Helicobacter pylori infectionand related factors among pregnant women at Debre Tabor General Hospital, Northwest Ethiopia, 2021:Anemia highly related with H. pylori

Abstract

Introduction: Infection with Helicobacter pylori is one of the most frequent chronic bacterial illnesses in humans. Pregnant mothers are the populations most vulnerable to H. pylori infection. The objective of this study was to assess the prevalence of H. pylori infection and associated factors among pregnant mothers having antenatal care at Debre Tabor General Hospital, Debre Tabor, Ethiopia, 2021. Methods and materials: Institutional based cross-sectional study design was conducted on 290 pregnant women. The stool antigen test is used to detect the active presence of the H. pylori antigen in the feces. Bivariate and multivariable logistic regression analyses were carried out to assess potential factors responsible for H. pylori infection. Variables associated with the prevalence of H. pylori infection with ( p-value < 0.05) were considered statistically significant. Results: The prevalence of H. pylori infection was 17.9%, with 95% (CI: 13.4%–22.3%). In all, 65.4% of H. pylori infection positive mothers had gastrointestinal problems and developed symptoms like abdominal cramp and diarrhea 1 (1.92%), loss of appetite 10 (19.23%), hiccups 9 (17.31%), abdominal pain which worsens when the stomach is empty 19 (36.54%), indigestion, and frequent heart burn 13 (25%) during the present pregnancy. Lesser frequency of handwashing practice AOR = 3.09, 95% CI (1.14–8.34), use of soap for handwashing AOR = 0.44, 95% CI (0.19–0.98), eating unwashed vegetables and fruits AOR = 2.279, 95% CI (1.03–5.04), and not being anemic AOR = 0.268, 95% CI (0.10– 0.71), were significantly associated with H. pylori infection. Conclusions: This study shows that the prevalence of H. pylori infection among pregnant women was low compared with that of the general population. Although in the lower prevalence, the level of anemia was strongly associated with the prevalence of H. pylori infection. This implies that H. pylori infection is a public health problem.

Association between Hyperemesis Gravidarum in Iraqi Women with Helicobacter pylori Infection

“…Another study (18) showed a serum anti-H. pylori IgG antibody by ELISA > 1.1 was associated with hyperemesis gravidarum at a sensitivity of 86.67%, and a specificity of 65.91%.…”

“…The study included one hundred women during the first trimester of pregnancy from ALAlawia Teaching Hospital for Maternity in Iraq during the period from October 2021 until March 2022. Ages of total pregnancy ranged from (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) years. Total patients were divided into four groups as follows: Group one: Included 25 pregnant with severe vomiting.…”

The association between Helicobacter pylori and gastrointestinal disorders during pregnancy: A Multicenter retrospective study

“…Previous studies have reported that nausea and vomiting of pregnancy (NVP), hyperemesis gravidarum(HG), FD, and some gastrointestinal symptoms are related to H. pylori infection. [3][4][5] However, few studies have shown that H. pylori infection increases the risk of these comorbidities and gastrointestinal symptoms and is associated with adverse pregnancy outcomes. [3][4][5][6] The current guidelines have not recommended routine H. pylori detection for pregnant women.…”

“…[3][4][5] However, few studies have shown that H. pylori infection increases the risk of these comorbidities and gastrointestinal symptoms and is associated with adverse pregnancy outcomes. [3][4][5][6] The current guidelines have not recommended routine H. pylori detection for pregnant women. Our study retrospectively analyzed the data of 503 pregnant women from three large tertiary hospitals of China.…”

Potential Impact of Active H. pylori Infection-Related Metabolic Syndrome on Preeclampsia Among Pregnant Women [Letter]

“…By introducing several diagnostic approaches increases the detection of Hp-I. 2 Specifically, despite the advantages (easy to perform and rapid for Hp detection), SATs display several disadvantages. Because the principle of SAT is an antigen-antibody reaction, differences in antigens used for SAT in different geographic regions may cause heterogeneity of results; the diagnostic performances of different SATs are heterogeneous, and this could relate to the designs of the test like enzyme immunoassay and immunochromatographic assay (ICA) and for the selection of antibody, such as monoclonal antibody and polyclonal antibody.…”