<i>Helicobacter pylori</i> protein that binds to and activates platelet specifically reacts with sera of <i>H. pylori</i>-associated chronic immune thrombocytopenia

Takeuchi, Hiroaki; Islam, Jahirul; Kaneko, Ayami; Kimura, Asako; Sugiyama, Takashi; Oboshi, Wataru; Katayama, Hironori; Oishi, Taku; Fujieda, Mikiya; Morimoto, Norihito

doi:10.1080/09537104.2021.1945570

Cited by 7 publications

(5 citation statements)

References 19 publications

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“…Importantly, we show the strong positive correlation between elevation of circulating TFHs and desialylated platelets, supporting TFHs as a critical mediator in synergy to promote platelet desialylation. A recent study found that H. Pylori infection may lead to the upregulation of TFHs in gastritis patients ( 41 ), and several recent reports revealed an association between H. Pylori infection and the incidence of ITP ( 42 – 44 ). Hence, we speculate that H. Pylori may be related to the abnormally elevated TFHs in the infected individuals with ITP in the present study.…”

Section: Discussionmentioning

confidence: 99%

Association of Platelet Desialylation and Circulating Follicular Helper T Cells in Patients With Thrombocytopenia

et al. 2022

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Thrombocytopenia is a multifactorial condition that frequently involves concomitant defects in platelet production and clearance. The physiopathology of low platelet count in thrombocytopenia remains unclear. Sialylation on platelet membrane glycoprotein and follicular helper T cells (TFHs) are thought to be the novel platelet clearance pathways. The aim of this study was to clarify the roles of platelet desialylation and circulating TFHs in patients with immune thrombocytopenia (ITP) and non-ITP thrombocytopenia. We enrolled 190 patients with ITP and 94 patients with non-ITP related thrombocytopenia including case of aplastic anemia (AA) and myelodysplastic syndromes (MDS). One hundred and ten healthy volunteers were included as controls. We found significantly increased desialylated platelets in patients with ITP or thrombocytopenia in the context of AA and MDS. Platelet desialylation was negatively correlated with platelet count. Meanwhile, the circulating TFH levels in patients with thrombocytopenia were significantly higher than those of normal controls, and were positively correlated with desialylated platelet levels. Moreover, TFHs-related chemokine CXCL13 and apoptotic platelet levels were abnormally high in ITP patients. The upregulation of pro-apoptotic proteins and the activation of the MAPK/mTOR pathway were observed in the same cohort. These findings suggested that platelet desialylation and circulating TFHs may become the potential biomarkers for evaluating the disease process associated with thrombocytopenia in patients with ITP and non-ITP.

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Section: Discussionmentioning

confidence: 99%

Association of Platelet Desialylation and Circulating Follicular Helper T Cells in Patients With Thrombocytopenia

et al. 2022

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“…One hypothesis suggests that H. pylori may promote the interaction between von Willebrand factor and platelet surface glycoproteins Ib/IX through anti-H. pylori IgG and IgG receptors (FcgRIIA) [99]. Another theory is that Lpp20, a lipoprotein bound to the outer membrane of the bacterium, can form immune complexes with platelets to which the host immune system can respond and determine platelet activation [100]. Lpp20 is normally found in extracellular vesicles, which have been linked to the pathogenesis of atherosclerosis in H. pylori infections.…”

Section: H Pylori: Interaction With Platelets Aggregationmentioning

confidence: 99%

The Interplay between Helicobacter pylori and Gut Microbiota in Non-Gastrointestinal Disorders: A Special Focus on Atherosclerosis

