Helicobacter cinaedi
 Cellulitis and Bacteremia in Immunocompetent Hosts after Orthopedic Surgery

Kitamura, Toshio; Kawamura, Y.; Ohkusu, Kiyofumi; Masaki, Takayuki; Iwashita, Hirofumi; Sawa, Tomohiro; Fujii, Shigemoto; Okamoto, Tatsuya; Akaike, Takaaki

doi:10.1128/jcm.01507-06

Cited by 91 publications

(127 citation statements)

References 39 publications

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“…However, the possibility of nosocomial transmission of H. cinaedi has been suggested in some reports. Sufficient control of contact infection is necessary (10,11).…”

Section: Discussionmentioning

confidence: 99%

Recurrent Helicobacter cinaedi Cellulitis and Bacteremia in a Patient with Systemic Lupus Erythematosus

et al. 2012

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A 31-year-old woman who had developed systemic lupus erythematosus at 17 years of age was admitted to the hospital for suspected cellulitis in the lower extremities. A blood culture performed upon admission to the hospital detected Helicobacter cinaedi (H. cinaedi), which was also isolated in blood and fecal cultures obtained on the 42nd hospital day. Bacterial translocation of H. cinaedi present in the intestines may have led to the development of recurrent bacteremia and cellulitis. In cases such as this, appropriate antibiotics therapy might be needed for more than one month. Moreover, H. cinaedi, a cause of emerging infections, requires a long period of time to grow; therefore it is important to extend the culture duration when the presence of this bacterium is suspected.

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“…However, the possibility of nosocomial transmission of H. cinaedi has been suggested in some reports. Sufficient control of contact infection is necessary (10,11).…”

Section: Discussionmentioning

confidence: 99%

Recurrent Helicobacter cinaedi Cellulitis and Bacteremia in a Patient with Systemic Lupus Erythematosus

et al. 2012

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“…ince the first report of Helicobacter cinaedi in 1984 (1), it has been recognized as the most commonly reported enterohepatic Helicobacter species isolated from both immunocompromised (21) and immunocompetent (11,22) patients. Nonetheless, a rapid and specific assay for reliable diagnosis of H. cinaedi infection is still not available.…”

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confidence: 99%

Identification of and Screening for Human Helicobacter cinaedi Infections and Carriers via Nested PCR

et al. 2012

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bHelicobacter cinaedi is the most frequently reported enterohepatic Helicobacter species isolated from humans. Earlier research suggested that certain patients with H. cinaedi infection may remain undiagnosed or incorrectly diagnosed because of difficulties in detecting the bacteria by conventional culture methods. Here, we report a nested PCR assay that rapidly detects the cytolethal distending toxin gene (cdt) of H. cinaedi with high specificity and sensitivity. Specificity of the assay was validated by using different species of Helicobacter and Campylobacter, as well as known H. cinaedi-positive and -negative samples. The sensitivity of detection for the cdt gene in the assay was 10 2 CFU/ml urine or 10 2 CFU/10 5 infected RAW 264.7 cells. In an H. cinaedi-infected mouse model, the cdt gene of H. cinaedi was effectively detected via the assay with urine (6/7), stool (2/3), and blood (2/6) samples. Importantly, it detected H. cinaedi in blood, urine, and stool samples from one patient with a suspected H. cinaedi infection and three patients with known infections. The assay was further used clinically to follow up two H. cinaedi-infected patients after antibiotic treatment. Stool samples from these two patients evaluated by nested PCR after antibiotic therapy showed clearance of bacterial DNA. Finally, analysis of stool specimens from healthy volunteers showed occasional positive reactions (4/30) to H. cinaedi DNA, which suggests intestinal colonization by H. cinaedi in healthy subjects. In conclusion, this nested PCR assay may be useful for the rapid diagnosis, antimicrobial treatment evaluation, and epidemiological study of H. cinaedi infection.

