<i>Helicobacter pylori</i> Infection, Serum Pepsinogen Level and Gastric Cancer: A Case‐Control Study in Japan

Fukuda, Haruhiko; Saito, Daizo; Hayashi, Shuya; Hisai, Hiroyuki; Ono, Hiroyuki; Yoshida, Shigeaki; Oguro, Yanao; Noda, Takeshi; Sato, Toshiya; Katoh, Masaru; Terada, Masaaki; Sügimura, Takashi

doi:10.1111/j.1349-7006.1995.tb02989.x

Cited by 101 publications

(73 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We did not obtain information at base line on Helicobacter pylori infection (HP). Among Japanese, HP infection significantly increases the risk of stomach cancer (Blaser et al, 1993;Fukuda et al, 1995;Kikuchi et al, 1995;Watanabe et al, 1997). However, a previous prospective cohort study showed that HP infection significantly increased the risk of stomach cancer in males (RR=2.59, 95% CI=1.03 -6.50) but not in females (RR=0.99, 95% CI=0.36 -2.68) (Yamagata et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Dietary factors and stomach cancer mortality

et al. 2002

View full text Add to dashboard Cite

The present study examined the relationship between stomach cancer and the low intake of fresh fruit and vegetables and/or a high intake of pickled, preserved or salted foods and frequent use of cooking oil. During 139 390 person -year of follow-up of over 13 000 subjects, 116 died from stomach cancer. Using a Cox proportional hazards -regression analysis of relative risk (RR, 95% CI) controlling for age, sex, smoking and other dietary factors, a significant decline was found with a high consumption of green and yellow vegetables (RR=0.4, 95% CI=0.2 -0.9). Reductions of between 40 and 50% were also observed with a high consumption of fresh foods (fruit, cuttle fish, tofu, and potatoes), but these associations were not statistically significant. The risk was significantly increased by the high consumption of processed meat (RR=2.7, 95% CI=1.0-7.4) and by the frequent use of cooking oil (RR=4.0, 95% CI=1.3-11.8). The high consumption of pickled food and traditional soups also increased risk, but not significantly. The findings suggest that a diet high in salt and low in vitamins may be associated with an increase in stomach cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Dietary factors and stomach cancer mortality

et al. 2002

View full text Add to dashboard Cite

show abstract

“…Interestingly, patients with a short follow-up period were also found among the older patients in the H. pylori-negative group. Fukuda et al [28] suggested that H. pylori had already been eradicated in an older population with primary gastric cancer at the time of operation. Although we did not examine H. pylori prevalence before the operation, our data is in line with their observation.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Helicobacter pylori infection in gastric remnant after distal gastrectomy for primary gastric cancer

et al. 2001

View full text Add to dashboard Cite

therapy has improved, and a long postoperative life is usual in a majority of these patients with early-stage gastric carcinoma [1]. However, in these patients, the gastric remnant (GR) retains the mucosa that had been the background of the initial cancer, and the mucosa exists in nonphysiological circumstances. Thus, the possible development of a second primary cancer in the GR has been a problem. In practice, the incidence of a second primary cancer in the GR is considerably high. At our institute, second primary cancer in the GR was found in approximately 2% of the patients after curative resection of primary gastric carcinoma [2]. Thus, post-operative endoscopic surveillance has been emphasized to detect curable early-stage cancer in the GR [3].Our previous study demonstrated that the features of early-stage second primary cancer in the GR were somewhat different from those of ordinary primary gastric carcinoma; protruding lesions and intestinal type cancer were dominant, and the background mucosa of these lesions was often associated with atrophic gastritis or intestinal metaplasia [2,4]. Although the real cause of gastric carcinogenesis is not fully understood, several environmental factors, including infection with Helicobacter pylori, have been shown to be linked with gastric carcinogenesis [5]. Since Warren and Marshall [6] first isolated H. pylori from the stomachs of patients with gastritis, numerous studies have demonstrated the relationship between H. pylori infection and the development of gastric cancer [7][8][9][10]. Now, H. pylori is regarded as a definite carcinogen [11] and as a trigger for the sequence of carcinogenesis, because there is strong evidence for H. pylori infection as a cause of chronic atrophic gastritis and intestinal metaplasia, two possible precancerous lesions [9,10,[12][13][14]. Our previous observations on the background mucosa of early-stage carcinoma of the GR also indicated an intimate association between atrophic gastritis and intestinal-type gastric carcinoma [2]. Thus, involvement of H. pylori in carAbstract Background. The development of a second primary cancer in the gastric remnant after gastrectomy for early gastric carcinoma is a problem, and eradication of Helicobacter pylori after the operation has been recommended. However, to date, practical indications for H. pylori eradication after gastric cancer surgery have not yet been reported. Methods. We examined H. pylori infection in the gastric remnant after distal gastrectomy for primary gastric cancer. One hundred and nine patients who had had a gastrectomy were studied. Endoscopic findings and results from the urease test, bacteriologic assessment, serological test, and histopathological examination were analyzed. Results. Seventy-one patients (65.1%) were judged to be positive for H. pylori infection. The prevalence of H. pylori infection was found to be significantly decreased in older patients, patients in whom the operation had been performed a long time before examination, patients with symptoms, and pati...

