<i>Herpesvirus cyprini</i>: a search for viral genome in infected fish by infected fish by <i>in situ</i> hybridization

Sano, Natsumi; Moriwake, M.; Hondo, Ryo; Sano, Tokuo

doi:10.1111/j.1365-2761.1993.tb00883.x

Cited by 47 publications

(45 citation statements)

References 6 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, latent CyHV-1 persists in carp that survive infection (41), and AngHV-1 persists in surviving infected eels (38,47). In these cases, the viral genome was found in cranial nerve cells and spinal nerves by using in situ hybridization (31,41,42). It would be interesting to determine whether the pathogenic and attenuated CNGV and CyHV-2 also persist in nerves of survivors.…”

Section: Latencymentioning

confidence: 99%

Characterization of a Novel Virus Causing a Lethal Disease in Carp and Koi

Ilouze¹,

Dishon²,

Kotler³

2006

Microbiol Mol Biol Rev

View full text Add to dashboard Cite

SUMMARY Since 1998 a lethal disease of carp and ornamental koi (Cyprinus carpio) has afflicted fisheries in North America, Europe, and Asia, causing severe economic losses to the fish farming industry. This review summarizes the isolation and identification of the disease-causing agent and describes the currently known molecular characteristics of this newly isolated virus, distinguishing it from other known large DNA viruses. In addition, we summarize the clinical and histopathological manifestations of the disease. Providing information on the immune response to this virus and evaluating the available means of diagnosis and protection should help to reduce the damage induced by this disease. This review does not discuss the economic aspects of the disease or the debate on whether the disease should be registered; both of these issues were recently reviewed in detail (O. L. M. Haenen, K. Way, S. M. Bergmann, and E. Ariel, Bull. Eur. Assoc. Fish Pathol. 24:293-307, 2004; D. Pokorova, T. Vesely, V. Piackova, S. Reschova, and J. Hulova, Vet. Med. Czech. 50:139-147, 2005).

show abstract

Section: Latencymentioning

confidence: 99%

Characterization of a Novel Virus Causing a Lethal Disease in Carp and Koi

Ilouze¹,

Dishon²,

Kotler³

2006

Microbiol Mol Biol Rev

View full text Add to dashboard Cite

show abstract

“…The best evidence comes from studies of the Lucké tumor, in which RaHV1 nucleic acid and proteins have been demonstrated in non-infectious, virus-free tumor tissue that, upon temperature manipulation, can yield infectious virus (Biggs 1972, Naegele & Granoff 1980, Tweedell 1989. Moreover, evidence for a long-term carrier state, which may or may not involve latency, has been described in several fish HVs, including IcHV1 (Wise et al 1985, Boyle & Blackwell 1991, Baek & Boyle 1996, Gray et al 1999, Thompson et al 2005, SalHV2 (Gou et al 1991, Kimura & Yoshimizu 1998), CyHV1 (Sano et al 1993), AngHV1 (van Nieuwstadt et al 2001, Shih 2004, and CyHV3 (Adkison et al 2005, Bercovier et al 2005, St-Hilaire et al 2005. These reports, and others of an anecdotal nature, indicate the existence of long-term infections (perhaps latency) caused by a wide selection of viruses in the family Alloherpesviridae.…”

Section: Discussionmentioning

confidence: 99%

Phylogenetic relationships in the family Alloherpesviridae

Waltzek¹,

Kelley²,

Alfaro³

et al. 2009

Dis. Aquat. Org.

