<i>Helicobacter pylori</i> and the t(11;18)(q21;q21) Translocation in Gastric Low‐grade B‐Cell Lymphoma of Mucosa‐associated Lymphoid Tissue Type

Nakamura, Toshiyasu; Nakamura, Shigeo; Yonezumi, Masakatsu; Suzuki, Takashi; Matsuura, Akihiro; Yatabe, Yasushi; Yokoi, Takeshi; Ohashi, Kazuhiko; Seto, Masao

doi:10.1111/j.1349-7006.2000.tb00945.x

Cited by 60 publications

(62 citation statements)

References 21 publications

(40 reference statements)

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“…As we and others recently reported, API2-MALT1 gene fusion may confer inflammation-independent growth to gastric MALT lymphomas and hence resistance to H. pylori eradication therapy. [45][46][47] The alternative explanation for lack of API2-MALT1 gene fusion in thymic MALT lymphoma is that it is an early lymphoma in the evolution chain. 48 However, this does not seem likely because most of the thymic MALT lymphomas already form bulky masses at diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Primary Thymic Extranodal Marginal-Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Type Exhibits Distinctive Clinicopathological and Molecular Features

Inagaki

Chan

et al. 2002

The American Journal of Pathology

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101

106

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Extranodal marginal-zone B-cell lymphoma (MZBL) of mucosa-associated lymphoid tissue (MALT) arising in the thymus is rare, with the largest series in the literature including only three cases. In the present study, we investigated 15 cases of thymic MALT lymphoma to systematically characterize its clinical, histopathological, and molecular features. There was a marked female predilection (male:female ‫؍‬ 1:4), with a mean age of 55 years at diagnosis. There was a strong association with autoimmune disease, especially Sjögren's syndrome.

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Section: Discussionmentioning

confidence: 99%

Primary Thymic Extranodal Marginal-Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Type Exhibits Distinctive Clinicopathological and Molecular Features

Inagaki

Chan

et al. 2002

The American Journal of Pathology

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101

106

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“…9,11,12 The API2-MALT1 chimeric transcript mediated by t(11; 18) (q21; q21) translocation is one of the characteristic genetic alterations observed in a certain proportion of low-grade MALT lymphomas. 13,26,33 It has been clarified that most patients with gastric MALT lymphoma with this translocation do not respond to H. pylori eradication therapy. 13,26,33 In the current study, 3 patients positive for the API2-MALT1 chimeric transcript showed NR after eradication therapy.…”

Section: Discussionmentioning

confidence: 99%

“…13,26,33 It has been clarified that most patients with gastric MALT lymphoma with this translocation do not respond to H. pylori eradication therapy. 13,26,33 In the current study, 3 patients positive for the API2-MALT1 chimeric transcript showed NR after eradication therapy. However, the chimeric transcript was not a significant predictive factor for a response to eradication therapy, probably due to its low prevalence in our series (6%) ( Table 1).…”

Section: Discussionmentioning

confidence: 99%

Long‐term clinical outcome of Helicobacter pylori eradication for gastric mucosa‐associated lymphoid tissue lymphoma with a reference to second‐line treatment

Nakamura

Matsumoto

Suekane

et al. 2005

Cancer

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BACKGROUNDThe goals of the current study were to elucidate the long‐term outcome of Helicobacter pylori eradication therapy for gastric mucosa‐associated lymphoid tissue (MALT) lymphoma and to clarify the therapeutic efficacy of stomach‐conserving treatments for patients not responding to eradication therapy.METHODSNinety‐six patients with gastric MALT lymphoma, including 17 patients with areas of diffuse large B‐cell lymphoma, were treated by H. pylori eradication. Patients not responding to eradication therapy underwent either a gastrectomy, multiagent chemotherapy, oral monochemotherapy (OMC), or radiotherapy (RT). Predictive factors for the response to eradication therapy, overall survival (OS), and event‐free survival (EFS) were determined by the Kaplan–Meier analysis with the log‐rank test. The efficacy of second‐line treatment was compared between OMC and RT.RESULTSAfter eradication therapy, 62 (65%) patients achieved complete disease remission (CR). Transient histologic disease recurrence was confirmed in 4 (6.5%) of 62 patients with CR during the follow‐up (median, 37.5 months). The OS and EFS probabilities after 5 years were 0.96 and 0.80, respectively. Second‐line treatment was performed in 31 patients; gastrectomy in 4 patients, multiagent chemotherapy in 5 patients, OMC in 12 patients, and RT in 10 patients. There were no differences in the CR rate, OS, EFS, or toxicity between the OMC and RT groups.CONCLUSIONSH. pylori eradication therapy was an effective first‐line treatment for patients with gastric MALT lymphoma, which led to a favorable long‐term outcome. OMC and RT had an equivalent efficacy as a second‐line treatment in nonresponding patients to eradication therapy. Cancer 2005. © 2005 American Cancer Society.

