Helicobacter pylori infection is an independent risk factor of early and advanced colorectal neoplasm

Abstract

In a large-scale study, carefully controlled for confounding factors, involving asymptomatic participants without a history of colonoscopy, H. pylori infection was significantly associated with the risk of any colorectal adenoma and advanced colorectal neoplasm. Prospective studies are necessary to determine whether H. pylori eradication can reduce this risk.

The association between Helicobacter pylori infection and the risk of advanced colorectal neoplasia may differ according to age and cigarette smoking

“…In the present study focusing on the association between H. pylori infection and ACN, patient with H. pylori infection had a modest increased risk of ACN compared to those without H. pylori infection which is consistent with the results of previous studies. 10,22 However, the association was limited to patients aged <50 years and significantly affected by smoking history.…”

Microbiota, Inflammation and Colorectal Cancer

“…The association between H. pylori infection and CRC is still controversial with studies showing a close link with a higher prevalence of H. pylori infection in patients with colonic adenomas and carcinomas [169,170,171,172], while others do not [173,174,175]. Recent studies released in 2017 have suggested indeed a significant association between H. pylori infection and an increase in CRC occurrence [176,177,178]. Yan and colleagues showed a positive association between H. pylori and CRC only when H. pylori is associated with intestinal metaplasia [178].…”

Age and gender may be the key points in hyperglycemic patients with Helicobacter pylori infection combined colorectal adenoma—author's reply

“…To the Editor, We appreciate the comment by Hu et al on our recently published article. 1 Our findings indicated that Helicobacter pylori infection was associated with an increased risk of colorectal neoplasia, including any adenoma and advanced neoplasia. 1 Hu et al emphasized the synergistic effect of hyperglycemia and H. pylori infection status on colorectal neoplasia risk.…”

“…1 Our findings indicated that Helicobacter pylori infection was associated with an increased risk of colorectal neoplasia, including any adenoma and advanced neoplasia. 1 Hu et al emphasized the synergistic effect of hyperglycemia and H. pylori infection status on colorectal neoplasia risk. 2 We additionally evaluated the impact of glycemic status and H. pylori infection on the risk of colorectal neoplasia in our cohort.…”