<i>Haemophilus</i>

and, T. J. Inzana; Corbeil, L. B.

doi:10.1002/9780470344903.ch18

Cited by 9 publications

(12 citation statements)

References 61 publications

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“…However, we have described the production of an exopolysaccharide (22), which is a common component of bacterial biofilms. Therefore, we sought to determine whether H. somni produced a biofilm and, if so, characterize the formation of this biofilm by pathogenic and commensal strains.…”

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confidence: 99%

“…H. somni is one of the pathogens responsible for bovine respiratory disease complex, which is responsible for 61.5% of the mortality in North American feedlot cattle, as well as decreased weight gain and morbidity in an additional 10% of these animals (34). In addition to pneumonia (2,13,21), H. somni can cause meningoencephalitis, myocarditis, arthritis, septicemia, and other systemic infections (7,22). H. somni expresses a wide array of virulence factors, including phase variation of lipooligosaccharide epitopes (20,24,25,52), decoration of lipooligosaccharide with sialic acid and phosphorylcholine (20,24,43), expression of high-molecular-weight immunoglobulin-binding proteins (5,6,51), intracellular survival in professional phagocytes (8,33), and induction of apoptosis (46,47).…”

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confidence: 99%

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Characterization and Comparison of Biofilm Development by Pathogenic and Commensal Isolates of Histophilus somni

et al. 2007

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Histophilus somni (Haemophilus somnus) is an obligate inhabitant of the mucosal surfaces of bovines and sheep and an opportunistic pathogen responsible for respiratory disease, meningoencephalitis, myocarditis, arthritis, and other systemic infections. The identification of an exopolysaccharide produced by H. somni prompted us to evaluate whether the bacterium was capable of forming a biofilm. After growth in polyvinyl chloride wells a biofilm was formed by all strains examined, although most isolates from systemic sites produced more biofilm than commensal isolates from the prepuce. Biofilms of pneumonia isolate strain 2336 and commensal isolate strain 129Pt were grown in flow cells, followed by analysis by confocal laser scanning microscopy and scanning electron microscopy. Both strains formed biofilms that went through stages of attachment, growth, maturation, and detachment. However, strain 2336 produced a mature biofilm that consisted of thick, homogenous mound-shaped microcolonies encased in an amorphous extracellular matrix with profound water channels. In contrast, strain 129Pt formed a biofilm of cell clusters that were towershaped or distinct filamentous structures intertwined with each other by strands of extracellular matrix. The biofilm of strain 2336 had a mass and thickness that was 5-to 10-fold greater than that of strain 129Pt and covered 75 to 82% of the surface area, whereas the biofilm of strain 129Pt covered 35 to 40% of the surface area. Since H. somni is an obligate inhabitant of the bovine and ovine host, the formation of a biofilm may be crucial to its persistence in vivo, and our in vitro evidence suggests that formation of a more robust biofilm may provide a selective advantage for strains that cause systemic disease.

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confidence: 99%

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confidence: 99%

Characterization and Comparison of Biofilm Development by Pathogenic and Commensal Isolates of Histophilus somni

et al. 2007

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“…Possible interactions with other bacteria present in the area may further enhance infection (Inzana and Corbeil, 2004;Al-Katib and Dennis, 2009). Virulence determinants of these organisms include epithelial colonisation, invasion, host-cell damage and evasion of the host response, although differences among strains have been identified in the possession of these factors (Inzana and Corbeil, 2004). Pathogenicity of the various strains depends on their ability to achieve epithelial colonisation, to cause apoptosis in the host animal, to invade the epithelial cells and to evade host's defences.…”

Section: Epididymitis Associated With Actinobacillus Seminis or Histomentioning

confidence: 99%

“…The organisms are part of the bacterial flora in the prepuce, becoming opportunistic pathogens under favourable conditions, e.g., hormonal factors such as increased concentration of luteinising or follicle-stimulating hormone occurring during puberty, supporting an ascending infection by the organisms. Possible interactions with other bacteria present in the area may further enhance infection (Inzana and Corbeil, 2004;Al-Katib and Dennis, 2009). Virulence determinants of these organisms include epithelial colonisation, invasion, host-cell damage and evasion of the host response, although differences among strains have been identified in the possession of these factors (Inzana and Corbeil, 2004).…”

Section: Epididymitis Associated With Actinobacillus Seminis or Histomentioning

confidence: 99%

“…Pathogenicity of the various strains depends on their ability to achieve epithelial colonisation, to cause apoptosis in the host animal, to invade the epithelial cells and to evade host's defences. Clinical disease is the conclusion of cellular apoptosis (result of endotoxin secretion) and local inflammatory reaction (Inzana and Corbeil, 2004).…”

Section: Epididymitis Associated With Actinobacillus Seminis or Histomentioning

confidence: 99%

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