<i>Helicobacter pylori</i> and gastrointestinal symptoms in school children in Russia

Nijevitch, Alexander A; Shcherbakov, Peter

doi:10.1111/j.1440-1746.2003.03316.x

Cited by 15 publications

(13 citation statements)

References 47 publications

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“…A similar association was observed in children from Russia, Greece, Pakistan, Tunisia, and Turkey (4,10,19,27,28,31,34), but no association was observed in other regions (3,14,22). These controversies suggest a possible role for either the geographical location of the population or the genetics of strains involved in the infection.…”

Section: Discussionmentioning

confidence: 56%

“…Many investigators have studied the criteria for diagnosis and treatment of children infected by H. pylori, but association of symptoms with H. pylori infection in children presenting with nonulcer dyspepsia is controversial (3,14,22). One important controversy relates to the presence of recurrent abdominal pain (RAP) in children, where an important association was observed between RAP and H. pylori infection in some populations (4,10,19,27,28,31,34). Although endoscopy-based tests are the best methods to diagnose active H. pylori infection, their application in children is more difficult and unpleasant than in adults.…”

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confidence: 99%

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Application of a Stool Antigen Test To Evaluate the Incidence ofHelicobacter pyloriInfection in Children and Adolescents from Tehran, Iran

Falsafi

Valizadeh

Sepehr

et al. 2005

Clin Vaccine Immunol

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Helicobacter pylori infection is acquired mainly in childhood, especially in developing countries, where a low-cost, rapid diagnostic technique which is reliable for all age groups may be useful for the management of H. pylori infection. For this purpose, we used an HpSA test (Equipar) to detect H. pylori infection in children and adolescents from Tehran, Iran. Thirty-five children who were positive or negative for H. pylori infection by endoscopy-based tests were used as positive and negative controls for the HpSA test. Stools were collected from 430 randomly selected children and adolescents (4 to 18 years old) from southwest, near the center, and northwest of Tehran. A questionnaire that included presence of recurrent abdominal pain (RAP), family history of infection and/or peptic ulcer disease (PUD), and income of parents was completed. A good agreement was found between the results of endoscopy-based tests and those of the HpSA test; the sensitivity and specificity of the Equipar-HpSA test were 100% and 83.4%, respectively. Among 430 children and adolescents, 47% were positive by the HpSA test, of whom 82% had RAP. No difference in incidence was observed between the two sexes; the various categories of age showed an increasing incidence, ranging from 24% (ages 4 to 6) to 58% (ages 16 to 18). The rate of infection in children and adolescents from the southwest was significantly higher (70%) than the rate in those from the northwest (32%), and a family history of H. pylori infection or PUD was observed in 59% of the HpSA positive subjects. The HpSA test is a useful test to detect H. pylori infection in children and adolescents from developing countries.Helicobacter pylori infection is acquired mainly in childhood, especially in developing countries (40), where the influence of socioeconomic factors on the prevalence of H. pylori infection has been shown (11,30,37). Many investigators have studied the criteria for diagnosis and treatment of children infected by H. pylori, but association of symptoms with H. pylori infection in children presenting with nonulcer dyspepsia is controversial (3,14,22). One important controversy relates to the presence of recurrent abdominal pain (RAP) in children, where an important association was observed between RAP and H. pylori infection in some populations (4,10,19,27,28,31,34). Although endoscopy-based tests are the best methods to diagnose active H. pylori infection, their application in children is more difficult and unpleasant than in adults. Moreover, in developing regions, for socioeconomic reasons, most infected children are not diagnosed and/or treated for H. pylori infection. To circumvent these difficulties, a noninvasive test with reliability for all age groups of children and adolescents is required. Among the noninvasive methods, serological tests cannot be applied to young children because of low sensitivity. In addition, the 13 C urea breath test is cumbersome, expensive, and consequently unavailable in certain countries; furthermore, it is not reliable in very...

