HER2 oncogene amplification in extramammary Paget's disease

Abstract

These results indicate that HER-2 protein over-expression in EMP is common and due exclusively to gene amplification. They open up the possibility of HER2-targetted immunotherapy for patients with HER2+ disease.

Extramammary Paget's disease: analysis of growth signal pathway from the human epidermal growth factor receptor 2 protein

“…Although those investigators performed dual-color fluorescence in situ hybridization, no amplification was demonstrated. By contrast, Tanskanen et al [13] reported that 14 of 23 European cases (60.9%) demonstrated HER2 overexpression. In their series, HER2 amplification was seen in 10 of 14 HER2-overexpressing cases (71.4%).…”

“…This pathway leads to vigorous cell proliferation and is well known to contribute to growth of breast cancer [3][4][5][6] and mammary and extramammary Paget's disease [8][9][10][11][12][13]. The extracellular growth signals recognized by the HER2 growth factor receptor are transduced into the PI3K and ERK pathways by phosphorylation of AKT and ERK, respectively.…”

“…Studies of the HER2 growth pathway are limited in extramammary Paget's disease [13,34,35]. Takata et al [34] showed HER2 overexpression in none of 13 noninvasive, but in 10 of 13 invasive, tumors among 26 Japanese cases.…”

“…Several studies have shown frequent amplification of HER2, overexpression of HER2 protein, or both in mammary and extramammary Paget's disease [8][9][10][11][12][13]. However, there is no detailed study of the correlation between the HER2 signal pathway and clinicopathologic features in extramammary Paget's disease.…”

p185 overexpression and HER2 oncogene amplification in recurrent vulvar Paget's disease

“…[4][5][6][7][8][9] Tanskanen et al 5 reported HER2 oncogene amplification and p185 Her2 overexpression in seven of 13 primary vulvar Paget's disease, but p185 Her2 expression in recurrent Paget's disease has not been studied. We analyzed p185 Her2 overexpression and HER2 oncogene amplification in six patients with recurrent vulvar Paget's disease.…”