<i>Helicobacter pylori</i> Infection in Connective Tissue Disorders is Associated with High Levels of Antibodies to Mycobacterial hsp65 but not to Human hsp60

Kopper, László; Fekete, B.; Czirják, László; Horváth, Laura; Daha, Mohamed R.; Veres, Amarilla; Fónyad, Gábor; Horváth, Anna; Viczián, Á.; Singh, Mahavir; Hoffer, I.; Füst, George; Romics, L; Prohászka, Zoltán

doi:10.1046/j.1523-5378.2002.00092.x

Cited by 45 publications

(30 citation statements)

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“…Pylori antibodies have been found to have the highest prevalence in SLE and undifferentiated connective tissue diseases [7]. Another study has shown that giant cell arteritis, SSc and PBC increased the prevalence of anti-H. Pylori antibodies [8].…”

Section: H Pylorı and Slementioning

confidence: 99%

The Relationship of Systemic Lupus Erythematosus and Helicobacter Pylori

Yıldırım¹,

Yıldırım²

2015

Med-Science

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Systemic lupus erythematosus (SLE) is an inflammatory disease of unknown etiology. In the pathogenesis of SLE, several infectious agents have been held responsible such as cytomegalovirus, parvovirus B19 and Epstein Barr virus (EBV). There is a variable relationship between SLE and helicobacter, which is different from that of lupus and other infections. We would like to emphasize the interrelation between these entities.

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Section: H Pylorı and Slementioning

confidence: 99%

The Relationship of Systemic Lupus Erythematosus and Helicobacter Pylori

Yıldırım¹,

Yıldırım²

2015

Med-Science

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“…In an animal study, it was found that exposure to H.pylori urease can lead to production of anti-single stranded DNA antibodies [39]. Kalabay and colleagues studied the prevalence of anti-H.pylori antibodies in various autoimmune rheumatic diseases and they found the comparable prevalence of H.pylori in SLE patients and healthy controls [40]. Showji et al showed that the titers of anti-H.pylori antibodies were lower in SLE than other autoimmune diseases [41].…”

Section: Discussionmentioning

confidence: 99%

Association of Helicobacter pylori Infection with Systemic Lupus Erythematosus

Ejtehadi¹,

Roghanian²,

Bonakdar³

2017

J Clin Cell Immunol

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Objective: Systemic Lupus Erythematosus (SLE) is an autoimmune disease of unknown etiology. However, a complex combination of host and environmental factors are believed to play a pivotal role. In the pathogenesis of SLE, several infectious agents have been held responsible such as Cytomegalovirus, Parvovirus B19, Epstein Barr virus and Retrovirus. There is a variable relationship between SLE and Helicobacter, which is different from that of lupus and other infections. The aim of this study was to investigate the association between Helicobacter pylori (H.pylori) infection and SLE development. Method:In this study, 82 serum samples and 65 stool samples were collected from the SLE patients as well as the control group, respectively. An enzyme-linked immunosorbent assay (ELISA) was used to detect the presence of specific IgG/IgM antibodies against H.pylori in all serum samples. The presence of H.pylori antigen was examined in all stool samples by using stool antigen test. Suitable statistical analysis was applied.Results: Thirteen (15.9%) out of 82 SLE patients and 30 (36.6%) out of 82 control group were anti-H.pylori IgM seropositive. There was a significant difference between the level of IgM in SLE patients and control group (p<0.05). Anti-H.pylori IgG antibodies were present in 37 (45.1%) of SLE patients and in 41 (50%) of the control group without any significant difference. Regarding stool antigen examination, there were 24 (36.9%) and 26 (42/6%) positive samples among the SLE patients and control group, respectively. There was no significant difference between the patients and controls samples in the number of stool antigen test positive samples (p>0.05). Conclusions:Based on data obtained in this study, it is concluded that there was a significant difference between the number of IgM seropositive in SLE patients and control group, which shows that SLE disease may have an inhibitory role in H.pylori infection occurance.

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“…A case report of SSc following human Cytomegalovirus (HCMV) infection in 2002 has been described [50]; moreover, a crossreaction of the UL70 protein of HCMV and Scl 70, which are characteristic of diffuse SSc, has been suggested [51]. Helicobacter Pylori (HP) has been detected in very high percentage of SSc patients [52,53]. Bilgin et al [37] in 2015 reported higher prevalence of HP, CMV, EBV, and parvovirus B19 in 30 patients with SSc compared with healthy controls.…”

Section: Low Vitamin D Level Infections and Systemic Sclerosismentioning

confidence: 99%