<i>Hericium erinaceus</i>, a medicinal fungus with a centuries-old history: Evidence in gastrointestinal diseases

Gravina, Antonietta Gerarda; Pellegrino, Raffaele; Auletta, Salvatore; Palladino, Giovanna; Brandimarte, Giovanni; D’Onofrio, Rossella; Arboretto, Giusi; Imperio, Giuseppe; Ventura, Andrea; Cipullo, Marina; Romano, Marco; Federico, Alessandro

doi:10.3748/wjg.v29.i20.3048

Cited by 9 publications

(4 citation statements)

References 145 publications

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“…Accordingly, we remain skeptical that the direct microbial approach using certain species, probiotics, or fecal microbiome transplants will effectively and permanently treat, or even heal, these chronic debilitating diseases ( 79 , 80 ). Finally, it should be emphasized that fungi ( 81 ) and intestinal virome ( 82 ) add further complexity to the field but remain to be investigated more extensively in the future.…”

Section: Discussionmentioning

confidence: 99%

Dysbiosis in inflammatory bowel diseases: egg, not chicken

Stange

2024

Front. Med.

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There is agreement that inflammatory bowel diseases are, both in terms of species composition and function, associated with an altered intestinal microbiome. This is usually described by the term “dysbiosis,” but this is a vague definition lacking quantitative precision. In this brief narrative review, the evidence concerning the primary or secondary role of this dysbiotic state is critically evaluated. Among others, the following facts argue against a primary etiological impact: 1) There is no specific dysbiotic microbiome in IBD, 2) the presence or absence of mucosal inflammation has a profound impact on the composition of the microbiome, 3) dysbiosis is not specific for IBD but linked to many unrelated diseases, 4) antibiotics, probiotics, and microbiome transfer have a very limited therapeutic effect, 5) the microbiome in concordant twins is similar to disease-discordant twins, and 6) the microbiome in relatives of IBD patients later developing IBD is altered, but these individuals already display subclinical inflammation.

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Section: Discussionmentioning

confidence: 99%

Dysbiosis in inflammatory bowel diseases: egg, not chicken

Stange

2024

Front. Med.

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“…In detail, it appears that H. erinaceus can promote a selection in the gut microbiota of SCFA-producing bacteria ( 34 ). This was observed in healthy volunteers subjected to a dry powder administration of this fungus with an increase in the gut microbiota of the relative abundance of Bifidobacterium and Bacteroides as well as SCFA-producing bacteria such as Roseburia faecis , Faecalibacterium prausnitzii , or Eubacterium rectale also reducing pathogenic strains (e.g., Streptococcus thermophilus or Roseburia intestinalis ) ( 10 ).…”

Section: Discussionmentioning

confidence: 99%

Hericium erinaceus, in combination with natural flavonoid/alkaloid and B3/B8 vitamins, can improve inflammatory burden in Inflammatory bowel diseases tissue: an ex vivo study

et al. 2023

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Hericium erinaceus, berberine, and quercetin are effective in experimental colitis. It is unknown whether they can ameliorate inflammatory bowel diseases in humans. This ex vivo study aimed to evaluate the anti-inflammatory potential of a nutraceutical compound of HBQ-Complex® (H. erinaceus, berberine, and quercetin), biotin, and niacin in inflammatory bowel disease patients. Tissue specimens were obtained either from Normal-Appearing Mucosa (NAM) or from Inflamed Mucosa (IM) in 20 patients with inflammatory bowel disease. mRNA and protein expression of COX-2, IL-10, and TNF-α were determined in NAM and IM biopsy samples (T0). IM samples were then incubated in HBQ-Complex® (with the addition of niacin and biotin), and COX-2, IL-10, and TNF-α tissue levels were evaluated at 120 minutes (T1) and 180 minutes (T2). Incubation with this compound resulted in a progressive decrease in gene and protein COX-2 and TNF-α expression at T1/T2 in the IM. IL-10 showed an opposite trend, with a progressive increase of mRNA and protein expression over the same time window. HBQ-Complex® (with the addition of niacin and biotin) decreased the expression of proinflammatory cytokines at the mRNA and protein levels in IBD tissue. On the contrary, mRNA and protein expression of the anti-inflammatory cytokine IL-10 showed a progressive increase.

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“…The mushroom Hericium erinaceus , mainly through its polysaccharide components, has traditionally and historically been used as a natural remedy for gastrointestinal disorders and epigastric pain. However, to the best of our knowledge, it has not been tested for use in treating SCD chronic pain [ 236 ]. H. erinaceus can regulate heat shock proteins (HSP70), which has the potential to offer beneficial health effects [ 237 ].…”

Section: Nutritional Perspectives In Sickle Cell Diseasementioning

confidence: 99%

Sickle Cell Disease Update: New Treatments and Challenging Nutritional Interventions

Bell,

Varzakas,

Psaltopoulou

et al. 2024

Nutrients

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Sickle cell disease (SCD), a distinctive and often overlooked illness in the 21st century, is a congenital blood disorder characterized by considerable phenotypic diversity. It comprises a group of disorders, with sickle cell anemia (SCA) being the most prevalent and serious genotype. Although there have been some systematic reviews of global data, worldwide statistics regarding SCD prevalence, morbidity, and mortality remain scarce. In developed countries with a lower number of sickle cell patients, cutting-edge technologies have led to the development of new treatments. However, in developing settings where sickle cell disease (SCD) is more prevalent, medical management, rather than a cure, still relies on the use of hydroxyurea, blood transfusions, and analgesics. This is a disease that affects red blood cells, consequently affecting most organs in diverse manners. We discuss its etiology and the advent of new technologies, but the aim of this study is to understand the various types of nutrition-related studies involving individuals suffering from SCD, particularly in Africa. The interplay of the environment, food, gut microbiota, along with their respective genomes collectively known as the gut microbiome, and host metabolism is responsible for mediating host metabolic phenotypes and modulating gut microbiota. In addition, it serves the purpose of providing essential nutrients. Moreover, it engages in direct interactions with host homeostasis and the immune system, as well as indirect interactions via metabolites. Nutrition interventions and nutritional care are mechanisms for addressing increased nutrient expenditures and are important aspects of supportive management for patients with SCD. Underprivileged areas in Sub-Saharan Africa should be accompanied by efforts to define and promote of the nutritional aspects of SCD. Their importance is key to maintaining well-being and quality of life, especially because new technologies and products remain limited, while the use of native medicinal plant resources is acknowledged.

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Hericium erinaceus, a medicinal fungus with a centuries-old history: Evidence in gastrointestinal diseases

Cited by 9 publications

References 145 publications

Dysbiosis in inflammatory bowel diseases: egg, not chicken

Dysbiosis in inflammatory bowel diseases: egg, not chicken

Hericium erinaceus, in combination with natural flavonoid/alkaloid and B3/B8 vitamins, can improve inflammatory burden in Inflammatory bowel diseases tissue: an ex vivo study

Sickle Cell Disease Update: New Treatments and Challenging Nutritional Interventions

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