<i>Helicobacter pylori</i> genotype and polymorphisms in DNA repair enzymes: Where do they correlate in gastric cancer?

Silva-Fernandes, Isabelle Joyce de Lima; Silva, Thayse Azevedo da; Agnez-Lima, Lucymara Fassarella; Ferreira, Márcia Valéria Pitombeira; Rabenhorst, Sílvia Helena Barem

doi:10.1002/jso.23077

Cited by 7 publications

(4 citation statements)

References 37 publications

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“…Our data show a higher frequency of the heterozygous genotype TG, followed by the wild-type TT and the homozygous variant GG. A similar distribution was observed in a study conducted in Poland [25], China [26], Turkey [27] and northeastern Brazil [28] in others cancers. The Asp148Glu polymorphism has been associated with an increased risk of colorectal [25], lung [29] and head and neck [30] cancers.…”

Section: Discussionsupporting

confidence: 86%

Effect of APE1 T2197G (Asp148Glu) Polymorphism on APE1, XRCC1, PARP1 and OGG1 Expression in Patients with Colorectal Cancer

Santos

Funck

Silva-Fernandes

et al. 2014

IJMS

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It has been hypothesized that genetic variation in base excision repair (BER) might modify colorectal adenoma risk. Thus, we evaluated the influence of APE1 T2197G (Asp148Glu) polymorphism on APE1, XRCC1, PARP1 and OGG1 expression in normal and tumor samples from patients with colorectal cancer. The results indicate a downregulation of OGG1 and an upregulation of XRCC1 expression in tumor tissue. Regarding the anatomical location of APE1, OGG1 and PARP-1, a decrease in gene expression was observed among patients with cancer in the rectum. In patients with or without some degree of tumor invasion, a significant downregulation in OGG1 was observed in tumor tissue. Interestingly, when taking into account the tumor stage, patients with more advanced grades (III and IV) showed a significant repression for APE1, OGG1 and PARP-1. XRCC1 expression levels were significantly enhanced in tumor samples and were correlated with all clinical and histopathological data. Concerning the polymorphism T2197G, GG genotype carriers exhibited a significantly reduced expression of genes of the BER repair system (APE1, XRCC1 and PARP1). In summary, our data show that patients with colorectal cancer present expression changes in several BER genes, suggesting a role for APE1, XRCC1, PARP1 and OGG1 and APE1 polymorphism in colorectal carcinogenesis.

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Section: Discussionsupporting

confidence: 86%

Effect of APE1 T2197G (Asp148Glu) Polymorphism on APE1, XRCC1, PARP1 and OGG1 Expression in Patients with Colorectal Cancer

Santos

Funck

Silva-Fernandes

et al. 2014

IJMS

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“…APE-1 expression is increased in gastric cancer and other malignancies and it is increased in gastric epithelial cells by H. pylori infection. These results suggest that it plays a role in carcinogenesis [30] and, interestingly, APE-1 is known to regulate oxidative stress, chemokine expression, and apoptosis [31].…”

Section: Regulation Of Host Response To Infectionmentioning

confidence: 92%

Helicobacter pylori in Gastric Malignancies

Bhandari

Crowe

2012

Curr Gastroenterol Rep

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Helicobacter pylori infection remains common worldwide and is significantly associated with gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue (MALT)lymphoma. This article reviews recent developments in the field of H. pylori with an emphasis on mechanisms of carcinogenesis, and the bacterial, environmental and host factors that may alter risk of developing gastric cancer or gastric MALT lymphoma. The topic of eradication of H. pylori to prevent the development of malignancy and the possibility of a vaccine against H. pylori are also explored.

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“…Zhang et al then showed that the CC genotype could increase the risk of GC jointly with CagA(+) H. pylori infection. Silva-Fernandes et al showed that rs1136410 in PARP1 was associated with the strains of H.pylori infected and that the C allele carriers had a higher proportion of highvirulence strains of H. pylori [67]. These studies suggest that the SNP could exert pressure on the bacteria and influence the outcome of the infection [67].…”

Section: Dna Repairmentioning

confidence: 99%

“…Silva-Fernandes et al showed that rs1136410 in PARP1 was associated with the strains of H.pylori infected and that the C allele carriers had a higher proportion of highvirulence strains of H. pylori [67]. These studies suggest that the SNP could exert pressure on the bacteria and influence the outcome of the infection [67]. However, Li et al studied the role of rs1136410 in the evolution of precancerous gastric lesions in a cohort of 1281 H. pylori-seropositive subjects and found no positive association.…”

Section: Dna Repairmentioning

confidence: 99%

Interaction Between Helicobacter Pylori and Host Genetic Variants in Gastric Carcinogenesis

et al. 2016

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Helicobacter pylori (H. pylori) is the definite carcinogen of gastric cancer. H. pylori infection induces chronic inflammation, causes DNA damage and aberrant methylation of genes and these pathways are involved in H. pylori-related gastric carcinogenesis. Polymorphisms of the genes involved in these pathways could alter susceptibility to gastric cancer. In this mini review, we focused on the role of polymorphisms in these genes on the susceptibility to gastric cancer, with a particular emphasis on their possible interactions with H. pylori infection. We found that many studies on this theme did not simultaneously report H. pylori infection and the interactions remained inconclusive.

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Helicobacter pylori genotype and polymorphisms in DNA repair enzymes: Where do they correlate in gastric cancer?

Cited by 7 publications

References 37 publications

Effect of APE1 T2197G (Asp148Glu) Polymorphism on APE1, XRCC1, PARP1 and OGG1 Expression in Patients with Colorectal Cancer

Effect of APE1 T2197G (Asp148Glu) Polymorphism on APE1, XRCC1, PARP1 and OGG1 Expression in Patients with Colorectal Cancer

Helicobacter pylori in Gastric Malignancies

Interaction Between Helicobacter Pylori and Host Genetic Variants in Gastric Carcinogenesis

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