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Section: Discussionmentioning

confidence: 56%

mentioning

confidence: 99%

Application of a Stool Antigen Test To Evaluate the Incidence ofHelicobacter pyloriInfection in Children and Adolescents from Tehran, Iran

Falsafi

Valizadeh

Sepehr

et al. 2005

Clin Vaccine Immunol

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“…Birçok çalışmada H. pylori ile TKA arasında ilişki bulunmamış ve TKA olan ço-cuklarda H. pylori taramasının gerekli olmadığı belirtilmiştir. [15][16][17][18][19][20] Kronik gastrik inflamasyonun sitokin salınımı aracılığı ile viseral hiperaljeziye yol açtığı ve H. pylori'nin rektoviseral gastrokolonik refleksin tetiklenmesinde rol alabileceği düşünül-mektedir. 8 Ülkemizde sağlıklı çocuklarda H. pylori sıklığı 13 C-üre nefes testi ile %50-56 olarak bulunmuştur, TKA'sı olan çocukların %36-49'unda ise H. pylori organik neden olarak bildirilmiştir.…”

Section: Bulgularunclassified

Recurrent Abdominal Pain in Children: Is it Organic or Functional?

Kırşaçlıoğlu¹,

Kuloğlu²,

Üstündağ³

et al. 2016

Turkiye Klinikleri J Pediatr

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74Çocuklarda Tekrarlayan Karın Ağrısı:Organik mi, Fonksiyonel mi?Ö ÖZ ZE ET T A Am ma aç ç: : Çocuklarda sık görülen bir durum olan tekrarlayan karın ağrısı organik ya da fonksiyonel olabilmektedir. Bu çalışmada, tekrarlayan karın ağrısına yol açan parazitozlar, çöl-yak hastalığı, idrar yolu enfeksiyonu, Helicobacter pylori enfeksiyonu gibi organik nedenlerin değerlendirilmesi ve fonksiyonel gastrointestinal bozuklukların belirlenmesi amaçlanmıştır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmaya başka bilinen bir hastalığı olmayan ve ilaç kullanmayan, en az üç ay süreyle en az üç kez tekrarlayan karın ağrısı olan çocuklar dâhil edildi. Ağrı karakteri, laboratuvar bulguları, radyolojik incelemeler, histopatolojik bulgular geriye dönük olarak değer-lendirildi. B Bu ul lg gu ul la ar r: : Çalışmaya ortalama yaşı 10,7±3,4 (4-17) yıl olan, ortanca 12 (3-20) aydır tekrarlayan karın ağrısı olan 151 (%57,6'sı kız) hasta alındı. Roma III kriterlerine göre; 81 (%53,6) hastada fonksiyonel gastrointestinal bozukluk, 70 (%46,4) hastada karın ağrısına yol açabilecek organik bir neden saptandı. Fonksiyonel ve organik nedenler arasında yaş, cinsiyet, ağrı süresi ve ağrı özellikleri açısından fark bulunmadı. Fonksiyonel gastrointestinal bozukluklar arasında en sık (%62,9) fonksiyonel karın ağrısı saptandı. Organik nedenli tekrarlayan karın ağrısı olan hastaların %46'sında Helicobacter pylori enfeksiyonu, %10,5'inde dışkıda parazit yumurtası, %3,9'unda biyopsi destekli çölyak hastalığı saptandı. S So on nu uç ç: : Fonksiyonel ve organik karın ağrısının ayırt edilmesinde yaş, cinsiyet, ağrı özellikleri, eşlik eden başka yakınmalar, fizik inceleme bulguları açısından bir fark saptanmamıştır. Çölyak hastalığı, tekrarlayan karın ağrısı olan bütün çocuklarda taranmalıdır.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Çocuk; çölyak hastalığı; karın ağrısı; Helicobacter pylori A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Recurrent abdominal pain is common in childhood, it may be functional or associated with organic disease. Evaluation of organic causes of recurrent abdominal pain such as parasitic enfestations, celiac disease, uriner tract infection, Helicobacter pylori infection and determine functional gastrointestinal disorders in children were aimed in the study. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Children with recurrent abdominal pain more than three times in frequency, for at least three months duration, without a known medical history and drug usage were recruited to study. Medical records were evaluated for pain characteristics, laboratory, radiological and histopathological findings, retrospectively. R Re es su ul lt ts s: : A hundred and fifty-one children [(57.6% female, mean age 10.7±3.4 (4-17) years] with recurrent abdominal pain for median 12 (3-20) months, were recruited to study. According to Rome III criteria; 81 (53.6%) patients had functional gastrointestinal disorders, 70 (46.4%) patients had an organic etiology. There was no difference between function...

