<i>Helicobacter pylori</i> and the intestinal microbiome among healthy school‐age children

Lapidot, Yelena; Cohen, Dani; Muhsen, Khitam

doi:10.1111/hel.12854

Cited by 16 publications

(18 citation statements)

References 71 publications

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“…In addition, the microbiota in the gastrointestinal tract can also affect the colonization of H. pylori , and studies have found that Lactobacillus can inhibit the growth of H. pylori strains and can be used in the treatment of H. pylori infections ( Salas-Jara et al, 2016 ; Huang et al, 2022 ). Studies have shown a significant correlation between H. pylori infection and the composition of the gastrointestinal microbiota, particularly Prevotella copri and Eubacterium biforme ( Lapidot et al, 2021 ).…”

Section: H Pylori Gastrointestinal Microbiota and Fdmentioning

confidence: 99%

The Role of Gastrointestinal Microbiota in Functional Dyspepsia: A Review

Zhou¹,

Zeng

Zhang

et al. 2022

Front. Physiol.

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Functional dyspepsia is a clinically common functional gastrointestinal disorder with a high prevalence, high impact and high consumption of medical resources. The microbiota in the gastrointestinal tract is a large number of families and is one of the most complex microbial reservoirs in the human body. An increasing number of studies have confirmed the close association between dysbiosis of the gastrointestinal microbiota and the occurrence and progression of functional dyspepsia. Therefore, we reviewed the role of dysbiosis of the gastrointestinal microbiota, H. pylori infection and gastrointestinal microbiota metabolites in functional dyspepsia, focusing on the possible mechanisms by which dysbiosis of the gastrointestinal microbiota contributes to the pathogenesis of functional dyspepsia. Several studies have confirmed that dysbiosis of the gastrointestinal microbiota may cause the occurrence and progression of functional dyspepsia by disrupting the biological barrier of the intestinal mucosa, by disturbing the immune function of the intestinal mucosa, or by causing dysregulation of the microbial-gut-brain axis. Probiotics and antibiotics have also been chosen to treat functional dyspepsia in clinical studies and have shown some improvement in the clinical symptoms. However, more studies are needed to explore and confirm the relationship between dysbiosis of the gastrointestinal microbiota and the occurrence and progression of functional dyspepsia, and more clinical studies are needed to confirm the therapeutic efficacy of microbiota modulation for functional dyspepsia.

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Section: H Pylori Gastrointestinal Microbiota and Fdmentioning

confidence: 99%

The Role of Gastrointestinal Microbiota in Functional Dyspepsia: A Review

Zhou¹,

Zeng

Zhang

et al. 2022

Front. Physiol.

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“…Recently, H. pylori was reported to be closely associated with abdominal pain in children, and histological examination clearly revealed that H. pylori is located in the gastric mucosa. 29 Helicobacter pylori can transmit from human to human, that is, H. pylori in children might be from their parents. 30 Long-term infection with H. pylori affects the growth and development of children.…”

Section: Discussionmentioning

confidence: 99%

“…Helicobacter pylori is considered a simple commensal organism in gastritis patients, including adults and children. Recently, H. pylori was reported to be closely associated with abdominal pain in children, and histological examination clearly revealed that H. pylori is located in the gastric mucosa 29 . Helicobacter pylori can transmit from human to human, that is, H. pylori in children might be from their parents 30 .…”

Section: Discussionmentioning

confidence: 99%

SHP2/SPI1axis promotes glycolysis and the inflammatory response of macrophages in Helicobacter pylori‐induced pediatric gastritis

