Helicobacter pylori eradication decreases blood neutrophil and monocyte counts

Kondo, Yuto; T, Joh; Sasaki, Makoto; Oshima, Tadayuki; Itoh, Kazuko; Tanida, Satoshi; Kataoka, Hiromi; Ohara, Hirotaka; Nomura, Tomoyuki; Itoh, Makoto

doi:10.1111/j.1365-2036.2004.01988.x

Cited by 13 publications

(13 citation statements)

References 29 publications

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“…White blood cell, neutrophil, and lymphocyte counts have been reported to increase in H. pylori-infected patients [20,21]. In the present study, these counts were slightly higher in H. pylori-infected patients than in control subjects, and they decreased after eradication of H. pylori.…”

Section: Discussioncontrasting

confidence: 43%

Regulatory T cells percentage in peripheral blood before and after eradication of Helicobacter pylori

Satoh¹,

Ogawara²,

Kawamura³

et al. 2014

Health

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Helicobacter pylori (H. pylori) induces gastroduodenal diseases and vigorous humural and cellular immune abnormalities. In order to clarify the immunological changes before and after eradication of H. pylori, the percentages and ratios of the following cells in the peripheral blood of 32 H. pylori-infected patients and 25 control subjects were analyzed: CD4+ T cells, CD8+ T cells, T helper 1 cells (Th1), T helper 2 cells (Th2), CD4+CD25+ T cells, Foxp3+ regulatory T cells (Treg), CD4/CD8 ratio, and Th1/Th2 ratio. CD4/CD8 ratio was significantly higher in H. pylori-infected patients before (mean ± SD, 2.9 ± 1.9) and after (mean ± SD, 2.8 ± 1.6) eradication of H. pylori than in control subjects (mean ± SD, 2.1 ± 0.9). The percentage of Th2 cells was significantly higher in H. pylori-infected patients (mean ± SD, 2.6 ± 1.1) than in control subjects (mean ± SD, 1.9 ± 1.1; p < 0.02). The percentage of Th2 cells after eradication of H. pylori (mean ± SD, 2.3 ± 1.4) was lower than that before eradication. There was no significant difference between control subjects (mean ± SD, 4.1% ± 1.5%) and patients before H. pylori eradication (mean ± SD, 4.5% ± 2.4%) in the percentage of Tregs, but the percentage was significantly higher in patients after H. pylori eradication (mean ± SD, 5.2% ±2.6%) than in control subjects. The function of peripheral induced Tregs was reported to sup-press the excessive immune reaction in chronic inflammation. These data suggest that Tregs may proliferate and be activated to suppress the activation of humoral immunity in H. pylori-infected patients, and these changes continue after 3 months or later of successful eradication of H. pylori.

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Section: Discussioncontrasting

confidence: 43%

Regulatory T cells percentage in peripheral blood before and after eradication of Helicobacter pylori

Satoh¹,

Ogawara²,

Kawamura³

et al. 2014

Health

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“…Kondo et al have analyzed peripheral blood mononuclear cell counts; specifically neutrophil and monocyte counts, in the peripheral blood of Hp (+) patients. They observed an increase in neutrophil and monocyte counts and therefore concluded that H. pylori infection plays a role in systemic disorders (23). Besides that, Karttunen et al observed a significant increase in peripheral blood basophiles in H. pylori patients (24).…”

Section: Discussionmentioning

confidence: 99%

Analysis of peripheral blood lymphocyte phenotypes and Th1/Th2 cytokines profile in the systemic immune responses of Helicobacter pylori infected individuals

Kayhan¹,

Araslı²,

Eren³

et al. 2008

Microbiology and Immunology

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H. pylori elicits specific humoral and cellular immune responses in the mucosal immune system. However, the type and extent of T lymphocyte response in the systemic immune system is not clear for H. pylori positive patients. In this study, peripheral blood T lymphocyte phenotypes and serum Th1/Th2 based cytokines of 32 H. pylori positive patients were analyzed and compared to those of healthy controls. While αβ TCR + lymphocytes and their phenotype analysis were not significantly different to those of healthy controls, the percentage of pan γδ TCR + lymphocytes was up to 2.4 times greater in the H. pylori positive group then in healthy controls. Furthermore, significant increases in IL-10 concentrations in serum samples of H. pylori patients indicated that their immune systems had switched toward a Th2 type immune response. The correlation between phenotype and type of T cell response in the peripheral blood during H. pylori infection is discussed.