Candelli,

Franza,

Cianci

et al. 2023

IJMS

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The discovery of Helicobacter pylori (H. pylori) in the early 1980s by Nobel Prize winners in medicine Robin Warren and Barry Marshall led to a revolution in physiopathology and consequently in the treatment of peptic ulcer disease. Subsequently, H. pylori has also been linked to non-gastrointestinal diseases, such as autoimmune thrombocytopenia, acne rosacea, and Raynaud’s syndrome. In addition, several studies have shown an association with cardiovascular disease and atherosclerosis. Our narrative review aims to investigate the connection between H. pylori infection, gut microbiota, and extra-gastric diseases, with a particular emphasis on atherosclerosis. We conducted an extensive search on PubMed, Google Scholar, and Scopus, using the keywords “H. pylori”, “dysbiosis”, “microbiota”, “atherosclerosis”, “cardiovascular disease” in the last ten years. Atherosclerosis is a complex condition in which the arteries thicken or harden due to plaque deposits in the inner lining of an artery and is associated with several cardiovascular diseases. Recent research has highlighted the role of the microbiota in the pathogenesis of this group of diseases. H. pylori is able to both directly influence the onset of atherosclerosis and negatively modulate the microbiota. H. pylori is an important factor in promoting atherosclerosis. Progress is being made in understanding the underlying mechanisms, which could open the way to interesting new therapeutic perspectives.

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“…The anti-CagA and/or anti-VacA antibodies react to platelets (cross-reaction), leading to platelet aggregation and destruction (22)(23)(24). Studies have proposed an alternative pathway for H. pylori induction of chronic ITP, namely the formation of an immune complex consisting of the H. pylori antigen Lpp20, H. pylori-specific antibodies, and platelets (5,25). These studies have shown that levels of H. pylori-specific antibodies (anti-Lpp20 antibodies) are significantly higher in responders than in non-responders.…”

Section: Figurementioning

confidence: 99%

“…The infection could be a crucial trigger in the development of platelet autoimmunity in ITP (4). Studies have shown that platelet recovery after Helicobacter pylori (H. pylori) eradication therapy may be due to cross-reactivity between anti-H. pylori antibodies and platelets, which affects physiological pathways such as the balance of regulatory Fcγ receptors (5)(6)(7)(8). Due to modified immune responses and the production of auto-reactive antibodies, ITP, and other autoimmune diseases frequently coexist.…”

Section: Introductionmentioning

confidence: 99%

Case report: A case of immune thrombocytopenia combined with Hashimoto's thyroiditis and Helicobacter pylori infection in a child

Yang¹,

Xiao²,

Li³

et al. 2023

Front. Pediatr.

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Immune thrombocytopenia (ITP) is one of the most prevalent acquired bleeding disorders in children, which is primarily characterized by a decrease in platelet count. It can be classified into two subtypes: primary ITP and secondary ITP. The underlying mechanisms causing ITP are complex and not fully comprehended. Helicobacter pylori (H. pylori) infections can lead to ITP and potentially trigger various autoimmune diseases. Furthermore, there is evidence of a correlation between thyroid disease and ITP. In this case report, we describe the case of an 11-year-old patient who presented with ITP, Hashimoto's thyroiditis (HT), and H. pylori infection. Following anti-H. pylori treatment and thyroxine supplementation, the child's platelet count increased compared to the previous count. The limitation of this report is that the platelet count of this child returned to normal after anti-H. pylori and thyroxine supplementation, so we cannot distinguish the effect of anti-H. pylori and thyroxine supplementation on the platelet count in this child. Despite this limitation, we still believe that early screening for thyroid function and H. pylori, as well as prompt eradication of H. pylori, along with thyroxine supplementation, may be beneficial in treating and improving the prognosis of children diagnosed with ITP.

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Helicobacter pylori protein that binds to and activates platelet specifically reacts with sera of H. pylori-associated chronic immune thrombocytopenia

Cited by 7 publications

References 19 publications

Association of Platelet Desialylation and Circulating Follicular Helper T Cells in Patients With Thrombocytopenia

Association of Platelet Desialylation and Circulating Follicular Helper T Cells in Patients With Thrombocytopenia

The Interplay between Helicobacter pylori and Gut Microbiota in Non-Gastrointestinal Disorders: A Special Focus on Atherosclerosis

Case report: A case of immune thrombocytopenia combined with Hashimoto's thyroiditis and Helicobacter pylori infection in a child

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