<i>Helicobacter</i>: Inflammation, immunology and vaccines

Robinson, Karen; Kaneko, Kazuyo; Andersen, Leif Percival

doi:10.1111/hel.12406

Cited by 10 publications

(9 citation statements)

References 49 publications

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“…HP infection often occurs in early childhood and will last a patient's whole life, whereas only a small percentage of HP-infected patients have obvious symptoms. [ 37 ] A complex balance between the human immune system and the HP after HP infection develops, resulting in a long state of chronic infection. [ 3 38 ]…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori Infection is Associated with Occurrence of Proteinuria in Type 2 Diabetes Patients

Shi

Duan

et al. 2018

Chinese Medical Journal

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Background:Type 2 diabetes (T2DM) patients are susceptible to Helicobacter pylori (HP), and it has been reported that the occurrence of proteinuria is associated with HP infection in T2DM patients; however, this view remains controversial. This meta-analysis aimed to explore the association between HP infection and the occurrence of proteinuria in T2DM patients. In addition, we hope to provide some recommendations to readers in clinical or related fields.Methods:Our meta-analysis was conducted with the methodology of the Cochrane Collaboration. Search strategies were formulated by relevant professionals. Case–control studies that compared the occurrence of proteinuria in T2DM patients with and without HP infection were involved in our meta-analysis. Relevant English or Chinese studies were searched on online databases before 2018, including PubMed, the Cochrane library, Medline, Google Scholar, the China National Infrastructure, and Wanfang database. The search strategies were “diabetic proteinuria, diabetic microalbuminuria, diabetic albuminuria, diabetic kidney disease, diabetic renal dysfunction, diabetic renal disease, diabetic nephropathy, diabetic complications, and diabetic mellitus, combined with HP.” The quality of these involved articles was separately assessed by two investigators using the Newcastle–Ottawa Scale (NOS). Odds ratios (ORs) and associated 95% confidence intervals (CIs) were extracted and pooled using fixed-effects models.Results:Seven studies involving 1029 participants were included. The quality of these seven articles was all above five stars as assessed by NOS, and there was no significant publication bias in our meta-analysis. We found that T2DM patients with HP infection had a 2.00 times higher risk of the occurrence of proteinuria than patients without HP infection (OR: 2.00, 95% CI: 1.48–2.69).Conclusions:Our analysis showed that HP infection was associated with the occurrence of proteinuria in T2DM patients. HP radical surgery might be a therapeutic option for protecting kidney function in patients with T2DM.

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Section: Discussionmentioning

confidence: 99%

Helicobacter pylori Infection is Associated with Occurrence of Proteinuria in Type 2 Diabetes Patients

Shi

Duan

et al. 2018

Chinese Medical Journal

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“…Even though both innate and acquired immune responses are activated in individuals infected with H. pylori, the host is unable to eradicate the bacteria, leading to a chronic lifelong infection (37,38). To escape the host's immune response and to survive in the hostile conditions found in the stomach, H. pylori has developed several strategies, including manipulating innate immune receptors and inhibiting effector T-cell responses (39,40).…”

Section: Helicobacter Pylori and Neurological Disordersmentioning

confidence: 99%

Helicobacter and the Potential Role in Neurological Disorders: There Is More Than Helicobacter pylori

et al. 2021

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Trillions of symbiotic microbial cells colonize our body, of which the larger part is present in the human gut. These microbes play an essential role in our health and a shift in the microbiome is linked to several diseases. Recent studies also suggest a link between changes in gut microbiota and neurological disorders. Gut microbiota can communicate with the brain via several routes, together called the microbiome–gut–brain axis: the neuronal route, the endocrine route, the metabolic route and the immunological route. Helicobacter is a genus of Gram-negative bacteria colonizing the stomach, intestine and liver. Several papers show the role of H. pylori in the development and progression of neurological disorders, while hardly anything is known about other Helicobacter species and the brain. We recently reported a high prevalence of H. suis in patients with Parkinson’s disease and showed an effect of a gastric H. suis infection on the mouse brain homeostasis. Here, we discuss the potential role of H. suis in neurological disorders and how it may affect the brain via the microbiome–gut–brain axis.

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“…H. pylori infects >50% of the world population and may affect gastric physiology, via triggering gastritis and canceration processes (3). Treatment of H. pylori infection may therefore help prevent GC in the general population (4,5); however, this treatment appears to be unrelated to the prognosis of patients with early GC (5,6). Gastric biopsy of patients with gastrointestinal-related symptoms demonstrated that in addition to the common H. pylori-related gastritis, several other modes of mucosal damage are also increasing (7).…”

Section: Introductionmentioning

confidence: 99%

IL10 hypomethylation is associated with the risk of gastric cancer

Tang

Pan

et al. 2021

Oncol Lett

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Interleukin-10 (IL10), a pleiotropic cytokine secreted by type-2 helper (Th2) T cells, contributes to the oncogenic activation or inactivation of tumor-suppressor genes. The present study investigated whether hypomethylation of IL10 CpG island (CGI) was associated with the risk of developing gastric cancer (GC) and the prognosis of patients with GC. A fragment (hg18, chr1: 206945638-206945774) at the CGI of IL10 was selected for the present methylation assay. Quantitative methylation-specific PCR was used to evaluate the methylation of IL10 CGI in 117 tumor samples from patients with GC. The results demonstrated that IL10 CGI methylation was significantly lower in the tumor tissues compared with that in the paired adjacent non-tumor tissues (median percentage of methylated reference, 29.16 vs. 42.82%, respectively; P=4×10 −8 ). Furthermore, results from receiver operating characteristic curve analysis identified a significant area under the curve of 0.706, with a sensitivity and a specificity of 77.8 and 58.1%, respectively, between cancer tissues and paired adjacent non-tumor tissues. Furthermore, the methylation of IL10 CGI was significantly associated with patients' age at diagnosis (r=−0.201; P=0.03). Subgroup analyses demonstrated that the association between IL10 CGI hypomethylation and the risk of GC was specific for patients with low differentiation (P=1×10 −7 ) and Borrmann types III+IV (P=1×10 −7 ). In addition, IL10 CGI hypomethylation was significantly associated with the risk of GC for patients without smoking history (P=3×10 −7 ) or a family history of cancer (P=2×10 −7 ). The results from Kaplan-Meier survival analysis demonstrated that IL10 CGI hypomethylation was associated with a significantly shorter overall survival of patients with GC (P=0.041). Similar results were identified for patients with GC who did not have smoking history (P=0.037) or a family history of cancer (P=0.049). The results from this study demonstrated that IL10 CGI hypomethylation may be considered as a potential biomarker for the diagnosis and prognosis of patients with GC in the Chinese population.

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Helicobacter: Inflammation, immunology and vaccines

Cited by 10 publications

References 49 publications

Helicobacter pylori Infection is Associated with Occurrence of Proteinuria in Type 2 Diabetes Patients

Helicobacter pylori Infection is Associated with Occurrence of Proteinuria in Type 2 Diabetes Patients

Helicobacter and the Potential Role in Neurological Disorders: There Is More Than Helicobacter pylori

IL10 hypomethylation is associated with the risk of gastric cancer

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