Gong

et al. 2022

Helicobacter

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Background Macrophages, as innate immune cells, were reported to participate in the pathogenesis of Helicobacter pylori (H. pylori)‐induced gastritis. However, the role and mechanism of macrophage dysfunction in H. pylori‐associated pediatric gastritis remain unclear. Materials and Methods An RNA‐sequencing assay was used to examine the differential gene expression in normal gastric antrum, non‐H. pylori‐infected tissue, and H. pylori‐infected pediatric gastritis tissue. qPCR assays were applied to verify the expression of target genes. HE staining was performed to identify the occurrence of inflammation in the normal gastric antrum, non‐H. pylori‐infected tissue, and H. pylori‐infected pediatric gastritis tissue. Western blotting was used to measure the expression of SHP2 in pediatric gastritis tissue. The metabolic profile of macrophages was determined via Seahorse metabolic analysis. Flow cytometry analysis was used to examine the level of reactive oxygen species (ROS). Results We found that H. pylori ‐infected gastritis tissue exhibited many differentially expressed genes (DEGs) compared to gastritis tissue without H. pylori infection. Moreover, H. pylori ‐infected gastritis tissue showed many DEGs annotated with an overactive immune response. We identified that tyrosine‐protein phosphatase nonreceptor type 11 (PTPN11), which encodes SHP2, was significantly increased in macrophages of H. pylori ‐infected gastritis tissue. Furthermore, we revealed that SHP2 could activate the glycolytic function of macrophages to promote H. pylori ‐induced inflammation. The transcription factor SPI1 , as the downstream molecule of SHP2, could be responsible for the regulation of metabolism‐associated gene expression and inflammation. Conclusion Our study illustrated the molecular landscape of H. pylori‐infected gastritis tissue in children and suggested that the SHP2/SPI1axis could be a novel therapeutic target in H. pylori‐induced pediatric gastritis.

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“…H. pylori infection affects the microbiome of the stomach and gut ( 48 , 49 ). A recent study showed a significant effect of enteric infections on the immune response to OPV in children from India, while the gut microbiome did not have any impact in this population ( 50 ).…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Helicobacter pylori IgG Seroprevalence and the Immune Response to Poliovirus Vaccine Among School-Age Children From a Population With Near-Universal Immunity Level

Zher

Weil²,

Kassem³

et al. 2022

Front. Med.

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ObjectivesTo examine the association between Helicobacter pylori seroprevalence and serum pepsinogens (PGs) as markers of gastric inflammation), with high neutralizing antibody titers to poliovirus type 1 and 3 vaccine strains among children age 3–4 years, subsequent to sub-clinical infection acquired during a wild-type poliovirus type 1 outbreak in Israel.MethodsA serosurvey was conducted among 336 children aged 5–17 years who were vaccinated with both inactivated polio vaccine and oral polio vaccines. H. pylori serum IgG antibodies and PG concentrations were measured using ELISA. Neutralizing antibodies to poliovirus vaccine strains were measured and children with a titer ≥1:8 were considered immune. High-level immunity was defined as having a serum NA titer >1:2048. Propensity score inverse weighting was used to account for confounders.ResultsNeutralizing antibodies titers ≥1:8 to poliovirus type 1 and 3 vaccine strains were found in 99.4 and 98.2% of the children, respectively. An inverse association was found between H. pylori seropositivity accompanied by PGI:PGII ratio ≤6.5 (marker of gastric inflammation) and high-level immunity to poliovirus type 1: OR 0.39 (95% CI 0.68–0.91), p = 0.027. The association between H. pylori seropositivity of CagA virulent phenotype and polio high immunity was not significant. The association between H. pylori seropositivity and high neutralizing antibodies to type 3 poliovirus was of low magnitude and not significant.ConclusionsH. pylori seroprevalence accompanied by evidence of gastric inflammation was inversely correlated with high titers of neutralizing antibodies to poliovirus in children from a population with near universal polio immunity.

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Helicobacter pylori and the intestinal microbiome among healthy school‐age children

Cited by 16 publications

References 71 publications

The Role of Gastrointestinal Microbiota in Functional Dyspepsia: A Review

The Role of Gastrointestinal Microbiota in Functional Dyspepsia: A Review

SHP2/SPI1axis promotes glycolysis and the inflammatory response of macrophages in Helicobacter pylori‐induced pediatric gastritis

Relationship Between Helicobacter pylori IgG Seroprevalence and the Immune Response to Poliovirus Vaccine Among School-Age Children From a Population With Near-Universal Immunity Level

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