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“…Also, it was found in the eradicated group that neutrophils and monocytes counts were decreased significantly after eradication, with no significant change in eosinophils, basophils, and lymphocytes. On the other hand, there was no significant change in leucocytes in the noneradicated group 46 . These results were against the present study and may be due to different strains of the bacterium involved.…”

Section: Discussionmentioning

confidence: 70%

Prevalence of Helicobacter Pylori Infection in Anemic and Non-Anemic Children in Helwan, Egypt : Impact on Blood Cell Parameters

Elnemr

2016

Egyptian Journal of Hospital Medicine

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Background: Helicobacter (H.) pylori is the most common chronic bacterial infection of humans; affecting ~50% of the world's population. It is the cause of disease states of varying degrees of severity. Anemia is a widespread public health problem; ~50% of cases are diagnosed as iron deficiency anemia (IDA). Recent studies have suggested an association between H. pylori infection and IDA in children. Aims of the work: this study was conducted to evaluate the prevalence of H. pylori infection in children with and without IDA diagnosis and also to determine effects of the bacterium on complete blood count parameters of those children. Subjects and Methods: a case-control (retrospective) study design was chosen to conduct this research. The prevalence of H. pylori antibody (Ab) seropositivity was compared between 50 children diagnosed with IDA vs. 50 non-anemic control children matching in age and sex. Results: a total of 18 (36%) anemic and 10 (20%) non-anemic children were found positive to H. pylori Ab (P=0.0013). Also, comparison of the anemic to the control group revealed statistically significant lowering of ferritin, and red blood cell (RBC) parameters (i.e., hemoglobin, packed cell volume, mean corpuscular volume, and mean corpuscular hemoglobin), and also platelet count in the anemic group. Moreover, comparison of H. pylori positive and negative anemic children revealed statistically significant lowering of RBC parameters in the H. pylori positive anemic children. Also, comparison of H. pylori positive and negative children revealed statistically significant lowering of RBC parameters in H. pylori positive children. In addition, correlation of H. pylori with all other parameters revealed negative significant correlation between H. pylori and RBC parameters. Conclusions: H. pylori infection had a higher prevalence among preschool children with IDA and the hematological impact was more on H. pylori positive anemic children. Recommendations: both IDA and H. pylori are treatable diseases, so children having IDA must be investigated for H. pylori infection for early treatment to avoid serious complications of both diseases.

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Helicobacter pylori eradication decreases blood neutrophil and monocyte counts

Cited by 13 publications

References 29 publications

Regulatory T cells percentage in peripheral blood before and after eradication of <i>Helicobacter pylori</i>

Regulatory T cells percentage in peripheral blood before and after eradication of <i>Helicobacter pylori</i>

Analysis of peripheral blood lymphocyte phenotypes and Th1/Th2 cytokines profile in the systemic immune responses of Helicobacter pylori infected individuals

Prevalence of Helicobacter Pylori Infection in Anemic and Non-Anemic Children in Helwan, Egypt : Impact on Blood Cell Parameters

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Helicobacter pylori eradication decreases blood neutrophil and monocyte counts

Cited by 13 publications

References 29 publications

Regulatory T cells percentage in peripheral blood before and after eradication of &lt;i&gt;Helicobacter pylori&lt;/i&gt;

Regulatory T cells percentage in peripheral blood before and after eradication of &lt;i&gt;Helicobacter pylori&lt;/i&gt;

Analysis of peripheral blood lymphocyte phenotypes and Th1/Th2 cytokines profile in the systemic immune responses of Helicobacter pylori infected individuals

Prevalence of Helicobacter Pylori Infection in Anemic and Non-Anemic Children in Helwan, Egypt : Impact on Blood Cell Parameters

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Product

Resources

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Regulatory T cells percentage in peripheral blood before and after eradication of <i>Helicobacter pylori</i>

Regulatory T cells percentage in peripheral blood before and after eradication of <i>Helicobacter pylori</i>