127

146

View full text Add to dashboard Cite

Phylogenetic relationships among herpesviruses (HVs) of mammals, birds, and reptiles have been studied extensively, whereas those among other HVs are relatively unexplored. We have reconstructed the phylogenetic relationships among 13 fish and amphibian HVs using maximum likelihood and Bayesian analyses of amino acid sequences predicted from parts of the DNA polymerase and terminase genes. The relationships among 6 of these viruses were confirmed using the partial DNA polymerase data plus the complete sequences of the terminase, helicase, and triplex protein genes; the position of these viruses among all other sequenced HVs was also investigated using the complete terminase gene. The results established the monophyly of the fish and amphibian HVs (Alloherpesviridae) separate from the HVs of mammals, birds, and reptiles (Herpesviridae) and the single recognized HV of bivalve mollusks (Malacoherpesviridae) in the order Herpesvirales. Two major clades in the family Alloherpesviridae were recognized: one consisting of viruses from cyprinid and anguillid hosts and the other of viruses from ictalurid, salmonid, acipenserid, and ranid hosts. A comparison of virus and host phylogenies suggested that closely related HVs in this family may have coevolved with their hosts, whereas significant codiversification was not apparent for the more distantly related viruses.KEY WORDS: Alloherpesviridae · Fish herpesviruses · Frog herpesviruses · Phylogeny · Coevolution· DNA polymerase · Terminase Resale or republication not permitted without written consent of the publisherDis Aquat Org 84: [179][180][181][182][183][184][185][186][187][188][189][190][191][192][193][194] 2009 pesviridae, divided into the subfamilies Alphaherpesvirinae, Betaherpesvirinae, and Gammaherpesvirinae) containing mammalian, avian, and reptilian viruses, one (Alloherpesviridae) containing fish and amphibian viruses, and one (Malacoherpesviridae) containing a single virus, OsHV1. The taxonomic structure of the family Herpesviridae has been well established phylogenetically, and the viruses are characterized by approximately 43 homologous genes that were presumably inherited from a common ancestor (McGeoch et al. 2006). The erection of the 2 new families was driven by the findings that these viruses are but tenuously related to the fish and amphibian HVs, which share at least 13 homologous genes with each other (Aoki et al. 2007), and that OsHV1 is related only marginally to all other HVs (Davison et al. 2005b). Indeed, the best, and perhaps only, sequence-based evidence supporting a common ancestry for all HVs resides in a single gene, that encoding the putative ATPase subunit of terminase (hereafter terminase; an enzyme complex involved in packaging DNA into capsids), in which 5 regions are conserved (Davison 1992(Davison , 2002. This protein is also conserved to a lesser extent in T4-like bacteriophages in the family Myoviridae (Davison 1992). Indeed, the perceived utilization of a similar enzyme complex for packaging DNA into preformed capsids...

show abstract

“…Such papillomas coalesce as they spread over the surface of carp as white plaques, and develop focal exophytic masses (Wildgoose, 1992). These papillomas are caused by Herpesvirus cyprini (also cyprinid herpesvirus 1, CHV) (Sano et al, 1991), regress in warm summers or when held above 20°C (Sano et al, 1993b), and persist below 15°C (Sano et al, 1993a). Viruses have also been associated with papillary epidermal plaques in other fish species (Wolf, 1988), such as walleye, in which a retroviral etiology is suspected (LaPierre et al, 1998).…”

Section: Beckwith Et Almentioning

confidence: 99%

Ethylnitrosourea Induces Neoplasia in Zebrafish (Danio rerio)

Beckwith

Moore

Tsao-Wu

et al. 2000

Laboratory Investigation

View full text Add to dashboard Cite

SUMMARY:The zebrafish (Danio rerio) has been successfully used to discover hundreds of genes involved in development and organogenesis. To address the potential of zebrafish as a cancer model, it is important to determine the susceptibility of zebrafish to tumors. Germ line mutations are most commonly induced for zebrafish mutant screens by exposing adult male zebrafish to the alkylating agent, ethylnitrosourea (ENU). To determine whether ENU induces tumors, we compared the incidence of tumors in ENU-treated fish with untreated controls. Interestingly, 18 of 18 (100%) fish mutagenized with either 2.5 or 3.0 mM ENU developed epidermal papillomas, which numbered 1 to 22 per fish, within 1 year of treatment. The induced epidermal lesions included epidermal hyperplasia, flat papillomas (0.2 to 1.2 mm), and pedunculated papillomas (1.2 to 8 mm in greatest dimension), but no skin cancers. Angiogenesis was evident in papillomas larger than approximately 1 mm. All but two papillomas contained the three cell types (keratinocytes, club, and mucous cells) of normal zebrafish epidermis; histologic variants lacked either club cells or mucous cells. Two cavernous hemangiomas and a single malignant peripheral nerve sheath tumor were also found in the treated fish. None of five untreated controls developed tumors. These studies establish the feasibility of the zebrafish as an experimental model for the study of skin tumors. (Lab Invest 2000, 80:379-385).

show abstract

Herpesvirus cyprini: a search for viral genome in infected fish by infected fish by in situ hybridization

Cited by 47 publications

References 6 publications

Characterization of a Novel Virus Causing a Lethal Disease in Carp and Koi

Characterization of a Novel Virus Causing a Lethal Disease in Carp and Koi

Phylogenetic relationships in the family Alloherpesviridae

Ethylnitrosourea Induces Neoplasia in Zebrafish (Danio rerio)

Contact Info

Product

Resources

About