<i>Helicobacter pylori</i> infection appears the prime risk factor for stomach cancer

Tokudome, Shinkan; Ghadimi, Reza; Suzuki, Sadao; Hosono, Akihiro; Tanaka, Tsutomu; Arakawa, Kazuyuki; Zhao, Yupei; Hattori, Nami; Agawa, Hiroyuki; Marumoto, Mitsuhiro; Ando, Ryosuke; Moore, Malcolm A

doi:10.1002/ijc.22223

Cited by 8 publications

(5 citation statements)

References 7 publications

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“…48 The negative association we observed between height and death from gastric cancer is consistent with the known relevance to this malignancy of Helicobacter pylori infection, acquisition of which is related to poorer socio-economic circumstances in childhood. 15,49 Our study of over 1 million adults was powerful, involved individual participant data, adjusted for several major risk factors, assessed risk factors serially in 355 000 participants and studied a wide range of common and less common disease outcomes in a standardized manner. Since we analysed only prospective cohort studies, we minimized potential biases.…”

Section: Discussionmentioning

confidence: 99%

Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis

Wormser¹,

Angelantonio²,

Kaptoge³

et al. 2012

International Journal of Epidemiology

222

122

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Section: Discussionmentioning

confidence: 99%

Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis

Wormser¹,

Angelantonio²,

Kaptoge³

et al. 2012

International Journal of Epidemiology

222

122

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“…This organism has been causally linked to a majority of stomach ulcers [62] and is now considered a serious risk factor for both gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma [63]. Interestingly, immune responses to H. pylori recruit macrophages, DCs and T cells (with a strong Th17 component) to the site of infection [64], and patients with gastric carcinomas have been shown to have enhanced levels of Th17 cells in tumor-draining lymph nodes [65].…”

Section: Discussionmentioning

confidence: 99%

Extracellular ATP and Toll-Like Receptor 2 Agonists Trigger in Human Monocytes an Activation Program That Favors T Helper 17

et al. 2013

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Strategically-paired Toll-like receptor (TLR) ligands induce a unique dendritic cell (DC) phenotype that polarizes Th1 responses. We therefore investigated pairing single TLR ligands with a non TLR-mediated danger signal to cooperatively induce distinct DC properties from cultured human monocytes. Adenosine triphosphate (ATP) and the TLR2 ligand lipoteichoic acid (LTA) selectively and synergistically induced expression of IL-23 and IL-1β from cultured monocytes as determined by ELISA assays. Flow cytometric analysis revealed that a sizable sub-population of treated cells acquired DC-like properties including activated surface phenotype with trans-well assays showing enhanced migration towards CCR7 ligands. Such activated cells also preferentially deviated, in an IL-23 and IL-1-dependent manner, CD4pos T lymphocyte responses toward the IL-22hi, IL-17hi/IFN-γlo Th17 phenotype in standard in vitro allogeneic sensitization assays. Although pharmacological activation of either ionotropic or cAMP-dependent pathways acted in synergy with LTA to enhance IL-23, only inhibition of the cAMP-dependent pathway antagonized ATP-enhanced cytokine production. ATP plus atypical lipopolysaccharide from P. gingivalis (signaling through TLR2) was slightly superior to E. coli-derived LPS (TLR4 ligand) for inducing the high IL-23-secreting DC-like phenotype, but greatly inferior for inducing IL-12 p70 production when paired with IFN-γ, a distinction reflected in activated DCs’ ability to deviate lymphocytes toward Th1. Collectively, our data suggest TLR2 ligands encountered by innate immune cells in an environment with physiologically-relevant levels of extracellular ATP can induce a distinct activation state favoring IL-23- and IL-1β-dependent Th17 type response.

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“…The presence of cagA and cagE in H. pylori were isolated from Chinese, Indian, and Malay patients in Singapore ranged from 92.3 to 100% [ 3 ]. The H. pylori was found to be associated to many diseases including chronic gastritis, peptic ulcer disease, gastric mucosa associated lymphoid tissue lymphoma, and gastric adenocarcinoma [ 8 – 13 ]. Antibiotics are most commonly used clinically for the treatment of diseases associated with H. pylori .…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of bifidobacterium quadruple viable tablets in the treatment of Helicobacter pylori-infected peptic ulcer or gastritis patients: a systematic review and meta-analysis

Jiang

Liu

et al. 2023

BMC Infect Dis

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Background To better understand the efficacy and safety of Bifidobacterium quadruple viable tablets in the treatment of helicobacter pylori (H. pylori)-infected peptic ulcer or gastritis patients. Methods A systematic review of the studies published to June 2022 was performed in English database PubMed, Embase, Chinese database CNKI, Wanfang. There were 17 studies were included in this systematic review and meta-analysis. The outcomes measured included H. pylori eradication rate, changes in clinical symptoms of epigastric pain scores, and the incidence of adverse reactions. Results The results of the fixed effect model showed that the eradication rate of H. pylori in the combination of Bifidobacterium quadruple viable bacteria tablets combined with bismuth-containing conventional quadruple therapy was greater than that of bismuth-containing conventional quadruple therapy, and the difference was statistically significant (OR = 3.73, 95%CI (2.79,5.00), Z = 2.78, P < 0.001; I2 = 0.0%, P > 0.999). The results of random effects model showed that the epigastric pain score of Bifidobacterium quadruple viable bacteria tablets combined with bismuth-containing conventional quadruple therapy was lower than that of bismuth-containing conventional quadruple therapy, and the difference was statistically significant (WMD=-0.70, 95%CI (-1.06,-0.34), Z = 3.82, P < 0.001; I2 = 96.7%, P < 0.001). The results of random effects model showed that the acid reflux score of Bifidobacterium quadruple viable bacteria tablets combined with bismuth-containing conventional quadruple therapy was lower than that of bismuth-containing conventional quadruple therapy, and the difference was statistically significant (WMD=-0.98, 95%CI (-1.70,-0.26), Z = 2.66, P < 0.001; I2 = 99.7%, P < 0.001). Conclusions The eradication rate of H. pylori by Bifidobacterium quadruple viable bacteria tablets combined with bismuth-containing quadruple therapy is better than that of bismuth-containing quadruple therapy. The improvement of clinical symptoms of patients is better than that of bismuth-containing quadruple therapy, and the incidence of adverse reactions is lower than that of bismuth-containing quadruple therapy. Bifidobacterium quadruple viable bacteria tablet combined with bismuth-containing quadruple therapy was effective and safe. It provides a new way to treat patients with H. pylori.

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Helicobacter pylori infection appears the prime risk factor for stomach cancer

Cited by 8 publications

References 7 publications

Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis

Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis

Extracellular ATP and Toll-Like Receptor 2 Agonists Trigger in Human Monocytes an Activation Program That Favors T Helper 17

Efficacy and safety of bifidobacterium quadruple viable tablets in the treatment of Helicobacter pylori-infected peptic ulcer or gastritis patients: a systematic review and meta-analysis

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