<i>Healing</i> Tumors with Light: Science Fiction or <i>the</i> Future of Medicine?

Arany, Praveen

doi:10.1089/pho.2018.4457

Cited by 7 publications

(8 citation statements)

References 10 publications

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“…The ability to stimulate healing via cellular responses such as proliferation and migration has raised concerns on potential off-target effects on tumor cells. Several lines of evidence to date suggest that, while PBM has a modulatory effect on normal cellular responses, it appears to have an inhibitory response on tumor cells likely attributable to its inherently deranged metabolic and regulatory signaling [40]. These responses need to be carefully investigated further in well-designed labs and clinical studies.…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of Photobiomodulation Therapy in Improving Tissue Resilience and Healing of Radiation Skin Damage

et al. 2021

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The increased precision, efficacy, and safety of radiation brachytherapy has tremendously improved its popularity in cancer care. However, an unfortunate side effect of this therapy involves localized skin damage and breakdown that are managed palliatively currently. This study was motivated by prior reports on the efficacy of photobiomodulation (PBM) therapy in improving tissue resilience and wound healing. We evaluated the efficacy of PBM therapy on 36 athymic mice with 125I seed (0.42 mCi) implantation over 60 days. PBM treatments were performed with either red (660 nm) or near-infrared (880 nm, NIR) LEDs irradiance of 40 mW/cm2, continuous wave, fluence of 20 J/cm2 once per week. Animals were evaluated every 7 days with digital imaging, laser Doppler flowmetry, thermal imaging, µPET-CT imaging using 18F-FDG, and histology. We observed that both PBM treatments—red and NIR—demonstrated significantly less incidence and severity and improved healing with skin radionecrosis. Radiation exposed tissues had improved functional parameters such as vascular perfusion, reduced inflammation, and metabolic derangement following PBM therapy. Histological analysis confirmed these observations with minimal damage and resolution in tissues exposed to radiation. To our knowledge, this is the first report on the successful use of PBM therapy for brachytherapy. The results from this study support future mechanistic lab studies and controlled human clinical studies to utilize this innovative therapy in managing side effects from radiation cancer treatments.

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Section: Discussionmentioning

confidence: 99%

The Efficacy of Photobiomodulation Therapy in Improving Tissue Resilience and Healing of Radiation Skin Damage

et al. 2021

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“…These effects are broadly defined as photobiomodulation (PBM) 43 and consist of another important photomedicine which parallels PDT, PTT, and PIT. PBM in the context of cancer therapy typically involves no prior chemical or small‐molecule injection in the host to the therapy and uses endogenous photoabsorbers 45,46 . Because some studies showed that PBM stimulated the growth of cancer cells in vitro, it continues to be controversial whether PBM to tumor sites overall stimulates or suppresses cancer growth 47 .…”

Section: Cancer Photomedicinementioning

confidence: 99%

“…Interestingly, this effect was not observed in rho‐zero EMT6 tumors that lack functional mitochondria, which suggests mitochondrial involvement in PBM. PBM is also known to affect specific signaling via receptors including opsins, aryl hydrocarbons and growth factors including TGF‐β1, which has potential to significantly impact the fate of tumor cells 45 …”

Section: Cancer Photomedicinementioning

confidence: 99%

“…PBM is also known to affect specific signaling via receptors including opsins, aryl hydrocarbons and growth factors including TGF-β1, which has potential to significantly impact the fate of tumor cells. 45 Although the exact mechanisms are largely unclear, PBM appears to stimulate the immune system. In the HF-LPLI study, 53 as EMT6 tumors are highly immunogenic, long-term immunological memory was observed in the host.…”

Section: Photobiomodulationmentioning

confidence: 99%

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Quickly evolving near‐infrared photoimmunotherapy provides multifaceted approach to modern cancer treatment

Monaco

Yokomizo

Choi

et al. 2021

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Among modalities of cancer immunotherapy, near-infrared photoimmunotherapy (NIR-PIT) has reached significant preclinical and clinical stages and quickly evolved over the last 5 years. NIR-PIT uses deep-penetrable NIR light to induce physicochemical changes in the antibody-photosensitizer conjugate (APC), leading to resultant necrosis and immunogenic cell death (ICD) of the cancer cells. Alternatively, other types of photomedicine use photosensitizers to convert absorbed light energy either into reactive oxygen species for photodynamic therapy (PDT) or into heat for photothermal therapy (PTT). ICD is a unique and relevant outcome of NIR-PIT because it induces long-lasting antitumor host immunity, which overcomes the immunosuppressive network of cancer. Due to its high specificity and durable antitumor effects, NIR-PIT is now considered a promising cancer therapy, and optimized NIR-PIT is readily expanding its applicability to many different types of cancer. Along with the traditional method of NIR-PIT, new avenues in its realm of treatment are currently being explored, such as the targeting of other immunosuppressive elements, delivery of NIR light through a catheter, real-time imaging for tumor detection, and the use of tumor-seeking small molecules for improved efficacy and safety. In addition, its effect on hyperpermeability has opened a door for a wide array of combination therapies with other modalities. This review summarizes the recent findings in clinical and preclinical studies of NIR-induced photomedicine and its future significance in the field of cancer research.

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“…39,55,64–66,75–79 Similarly, there is no report that these wavelengths induce genotoxic changes, mutagenesis, or cancer, even in patients undergoing chemotherapy and who are receiving PBMT for prevention and management of oral mucositis. 81–92…”

Section: Safety Considerations Regarding Pbmt Of Vaginal Tissuementioning

confidence: 99%

The Rationale for Photobiomodulation Therapy of Vaginal Tissue for Treatment of Genitourinary Syndrome of Menopause: An Analysis of Its Mechanism of Action, and Current Clinical Outcomes

Lanzafame¹,

Torre²,

Leibaschoff³

2019

Photobiomodulation, Photomedicine, and Laser Surgery

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Objective: Light, particularly in the visible to far-infrared spectrum, has been applied to the female genital tract with lasers and other devices for nearly 50 years. These have included procedures on both normal and neoplastic tissues, management of condylomata, endometriosis, and menometrorrhagia, and, more recently, a number of fractional laser devices have been applied for the management of genitourinary syndrome of menopause (GSM) and stress urinary incontinence (SUI), and to achieve so-called vaginal rejuvenation. Photobiomodulation therapy (PBMT) has been proposed as an alternative for use in managing GSM and SUI. Methods: This article reviews the biological basis, symptoms, and management of GSM, and investigates the current status and rationale for the use of PBMT. Results and conclusions: Based on the preliminary evidence available, PBMT is safe and appears to be efficacious in treating GSM.

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Healing Tumors with Light: Science Fiction or the Future of Medicine?

Cited by 7 publications

References 10 publications

The Efficacy of Photobiomodulation Therapy in Improving Tissue Resilience and Healing of Radiation Skin Damage

The Efficacy of Photobiomodulation Therapy in Improving Tissue Resilience and Healing of Radiation Skin Damage

Quickly evolving near‐infrared photoimmunotherapy provides multifaceted approach to modern cancer treatment

The Rationale for Photobiomodulation Therapy of Vaginal Tissue for Treatment of Genitourinary Syndrome of Menopause: An Analysis of Its Mechanism of Action, and Current Clinical Outcomes

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