<i>Haemophilus influenzae</i> receptor and the AnWj antigen

Poole, Joyce; Alphen, Loek van

doi:10.1046/j.1537-2995.1988.28388219164.x

Cited by 18 publications

(17 citation statements)

References 4 publications

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“…This suggests that the sisters' antibodies may have been stimulated by pregnancy. The AnWj antigen is not expressed on red cells until between 3 and 42 days after birth (Poole & van Alphen, 1988), although we have shown in this study that cord cells are capable of absorbing and eluting anti-AnWj. There was no clinical evidence of anti-AnWj causing HDN in any of the children of either sister.…”

Section: Number Of Examples In Parenthesiscontrasting

confidence: 62%

A family showing inheritance of the Anton blood group antigen An Wj and independence of An Wj from Lutheran

Poole

Levene²,

Bennett

et al. 1991

Transfusion Medicine

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A 43-year-old Arab woman was found to be negative for the high incidence AnWj antigen and her serum contained anti-AnWj. Two of her seven siblings were also AnWj-negative, which provides evidence for the first time that the AnWj-negative phenotype may be an inherited character. Blood groups of the family, in which the parents of the proposita are consanguineous, show that AnWj is not part of the ABO, Rh, MNSs, Kell, Duffy, Kidd, Xg and, notably, Lutheran blood group systems and neither is it X or Y linked.

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Section: Number Of Examples In Parenthesiscontrasting

confidence: 62%

A family showing inheritance of the Anton blood group antigen An Wj and independence of An Wj from Lutheran

Poole

Levene²,

Bennett

et al. 1991

Transfusion Medicine

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“…AnWj is thought to be carried on the CD44 proteoglycan and possibly resides on the glycosylated region encoded by exons 5 and 15 . The AnWj antigen acts as the receptor for Haemophilus influenzae . RBCs of newborns do not or weakly express the AnWj antigen.…”

Section: Introductionmentioning

confidence: 99%

“…RBCs of newborns do not or weakly express the AnWj antigen. Transition from AnWj‐negative to AnWj‐positive phenotype occurs 3‐46 days after birth and is completed within 24‐48 hours …”

Section: Introductionmentioning

confidence: 99%

“…Transition from AnWj-negative to AnWj-positive phenotype occurs 3-46 days after birth and is completed within 24-48 hours. 4 Antibodies to AnWj are extremely rare; in some individuals' transient suppression of the AnWj antigen on the patient's own RBCs results in the formation of anti-AnWj. Such events were reported in association with lymphoid malignancies, immunologic disorders, and autoimmune hemolytic anemia.…”

Section: Introductionmentioning

confidence: 99%

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SMYD1 is the underlying gene for the AnWj‐negative blood group phenotype

Yahalom

Pillar

Zhao

et al. 2018

European J of Haematology

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“…1990), with only the so-called LKP fimbriae being associated with adherence to human cells (Brinton et ai, 1989). They agglutinate erythrocytes carrying the AnWj-antigen (van Alphen et ai, 1986;Poole and van Alphen, 1988) and confer binding of the bacteria to sialic-acid-containing lactosylceramide structures on oropharyngeal epithelial cells (van Alphen etai, 1991). LKP fimbriae contribute to colonization of the nasopharynx, which is thought to be a prerequisite for the development of both local (chronic bronchitis or otitis media) and systemic (meningitis) H. /nffuenzae infections (Loos etai, 1989;Moxon, 1986;Murphy and Sethi, 1992).…”

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confidence: 99%

The fimbrial gene cluster of Haemophilus influenzae type b

Ham

Alphen

Mool

et al. 1994

Molecular Microbiology

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Haemophilus influenzae infections are preceded by airway colonization, a process facilitated by fimbriae. Here, we identified the complete fimbrial gene cluster of H. influenzae type b. HifA forms the major subunit. HifB, a periplasmic chaperone, and HifC, an outer membrane usher, are typical assembly genes; their inactivation abolished fimbriae formation. HifD and HifE are putative minor subunits, both participating in fimbriae biogenesis. Inactivation of either one drastically reduced fimbriae expression. HifD represents a novel type of fimbrial subunit with lipoprotein characteristics, pointing to a membrane-associated function of HifD. Transcription of all fimbrial genes is coregulated through two clustered promoters. The flanking of the fimbrial gene cluster by repetitive extragenic palindromic sequences together with a partial duplication of an adjacent unrelated operon indicated that the cluster was once inserted in the H. influenzae genome as a mobile virulence unit.

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Haemophilus influenzae receptor and the AnWj antigen

Cited by 18 publications

References 4 publications

A family showing inheritance of the Anton blood group antigen An Wj and independence of An Wj from Lutheran

A family showing inheritance of the Anton blood group antigen An Wj and independence of An Wj from Lutheran

SMYD1 is the underlying gene for the AnWj‐negative blood group phenotype

The fimbrial gene cluster of Haemophilus influenzae type b

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