Helicobacter Pylori infection of the gallbladder and the risk of chronic cholecystitis and cholelithiasis: A systematic review and meta‐analysis

Abstract

Background: Helicobacter pylori is coexisted with various diseases, including chronic

Association betweenH. pyloriinfection and health Outcomes: an umbrella review of systematic reviews and meta-analyses

“…Overall, 3036 articles that met our search criteria were first identified from the seven databases. Sixty articles9–18 27–76 of observational studies were finally selected, covering 88 unique outcomes (figure 1). Fifty-four meta-analyses10–17 28–34 38–40 42–44 47–50 54–60 64–70 72–75 were reanalysed because they did not present all of the results of estimates (i.e.…”

“…Among the 1239 individual studies, 274 (22%) were cross-sectional studies, 748 (60%) were case–control studies, 124 (10%) were cohort studies and 93 (8%) were mentioned as observational studies. Furthermore, 1 meta-analysis62 did not present the number of participants, and 12 meta-analyses27 35 36 41 45 49 51 53 54 61–63 72 did not present the number of cases. Among the meta-analyses that indicated the number of cases or participants, the median number of cases was 1032 (28–96 753) and the median number of participants was 3826 (222–377 976).…”

Letter: Helicobacter pylori in proton pump inhibitor‐associated biliary disease

“…Bile stasis has primarily been connected with hepatobiliary Hp contamination, thus leading to a threefold risk of chronic lithiasis and cholecystitis, triggered by a perpetual inflammation of the gallbladder. 4,5 In this respect, our data indicated Hp presence in gallbladder tissue in 19.33% of patients who were submitted to cholecystectomy due to lithiasis, 6 while chronic biliary Hp-I has been identified in 75% of patients with gallbladder cancer. 7 The proposed routes of contamination, although unproved, include ascending migration through the sphincter of Oddi and haematogenous spread to the liver and then excretion into bile.…”

Current understanding and management of Helicobacter pylori infection: an updated appraisal

“…Cen et al ., in a meta-analysis comprising 18 studies involving 1,544 participants, found an overall threefold increased risk for gall bladder disease, such as cholecystitis and cholelithiasis, in association with H. pylori infection. In Asian populations, the risk is higher than in non-Asian populations 13 . Serological evidence for H. pylori infection was found to be associated with the development of hepatic diseases such as non-alcoholic fatty liver disease 14 .…”