<i>Helicobacter pylori</i> and Nonmalignant Diseases

Potamitis, Georgios S.; Axon, Anthony

doi:10.1111/hel.12253

Cited by 19 publications

(23 citation statements)

References 41 publications

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“…The discrepancy in the severity of gastric cancer is associated with many factors and mechanisms, among which various genotypes of H. pylori strains play a role [30][31][32][33][34][35][36][37][38][39][40]. H. pylori induces other diseases of the alimentary tract, including gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma, GERD symptoms, and dyspepsia [41][42][43][44][45][46]. There is an increasing interest in the role of H. pylori in the pathogenesis of ischemic heart disease, diabetes mellitus, and Alzheimer's disease [47][48][49][50].…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of the Epithelial–Mesenchymal Transition and Tumor Microenvironment in Helicobacter pylori-Induced Gastric Cancer

Baj

Korona-Głowniak

Forma

et al. 2020

Cells

112

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Helicobacter pylori (H. pylori) is one of the most common human pathogens, affecting half of the world's population. Approximately 20% of the infected patients develop gastric ulcers or neoplastic changes in the gastric stroma. An infection also leads to the progression of epithelial-mesenchymal transition within gastric tissue, increasing the probability of gastric cancer development. This paper aims to review the role of H. pylori and its virulence factors in epithelial-mesenchymal transition associated with malignant transformation within the gastric stroma. The reviewed factors included: CagA (cytotoxin-associated gene A) along with induction of cancer stem-cell properties and interaction with YAP (Yes-associated protein pathway), tumor necrosis factor α-inducing protein, Lpp20 lipoprotein, Afadin protein, penicillin-binding protein 1A, microRNA-29a-3p, programmed cell death protein 4, lysosomal-associated protein transmembrane 4β, cancer-associated fibroblasts, heparin-binding epidermal growth factor (HB-EGF), matrix metalloproteinase-7 (MMP-7), and cancer stem cells (CSCs). The review summarizes the most recent findings, providing insight into potential molecular targets and new treatment strategies for gastric cancer.

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Section: Introductionmentioning

confidence: 99%

Mechanisms of the Epithelial–Mesenchymal Transition and Tumor Microenvironment in Helicobacter pylori-Induced Gastric Cancer

Baj

Korona-Głowniak

Forma

et al. 2020

Cells

112

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“…H. pylori has been recognized as a causative agent of chronic gastritis [10,11]. However, extra-digestive effects on growth parameters have been reported in young children.…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori among symptomatic Egyptian children: prevalence, risk factors, and effect on growth

Galal

Ghobrial

Labib

et al. 2019

J. Egypt. Public. Health. Assoc.

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Aim: This study was carried out to determine the prevalence and predictors of Helicobacter pylori (H. pylori) infection among symptomatic children and the effect on growth. Methods: A cross-sectional study was conducted in the Outpatient Clinics of the Gastroenterology Unit of the Pediatric Hospital, Cairo University. A total of 630 children complaining of any symptoms or signs suspicious of H. pylori infection were enrolled. Weight and height were measured for each child, and the standard deviation scores (Z-scores) for weightfor-age (WAZ), weight-for-height (WHZ), and height-forage (HAZ) were calculated. H. pylori was diagnosed using a stool antigen test. Results: The overall prevalence of infection was 64.6%. Socio-demographic variables significantly associated with H. pylori were residence in Upper Egypt (P = 0.013) and rural areas (P = 0.004), illiteracy of mothers (P = 0.017), household crowding index ≥ 3 (P = 0.011), absence of pure water supply (P = 0.005), and eating from street vendors (P < 0.001). Values of WAZ [median, interquartile range (IQR) in infected = − 1.3(− 2.7 to − 0.4) and non-infected = − 0.7(− 2.1 to − 0.1), P < 0.001], HAZ (P = 0.036), and WHZ (P = 0.005) were significantly lower in children infected with H. pylori. After performing a backward logistic regression analysis, eating from street vendors (OR = 1.879, 95% CI 1.346-2.625, P < 0.001), absence of pure water supply (OR = 1.725, 95% CI 1.162-2.561, P = 0.007), and overcrowding (OR = 1.547, 95% CI 1.100-2.177, P = 0.012) remained the significant predictors of H. pylori infection. Conclusion: A high prevalence of H. pylori infection among symptomatic children was detected. The extra-digestive effects of H. pylori were revealed in the form of affection of growth parameters and reduced levels of serum hemoglobin, iron, and ferritin.

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“…There is now good evidence that infection with Helicobacter pylori is the principal cause of acute and chronic gastritis and atrophic gastritis. [1][2][3] More recently, however, there has been interest in the effects of H. pylori in extra-gastroduodenal diseases. [4][5][6][7] This interest has led researchers to investigate the effects of H. pylori in a wide range of growth outcomes.…”

Section: Introductionmentioning

confidence: 99%

Effect of Helicobacter pylori infection on growth trajectories in young Ethiopian children: a longitudinal study

Taye

Enquselassie

Tsegaye

et al. 2016

International Journal of Infectious Diseases

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Helicobacter pylori and Nonmalignant Diseases

Cited by 19 publications

References 41 publications

Mechanisms of the Epithelial–Mesenchymal Transition and Tumor Microenvironment in Helicobacter pylori-Induced Gastric Cancer

Mechanisms of the Epithelial–Mesenchymal Transition and Tumor Microenvironment in Helicobacter pylori-Induced Gastric Cancer

Helicobacter pylori among symptomatic Egyptian children: prevalence, risk factors, and effect on growth

Effect of Helicobacter pylori infection on growth trajectories in young Ethiopian children: a longitudinal study

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