<i>Helicobacter pylori</i>“Test‐and‐Scope” Strategy for Dyspeptic Patients

Gisbert, Javier P.; Jm, Pajares García

doi:10.1046/j.1523-5378.2000.00009.x

Cited by 21 publications

(23 citation statements)

References 98 publications

(118 reference statements)

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“…Las 3 aproximaciones a la dispepsia no investigada que se han mostrado más eficaces son la realización de una endoscopia inicial, el tratamiento empírico antisecretor y la denominada estrategia test and treat. Esta última opción consiste en la realización de una prueba «no invasiva» (que no precisa de una endoscopia) para H. pylori y el tratamiento erradicador consiguiente si se demuestra la infección 18,19 . La estrategia test and treat sería aplicable únicamente a pacientes dispépticos jóvenes (la edad de corte es variable, véase más adelante) y sin sín-tomas de alarma.…”

Section: Tabla 2 Indicaciones De Tratamiento De La Infección Por Heliunclassified

III Conferencia Española de Consenso sobre la infección por Helicobacter pylori

Gisbert¹,

Calvet²,

Bermejo³

et al. 2013

Gastroenterología y Hepatología

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Section: Tabla 2 Indicaciones De Tratamiento De La Infección Por Heliunclassified

III Conferencia Española de Consenso sobre la infección por Helicobacter pylori

Gisbert¹,

Calvet²,

Bermejo³

et al. 2013

Gastroenterología y Hepatología

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“…Symptomatic treatment, on the other hand, could be given to non-infected patients. The test-and-scope strategy 13, 14 —performing a test to detect H. pylori in all patients and endoscopy only in those who are shown to be infected—has been considered less useful and is therefore not applied in clinical practice. 13, 14 …”

Section: Introductionmentioning

confidence: 99%

Helicobacter Pylori “Test-and-Treat” Strategy for Management of Dyspepsia: A Comprehensive Review

Gisbert

Calvet

2013

Clinical and Translational Gastroenterology

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OBJECTIVES:Deciding on whether the Helicobacter pylori test-and-treat strategy is an appropriate diagnostic–therapeutic approach for patients with dyspepsia invites a series of questions. The aim present article addresses the test-and-treat strategy and attempts to provide practical conclusions for the clinician who diagnoses and treats patients with dyspepsia.METHODS:Bibliographical searches were performed in MEDLINE using the keywords Helicobacter pylori, test-and-treat, and dyspepsia. We focused mainly on data from randomized controlled trials (RCTs), systematic reviews, meta-analyses, cost-effectiveness analyses, and decision analyses.RESULTS:Several prospective studies and decision analyses support the use of the test-and-treat strategy, although we must be cautious when extrapolating the results from one geographical area to another. Many factors determine whether this strategy is appropriate in each particular area. The test-and-treat strategy will cure most cases of underlying peptic ulcer disease, prevent most potential cases of gastroduodenal disease, and yield symptomatic benefit in a minority of patients with functional dyspepsia. Future studies should be able to stratify dyspeptic patients according to their likelihood of improving after treatment of infection by H. pylori.CONCLUSIONS:The test-and-treat strategy will cure most cases of underlying peptic ulcer disease and prevent most potential cases of gastroduodenal disease. In addition, a minority of infected patients with functional dyspepsia will gain symptomatic benefit. Several prospective studies and decision analyses support the use of the test-and-treat strategy. The test-and-treat strategy is being reinforced by the accumulating data that support the increasingly accepted idea that “the only good H. pylori is a dead H. pylori”.

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“…This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited rial agents (8). The use of techniques based on monoclonal antibodies to evaluate fecal samples has improved the accuracy of the test (9,10).…”

Section: Introductionmentioning

confidence: 99%

Detection of Helicobacter pylori from Human Biological Samples (Feces) by Antigenic Screening and Culture

Guaman

Bayas-Morejón

Arcos

et al. 2018

Jundishapur J Microbiol

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Background: This research addressed the topic of timely diagnosis of Helicobacter pylori that is currently a problem for public health in Ecuador and worldwide. The prevalence of the pathogen has increased in the last decade, especially due to its direct participation in gastric cancer generation. Objectives: The present investigation was carried out to detect H. pylori in human stool samples by antigenic screening and culture. Methods: The methodology used in this study was direct and indirect analysis of patients with H. pylori infection symptoms. Overall, 50 stool samples were collected (16 from males and 34 from females) and transferred immediately to the laboratory; patients were excluded due to causes such as contamination or insufficient amounts of sample for the analysis. From these samples, antigenic screening and culture in plates were carried out using the Brucella blood agar selective medium under controlled conditions. The two methods were analysed using the Kappa coefficient. Results: After antigenic screening analysis, 25 samples (50%) were positive for H. pylori with four false positives for both genders. The culture results showed that 19 samples (38%) were positive with 32 isolates characteristic for H. pylori. After agreement analysis, the kappa index was 0.28 (discrete). Conclusions:The detection rate by antigenic screening was higher than that obtained by culture, this is mainly due to the lack of viable cells and the difficulty of adapting adequate isolation techniques.

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Helicobacter pylori“Test‐and‐Scope” Strategy for Dyspeptic Patients

Cited by 21 publications

References 98 publications

III Conferencia Española de Consenso sobre la infección por Helicobacter pylori

III Conferencia Española de Consenso sobre la infección por Helicobacter pylori

Helicobacter Pylori “Test-and-Treat” Strategy for Management of Dyspepsia: A Comprehensive Review

Detection of Helicobacter pylori from Human Biological Samples (Feces) by Antigenic Screening and Culture

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