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“…All the breakpoints in the API2 gene occur between the third BIR domain and the C-terminal RING, with 91% occurring just upstream of the CARD. [38][39][40][41] In contrast, the breakpoints in the MALT1 gene are more variable. [38][39][40][41] Thus, the resultant API2-MALT1 fusion transcripts always comprise a truncated API2 with 3 intact BIR domains but without the C-terminal RING or without both the middle CARD and C-terminal RING in most.…”

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confidence: 99%

“…24,37 By reverse transcription-polymerase chain reaction (RT-PCR) of the API2-MALT1 fusion transcript, Southern blot analysis, and interphase fluorescence in situ hybridization for t(11;18)(q21;q21), the translocation has been found in 30% to 50% MALT lymphoma of various sites but not in nodal or splenic marginal zone B-cell lymphoma. [38][39][40][41][42] However, it remains to be determined how this translocation contributes to the progression of MALT lymphoma.Interestingly, there appears to be no difference in histology, immunophenotype, and clinical behavior between MALT lymphomas with t(1;14)(p22;q32) and t(11;18)(q21;q21). It is thus possible that both translocations exert their oncogenic activities through a similar pathway.…”

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confidence: 99%

T(11;18)(q21;q21) is associated with advanced mucosa-associated lymphoid tissue lymphoma that expresses nuclear BCL10

Liu

Doğan

et al. 2001

Blood

228

196

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The development of gastric mucosaassociated lymphoid tissue (MALT) lymphoma is a multistep process and can be clinico-pathologically divided into Helicobacter pylori-associated gastritis, lowgrade tumors, and high-grade tumors. The molecular events underlying this progression are largely unknown. However, identification of the genes involved in MALT lymphoma-specific t(11;18)(q21; q21) and t(1;14)(p22;q32) has provided fresh insights into the pathogenesis of this disease. T(11;18)(q21;q21) results in a chimeric transcript between the API2 and the MALT1 genes, whereas t(1;14) (p22;q32) causes aberrant nuclear BCL10 expression. Significantly, nuclear BCL10 expression also occurs frequently in MALT lymphomas without t(1;14)(p22; q32), suggesting an important role for BCL10 in lymphoma development. Thirtythree cases of H pylori gastritis, 72 MALT lymphomas, and 11 mucosal diffuse large B-cell lymphomas (DLBCL) were screened for t(11;18)(q21;q21) by reverse transcription-polymerase chain reaction followed by sequencing. BCL10 expression in lymphoma cases was examined by immunohistochemistry. The API2-MALT1 fusion transcript was not detected in H pylori gastritis and mucosal DLBCL but was found in 25 of 72 (35%) MALT lymphomas of various sites. Nuclear BCL10 expression was seen in 28 of 53 (53%) of MALT lymphomas. Of the gastric cases, the largest group studied, the frequency of both t(11;18)(q21;q21) and nuclear BCL10 expression was significantly higher in tumors that showed dissemination to local lymph nodes or distal sites (14 of 18 ‫؍‬ 78% and 14 of 15 ‫؍‬ 93%, respectively) than those confined to the stomach (3 of 29 ‫؍‬ 10% and 10 of 26 ‫؍‬ 38%). Furthermore, t(11;18)(q21;q21) closely correlated with BCL10 nuclear expression. These results indicate that both t(11;18)(q21;q21) and BCL10 nuclear expression are associated with advanced MALT lymphoma and that their oncogenic activities may be related to each other. IntroductionThe development of mucosa-associated lymphoid tissue (MALT) lymphoma is a multistage process. 1 This is best understood in gastric MALT lymphoma, the most common form. Typically, low-grade gastric MALT lymphoma arises from mucosal lymphoid tissue that is acquired usually as a reaction to Helicobacter pylori infection. 2,3 Low-grade MALT lymphoma is initially confined to the gastric mucosa, and its growth depends critically on the contact help of H pylori-specific intratumoral T cells; therefore, it responds favorably to H pylori eradication therapy. [4][5][6] However, when the lymphoma invades the deep layers of the gastric wall and disseminates to local lymph nodes and distal sites, the tumor loses its dependence on H pylori-specific T cells and is no longer sensitive to H pylori eradication therapy. 7-9 Finally, low-grade gastric MALT lymphoma may transform into a more aggressive diffuse large B-cell lymphoma (DLBCL). 10,11 Direct 12-14 and indirect antigen stimulation 4,5 and several genetic factors, including genetic instability, 15 trisomy 3, 16 p53 mutation/LOH, 17 p16 deletion, 18 t(1;...

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Helicobacter pylori and the t(11;18)(q21;q21) Translocation in Gastric Low‐grade B‐Cell Lymphoma of Mucosa‐associated Lymphoid Tissue Type

Cited by 60 publications

References 21 publications

Primary Thymic Extranodal Marginal-Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Type Exhibits Distinctive Clinicopathological and Molecular Features

Primary Thymic Extranodal Marginal-Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Type Exhibits Distinctive Clinicopathological and Molecular Features

Long‐term clinical outcome of Helicobacter pylori eradication for gastric mucosa‐associated lymphoid tissue lymphoma with a reference to second‐line treatment

T(11;18)(q21;q21) is associated with advanced mucosa-associated lymphoid tissue lymphoma that expresses nuclear BCL10

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