<i>Hartmanella Castellani</i>(Acanthamoeba SP.): Preliminary Report on Experimental Chemotherapy

Culbertson, C. G.; Holmes, D. H.; Overton, W. M.

doi:10.1093/ajcp/43.4.361

Cited by 41 publications

(6 citation statements)

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“…This may well have been due to cytosine residues in our cultures. We agree with Casemore that the activity of sulphonamides in vitro is weak and inconstant, although Culbertson et al (1965) found that sulphadiazine was protective in vivo for mice inoculated with A. castellanii Al.…”

Section: Discussionsupporting

confidence: 91%

“…Most of the reports on amoebicidal agents have been concerned with the treatment of Naegleria infections because of the predominance of Naegleria sp in primary amoebic meningoencephalitis (Carter, 1972), and only a few authors have discussed Acanthamoeba sensitivity (Culbertson et al, 1965;Cerva, 1969;Casemore, 1970) because the incidence of human infections is so very low and there has been little need for therapeutic information.…”

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confidence: 99%

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Chemotherapeutic compounds and Acanthamoebae from eye infections.

Nagington¹,

Richards²

1976

J Clin Pathol

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The amoebicidal and amoebistatic action in vitro of 24 compounds was tested on two strains of Acanthamoeba, A. polyphaga and A. castellanii, isolated from eye infections in this country. For comparison, the Ryan strain of A. castellanii and Naegleria gruberi L-1 were also examined. Nine compounds showed sufficient activity to merit further consideration, ie, acriflavine, proflavine, hydroxystilbamidine isethionate, paromomycin, miconazole, amphoterin, neomycin, polymyxin, and the last two combined in Neosporin.

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Section: Discussionsupporting

confidence: 91%

mentioning

confidence: 99%

Chemotherapeutic compounds and Acanthamoebae from eye infections.

Nagington¹,

Richards²

1976

J Clin Pathol

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“…In a mouse model, rifampin has been found to be effective (7 ). Sulfadiazine has been found to be protective in experimentally infected mice (8). The susceptibility to 5 -£uorocystosine has con-£icting reports (9^11).…”

Section: Discussionmentioning

confidence: 99%

A case of successful treatment of cutaneous Acanthamoeba infection in a lung transplant recipient

Walia

Montoya

Visvesvera

et al. 2007

Transplant Infectious Dis

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Acanthamoeba species are known to cause 2 well-described entities: (1) granulomatous amoebic encephalitis (GAE), which usually affects immunocompromised hosts, and (2) keratitis, which typically follows trauma associated with contamination of water or contact lenses. Less common manifestations include pneumonitis and a subacute granulomatous dermatitis. We describe a case of granulomatous dermatitis secondary to Acanthamoeba infection in a lung transplant recipient and a successful outcome following treatment with lipid formulation of amphotericin B and voriconazole. We believe this is the second case report describing disseminated Acanthamoeba infection in a lung transplant recipient. We also describe successful outcome with a combination of lipid formulation of amphotericin B and voriconazole, drugs that have not been previously reported to treat Acanthamoeba.

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“…A cutaneous Acanthamoeba infection in a patient with AIDS has been treated successfully with sulfadiazine [6]. Sulfadiazine and rifampicin also have been found to be effective in mouse models [7,8], however, in vitro neither sulfadiazine, nor rifampicin or fluconazole are able to eradicate Acanthamoeba trophozoites within 24 h. Although, several drugs have been reported to be successful in some cases, the same drugs were ineffective in other studies [9]. Moreover, in most cases cure was only achieved after a total excision of granulomatous lesions followed by antimicrobial therapy indicating that most amebae were eliminated surgically, and drug therapy was supportive.…”

Section: Discussionmentioning

confidence: 99%