<i>Helicobacter pylori</i> eradication in long‐term proton pump inhibitor users is highly cost‐effective: economic analysis of the HELPUP trial

Mason, James; Raghunath, A. S.; Hungin, A. P. S.; Jackson, Warren

doi:10.1111/j.1365-2036.2008.03851.x

Cited by 10 publications

(4 citation statements)

References 14 publications

(19 reference statements)

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“…Decision making on a case‐by‐case basis was recommended. The cost‐effectiveness of treating H. pylori in long‐term PPI users in primary care has recently been shown with the benefit related to reduced symptom severity and a reduction in PPI use and other health‐care costs 31 …”

Section: Consensus Statementsmentioning

confidence: 99%

Second Asia–Pacific Consensus Guidelines for Helicobacter pylori infection

Fock

Katelaris

Sugano

et al. 2009

J of Gastro and Hepatol

509

427

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The Asia-Pacific Consensus Conference was convened to review and synthesize the most current information on Helicobacter pylori management so as to update the previously published regional guidelines. The group recognized that in addition to long-established indications, such as peptic ulcer disease, early mucosa-associated lymphoid tissue (MALT) type lymphoma and family history of gastric cancer, H. pylori eradication was also indicated for H. pylori infected patients with functional dyspepsia, in those receiving long-term maintenance proton pump inhibitor (PPI) for gastroesophageal reflux disease, and in cases of unexplained iron deficiency anemia or idiopathic thrombocytopenic purpura. In addition, a population 'test and treat'strategy for H. pylori infection in communities with high incidence of gastric cancer was considered to be an effective strategy for gastric cancer prevention. It was recommended that H. pylori infection should be tested for and eradicated prior to long-term aspirin or non-steroidal anti-inflammatory drug therapy in patients at high risk for ulcers and ulcer-related complications. In Asia, the currently recommended first-line therapy for H. pylori infection is PPI-based triple therapy with amoxicillin/metronidazole and clarithromycin for 7 days, while bismuth-based quadruple therapy is an effective alternative. There appears to be an increasing rate of resistance to clarithromycin and metronidazole in parts of Asia, leading to reduced efficacy of PPI-based triple therapy. There are insufficient data to recommend sequential therapy as an alternative first-line therapy in Asia. Salvage therapies that can be used include: (i) standard triple therapy that has not been previously used; (ii) bismuth-based quadruple therapy; (iii) levofloxacin-based triple therapy; and (iv) rifabutin-based triple therapy. Both CYP2C19 genetic polymorphisms and cigarette smoking can influence future H. pylori eradication rates. Key wordshelicobacter pylori:diagnosis, helicobacter pylori:treatment and antimicrobial resistance, H. pylori and gastric cancer.

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Section: Consensus Statementsmentioning

confidence: 99%

Second Asia–Pacific Consensus Guidelines for Helicobacter pylori infection

Fock

Katelaris

Sugano

et al. 2009

J of Gastro and Hepatol

509

427

View full text Add to dashboard Cite

show abstract

“…Another study examined the cost‐effectiveness of H. pylori treatment in H. pylori ‐positive long‐term proton pump inhibitor (PPI) users in the UK randomly assigned to anti‐ H. pylori therapy ( n = 93) or placebo ( n = 91) [50]. After 2 years, the treatment group had substantially fewer prescriptions, GP consultations and GI‐related home visits, upper endoscopies, abdomen/pelvis ultrasound scans, and dyspepsia symptoms, although heartburn symptoms increased.…”

Section: Public Health Policymentioning

confidence: 99%

The Epidemiology of Helicobacter pylori and Public Health Implications

2009

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This article presents a review of the literature on the epidemiology and public health implications of Helicobacter pylori infection published from April 2008 through to March 2009. The authors used MeSH terms “Helicobacter infections epidemiology,”“Helicobacter infections prevention and control” to search multiple databases (PubMed, Embase, Cochrane, Cochrane Library, EBMR, BIOSIS), and independently searched PubMed using the term “Helicobacter” with “Epidemiology,”“Transmission,”“Prevalence” or “Environment.” Articles without topical relevance were excluded. Two additional papers known to the authors were added. The identified literature is summarized by subtopic: reviews; prevalence; incidence; transmission; risk factors; and public health policy.

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“…No evidence of neoplastic changes was found. H. pylori eradication in infected long-term PPI users is an economically dominant strategy, significantly reducing symptom severity and overall healthcare costs [35].…”

Section: Recommendation Grade: A; Evidence Level: 1c; Agreement Levelmentioning

confidence: 99%

Hellenic consensus on Helicobacter pylori infection

Georgopoulos

Michopoulos

Rokkas³

et al. 2020

aog

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The Hellenic Society of Gastroenterology recently organized the "Hellenic consensus on Helicobacter pylori (H. pylori) infection". The aim of this publication is to report the guidelines in order to aid the national gastroenterology community in the management of H. pylori infection. Forty-one delegates from all Greek regions, including gastroenterologists, pathologists, clinical microbiologists, epidemiologists and basic scientists, were invited to this meeting. The participants were allocated to 1 of the 4 main topics of the meeting: i.e., H. pylori diagnosis and association with diseases; H. pylori and gastric cancer; H. pylori and extragastric associated disorders; and H. pylori treatment. The results of each subgroup were submitted to a final consensus vote that included all participants. Relevant data based on international and Greek publications were presented, and the quality of evidence, strength of recommendation, and level of consensus were graded. The cutoff level of 70% was considered as acceptance for the final statement. It is hoped that the recommendations and conclusions of this report will guide Greek doctors in their daily practice concerning the management of H. pylori infection.

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Helicobacter pylori eradication in long‐term proton pump inhibitor users is highly cost‐effective: economic analysis of the HELPUP trial

Abstract: SUMMARY BackgroundProton pump inhibitor (PPI) use is costly and about two-thirds of prescribing is long-term. Although 20-50% of patients may be infected with Helicobacter pylori, eradication is not normal clinical practice.

Cited by 10 publications

References 14 publications

Second Asia–Pacific Consensus Guidelines for Helicobacter pylori infection

Second Asia–Pacific Consensus Guidelines for Helicobacter pylori infection

The Epidemiology of Helicobacter pylori and Public Health Implications

Hellenic consensus on Helicobacter pylori infection

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