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“…Although Helicobacter species are recognized as major pathogens associated with gastrointestinal tract infection, H. cinaedi is commonly isolated from compromised patients. [6][7][8]10) However, there have been increasing reports of infection in immunocompetent patients in whom H. cinaedi has been isolated from blood and caused recurrent bacteremia and latent or chronic infections. [6][7][8]10) Recently Lewis, et al 9) reported isolation of H. cinaedi from an immunocompetent patient with myopericarditis.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4][5] Helicobacter cinaedi is commonly isolated from compromised patients; however, there are increasing reports of this organism infecting immunocompetent patients. [6][7][8] H. cinaedi infection is reportedly associated with cardiovascular disease. 9,10) We here report a case of a pericoronary pseudotumor caused by H. cinaedi.…”

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confidence: 99%

Pericoronary Pseudotumor Caused by Helicobacter Cinaedi

et al. 2014

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SummaryCardiac tumors and tumor-like lesions are uncommon; most are true neoplasms. We here report a case of a pericoronary tumor-like lesion surrounding the right coronary artery in a 39-year-old man who presented with fever and chest pain. Although clarithromycin was administered for 1 week, his fever persisted. Helicobacter cinaedi (H. cinaedi) was isolated from blood cultures and found to be sensitive to ceftriaxone. A computed tomography scan showed a tumor-like lesion with no 18 F-fluorodeoxyglucose uptake surrounding the right coronary artery. After administration of ceftriaxone, the tumor-like lesion diminished in size according to meticulous computed tomography examinations. We therefore concluded that it was caused by H. cinaedi infection. The patient has been followed up closely for 1 year and remains asymptomatic. (Int Heart J 2014; 55: 463-465) Key words: Cardiac tumor, PET-CT P rimary cardiac tumors are uncommon; most are neoplasms. However, some tumor-like lesions are reactive, pseudoneoplastic masses. 1) Possible pathogenetic mechanisms include inflammation, autoimmune disorders, and infections.2-5) Helicobacter cinaedi is commonly isolated from compromised patients; however, there are increasing reports of this organism infecting immunocompetent patients. [6][7][8] H. cinaedi infection is reportedly associated with cardiovascular disease.9,10) We here report a case of a pericoronary pseudotumor caused by H. cinaedi. Case ReportA 39-year-old man presented to another institution with fever and chest pain. His white blood cell count was 19,440/ μL, and serum C-reactive protein concentration 11.2 mg/dL. Pneumonia was suspected and 400 mg of clarithromycin per day was administered orally for 1 week. However, his fever persisted and H. cinaedi was isolated from blood cultures, after which 2 g per day of intravenous ceftriaxone was substituted for clarithromycin for 2 weeks. Because infective endocarditis was suspected, transthoracic echocardiography was performed. This showed a mass on the lateral side of the right atrium and ventricle. A computed tomography (CT) scan showed a 5.8 × 4.2 cm tumor-like lesion around the right coronary artery (Figure 1). After he had received ceftriaxone for 2 weeks, the results of blood examinations returned to within normal limits and he was referred to our hospital for a suspected cardiac tumor.On presentation to our hospital, his physical examination was normal. White blood cell count was 4,720/μL with a normal differential count and the C-reactive protein concentration was within normal limits. Biochemical data, including serum immunoglobulin concentrations, were unremarkable. Tumor markers such as carcinoembryonic antigen, cancer antigens 19-9 and 125, α-fetoprotein, squamous cell carcinoma antigen, interleukin-6, and soluble interleukin-2R were all within normal limits. There was no evidence of immune deficiency and HIV serology was negative. Chest X-ray films showed no cardiomegaly or any other abnormalities. Electrocardiography showed normal sinus rhythm with...

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Helicobacter cinaedi Cellulitis and Bacteremia in Immunocompetent Hosts after Orthopedic Surgery

Cited by 91 publications

References 39 publications

Recurrent <i>Helicobacter cinaedi</i> Cellulitis and Bacteremia in a Patient with Systemic Lupus Erythematosus

Recurrent <i>Helicobacter cinaedi</i> Cellulitis and Bacteremia in a Patient with Systemic Lupus Erythematosus

Identification of and Screening for Human Helicobacter cinaedi Infections and Carriers via Nested PCR

Pericoronary Pseudotumor Caused by Helicobacter Cinaedi

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