<i>Helicobacter pylori</i>might contribute to nonalcoholic fatty liver disease-related cardiovascular events by releasing prothrombotic and proinflammatory factors

Kountouras, Jannis; Polyzos, Stergios A.; Zavos, Christos; Deretzi, Georgia; Kountouras, Constantinos; Vardaka, Elisabeth; Katsinelos, Panagiotis; Tsiaousi, Elena; Grigoriadis, Nikolaos; Romiopoulos, Iordanis; Tzilves, Dimitrios; Giartza-Taxidou, Evangelia

doi:10.1002/hep.27168

Cited by 18 publications

(14 citation statements)

References 4 publications

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“…Since then, a train of clinical studies of the relationship between H. pylori infection and NAFLD were successively reported (Table 1; Takuma, 2011; Kountouras et al, 2014; Zhang et al, 2016). At the earliest, a study from Greece recruiting 28 patients with biopsy-confirmed NAFLD (15 with NAFL, and 13 with NASH) and 25 matched healthy controls found higher rates of anti- H. pylori IgG in NAFLD groups compared to control group ( p = 0.038) and H. pylori infection could independently predict NAFLD in logistic regression analysis.…”

Section: Epidemiology and Clinical Experimentsmentioning

confidence: 99%

The Possible Role of Helicobacter pylori Infection in Non-alcoholic Fatty Liver Disease

Cheng

et al. 2017

Front. Microbiol.

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Helicobacter pylori (H. pylori) which colonizes the stomach can cause a wide array of gastric disorders, including chronic gastritis, peptic ulcer, and gastric cancer. Recently, accumulating evidence has implicated H. pylori infection in extragastrointestinal diseases such as cardiovascular diseases, neurological disorders, and metabolic diseases. At the same time, many scholars have noted the relationship between H. pylori infection and non-alcoholic fatty liver disease (NAFLD). Despite the positive association between H. pylori and NAFLD reported in some researches, there are opposite perspectives denying their relationship. Due to high prevalence, unclear etiology and difficult treatment of NAFLD, confirming the pathogenicity of H. pylori infection in NAFLD will undoubtedly provide insights for novel treatment strategies for NAFLD. This paper will review the relationship between H. pylori infection and NAFLD and the possible pathogenic mechanisms.

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Section: Epidemiology and Clinical Experimentsmentioning

confidence: 99%

The Possible Role of Helicobacter pylori Infection in Non-alcoholic Fatty Liver Disease

Cheng

et al. 2017

Front. Microbiol.

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“…In a systematic review (5), we also reported an association be- Apart from its effect on fibrinogen levels, Hp could influence the development of CVD through many other mechanisms (2,4,5). For instance, Hp stimulates the expression of plasminogen activator inhibitor-1, a major player in CVD pathogenesis; Von Willebrand factor antigen is strongly associated with Hp-I, providing solid evidence that…”

Section: Helicobacter Pylori-related Chronic Hepatitis C Infection Anmentioning

confidence: 78%

“…In this regard, our series demonstrated that increased fibrinogen levels (a serum inflammatory marker mentioned by the authors (1) and an independent risk factor for CVD), are associated with Hp-I and can be significantly reduced by Hp eradication. Other relative follow-up studies also reported that Hp eradication is associated with modification of certain CVD clinical and biochemical parameters (2,4).…”

Section: Helicobacter Pylori-related Chronic Hepatitis C Infection Anmentioning

confidence: 86%

“…Apart from other infectious agents associated with CVD, mentioned by the authors (1), the widespread Helicobacter pylori infection (Hp-I) is strongly associated with chronic HCV liver disease in Europe and other ethnic populations and Hp eradication holds promise for the improvement of the long-term health condition of patients with chronic HCV infection (2,3). Moreover, a large body of evidence has linked Hp-I to CVD (2,4).…”

Section: Helicobacter Pylori-related Chronic Hepatitis C Infection Anmentioning

confidence: 99%

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Helicobacter pylori‐related chronic hepatitis C infection and the risk for cardiovascular disease

Kountouras

Polyzos

Zeglinas

et al. 2016

Liver International

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“…The most recent articles strengthened the link between cardiovascular disease and metabolic syndrome; in this setting, the role played by insulin resistance is widely accepted and several comparable pathogenic mechanisms have been described in H. pylori infection and insulin resistance syndrome …”

Section: Metabolic Syndromementioning

confidence: 99%

Helicobacter pylori infection and extragastric diseases in 2017

et al. 2017

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The huge variety of extragastric diseases linked to Helicobacter pylori infection is widely known, and new studies are conducted every year on this topic. Neurological disorders and metabolic syndrome are some of the main issues debated in the most recent literature. Articles on the association of H. pylori with skin diseases, inflammatory bowel diseases, immunologic impairment, kidney dysfunction, allergic asthma, and respiratory diseases have been published as well. In this perspective, eradication therapy for this infection could become a mandatory measure in prevention strategy.

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Helicobacter pylorimight contribute to nonalcoholic fatty liver disease-related cardiovascular events by releasing prothrombotic and proinflammatory factors

Cited by 18 publications

References 4 publications

The Possible Role of Helicobacter pylori Infection in Non-alcoholic Fatty Liver Disease

The Possible Role of Helicobacter pylori Infection in Non-alcoholic Fatty Liver Disease

Helicobacter pylori‐related chronic hepatitis C infection and the risk for cardiovascular disease

Helicobacter pylori infection and extragastric diseases in 2017

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