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“…However, in other areas of Russia, the prevalence remains high. For example, a 2004 report in Ufa in the middle part of Russia found that H. pylori was present in 80% of 225 children with recurrent abdominal pain [9]. Overall, in Russia, H. pylori is still common as it is antimicrobial resistance.…”

Section: Introductionmentioning

confidence: 99%

“…Rather than being associated with acute infection, H. pylori infection is more commonly associated with chronic infections with long latent periods such as syphilis or tuberculosis where the outcomes are severe but many infected patients remain asymptomatic [13]. In children most H. pylori infections are asymptomatic and treatment is difficult because many antibiotics cannot be used in children, the rate of resistance to commonly used antibiotics is often high, and recurrences appear more likely [9, 14]. …”

Section: Introductionmentioning

confidence: 99%

Choosing Optimal Firstline Helicobacter pylori Therapy: a View from a Region with High Rates of Antibiotic Resistance

Nijevitch¹,

Idrisov²,

Ахмадеева³

et al. 2014

CPD

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Helicobacter pylori is a gram-negative, microaerophilic spiral bacillus that is associated with life-threatening diseases such as gastric cancer, gastric MALT lymphoma, and peptic ulcer disease. The definition of an effective therapy is one that achieves at least a 90% eradication rate on a per-protocol basis with the first attempt. Eradication rates of H. pylori have declined to unacceptable levels worldwide, mostly due to antibiotic resistance and standard triple therapy gradually has lost its efficacy in most counties. However, bismuth quadruple therapy, when prescribed properly, has maintained its effectiveness. Alternative first-line regimens such as sequential and concomitant therapy were developed to substitute for standard triple therapy and were highly effective in the countries where they were developed, but proved susceptible to failure in regions with high rates of antibiotic resistance. Antibiotic resistance rates in Russia are high, however there is lack of data regarding comparative efficacy of first-line eradication options. The authors of this review extrapolate the knowledge of H. pylori first-line eradication options in Russia based on data from other countries, as well as from domestic studies. The available data support use of 14-day regimens with concomitant therapy, bismuth quadruple therapy, or furazolidone quadruple therapy for empiric use in adults. In addition, 14-day levofloxacin-containing therapies could be used if resistance is relatively low or lacking as triple therapy or possibly as a 5-day concomitant levofloxacin therapy.

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Helicobacter pylori and gastrointestinal symptoms in school children in Russia

Abstract: The present results provide further evidence for a significant association between H. pylori and some patterns of gastrointestinal symptoms in children who underwent UGI endoscopy in order to exclude an organic cause of severe chronic gastrointestinal disorders.

Cited by 15 publications

References 47 publications

Application of a Stool Antigen Test To Evaluate the Incidence ofHelicobacter pyloriInfection in Children and Adolescents from Tehran, Iran

Application of a Stool Antigen Test To Evaluate the Incidence ofHelicobacter pyloriInfection in Children and Adolescents from Tehran, Iran

Recurrent Abdominal Pain in Children: Is it Organic or Functional?

Choosing Optimal Firstline Helicobacter pylori Therapy: a View from a Region with High Rates of Antibiotic Resistance

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