viral diseases. Plants like Azadirachta indica, Withania somnifera, Tinospora cordifolia, Ocimum basilicum, and many more have been shown tremendous antiviral, anti-inflammatory, and immune-modulatory activities. Conclusion: Phytochemicals obtained from the herbs can be helpful in the treatment and prevention of SARS-CoV-2via various modes such as inhibition of attachment, penetration, uncoating, replication, assembly, and release of respiratory viruses. Further analysis of the potential phytochemicals in treating SARS-CoV-2 in clinical trials is warranted.

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Himatanthus bracteatus stem extracts present anti-flavivirus activity while an isolated sesquiterpene glucoside present only anti-Zika virus activity in vitro

Cited by 7 publications

References 20 publications

Himatanthus bracteatus-Composed In Situ Polymerizable Hydrogel for Wound Healing

Himatanthus bracteatus-Composed In Situ Polymerizable Hydrogel for Wound Healing

Natural Products and Derivatives as Potential Zika virus Inhibitors: A Comprehensive Review

Therapeutic Potential of Traditional Indian Herbal Medicine in COVID-19: A Narrative Review

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