show abstract

“…14,15) Such a trend could be explained by a decrease in H. pylori prevalence among those who were born later due to the steadily improving sanitary conditions.…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori risk associated with childhood home environment

Ueda

Kikuchi

Kasugai³

et al. 2003

Cancer Science

View full text Add to dashboard Cite

Helicobacter pylori (H. pylori) is considered to be a cause of gastric ulcer, gastric cancer and other diseases. The relationship between infection and the hygiene or housing circumstances of such patients in their childhood was explored. The study subjects were those who applied for a H. pylori antibody test, and were asked to fill out a questionnaire enclosed with a test kit, inquiring as to their hygiene and housing conditions when they were 10 years old. Of 5971 applicants, 5854 agreed to participate in the study. Associations between the six factors in the questionnaire and infection were calculated, and adjusted for sex, age and district. Drinking water, type of toilet, residential area, number of people in the house, and birth order showed significant correlations with H. pylori infection. The odds ratios (95% confidence intervals) were 0. elicobacter pylori (H. pylori) is frequently isolated from the gastric mucosa of patients with gastric ulcer, duodenal ulcer, and chronic gastritis. Persistent H. pylori infection leads to atrophy of the gastric mucosa, causes intestinal metaplasia, and also contributes to the onset of stomach cancer. 1-3)Numerous studies so far have suggested that H. pylori infection is related to factors such as the sanitary condition of tap and ground water, 4, 5) economic status, and ethnicity. 6, 7) H. pylori infection during adulthood is believed to be rare, and infection is often established during childhood. 8,9) The aim of this study was to assess the relationship between the establishment of infection and factors such as sanitary conditions or home environment during childhood. Relevant factors were the types of water supply and toilet, residential area, family size, breastfeeding and birth order. Subjects and MethodsSubjects were selected from those who underwent both a serum PG test and an H. pylori antibody test as part of a the so-called stomach cancer examination system by mail.A questionnaire was sent out with the application form. Of the 5971 subjects who responded, 5854 consented to participate in the research, and the results of their H. pylori antibody tests were collected.The H. pylori antibody was measured using dried blood on filter paper and delivery was by the Japanese postal service. The test system itself has been administered by the Aichi Medical Foundation of Diagnostic Technology since 1995.The questionnaire inquired about the environment of the subject at the age of 10 years, eliciting details about drinking water (natural/well/tap water), type of toilet (flush/other), residential area (rural/urban), family size (1-3/4-6/7 or more), birth order (1/2-3/4-5/6 or more) and breast feeding (breast milk/ other).Multiple logistic regression models were used to calculate odds ratios (ORs) of the factors. H. pylori infection (infected or not infected) was the criterion variable, and ORs of the factors adjusted for sex, age and district were calculated.In the next step, statistically significant factors were entered into a multiple logistic regression model together...

show abstract

Helicobacter pylori Infection, Serum Pepsinogen Level and Gastric Cancer: A Case‐Control Study in Japan

Cited by 101 publications

References 28 publications

Dietary factors and stomach cancer mortality

Dietary factors and stomach cancer mortality

Prevalence of Helicobacter pylori infection in gastric remnant after distal gastrectomy for primary gastric cancer

Helicobacter pylori risk associated with childhood home environment

Contact Info

Product

Resources

About