<i>Haemophilus</i>

Slack, Mary

doi:10.1002/9780470688618.taw0065

Cited by 2 publications

(3 citation statements)

References 307 publications

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“…Localized infections such as pneumonia were included if accompanied by a sterile site isolate. Isolates were confirmed as H. influenzae by growth requirement for X and V factors ( 20 ) and ompP2 -specific PCR positivity ( 21 ). Capsulation status was determined by PCR by using bexA -specific primers ( 22 ).…”

Section: Methodsmentioning

confidence: 99%

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InvasiveHaemophilus influenzaeSerotype e and f Disease, England and Wales

Ladhani¹,

Collins²,

Vickers³

et al. 2012

Emerg. Infect. Dis.

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Section: Methodsmentioning

confidence: 99%

“…Capsulation status was determined by PCR by using bexA -specific primers ( 22 ). Capsular type was confirmed by capsule-specific PCR by using primers for types Hia–Hif ( 23 ) and slide agglutination ( 20 ).…”

Section: Methodsmentioning

confidence: 99%

InvasiveHaemophilus influenzaeSerotype e and f Disease, England and Wales

Ladhani¹,

Collins²,

Vickers³

et al. 2012

Emerg. Infect. Dis.

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“…Haemophilus influenzae (Hi) is usually regarded as a strict human pathogen without any animal reservoir and can be divided into those encapsulated with a polysaccharide capsule and those non-encapsulated ( 1 ). Those with capsules can be divided into six capsular types called serotypes (a–f) using specific antisera raised against the unique chemical structure of each capsular type, and non-encapsulated strains are regarded as non-typeable (NT) ( 2 ).…”

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Laboratory characterization of invasiveHaemophilus influenzaeisolates from Nunavut, Canada, 2000–2012

Tsang

Mullen

et al. 2016

International Journal of Circumpolar Health

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BackgroundWith invasive Haemophilus influenzae serotype b (Hib) disease controlled by vaccination with conjugate Hib vaccines, there is concern that invasive disease due to non-serotype b strains may emerge.ObjectiveThis study characterized invasive H. influenzae (Hi) isolates from Nunavut, Canada, in the post-Hib vaccine era.MethodsInvasive H. influenzae isolates were identified by conventional methods at local hospitals; and further characterized at the provincial and federal public health laboratories, including detection of serotype antigens and genes, multi-locus sequence typing and antibiotic susceptibility.ResultsOf the 89 invasive H. influenzae cases identified from 2000 to 2012, 71 case isolates were available for study. There were 43 serotype a (Hia), 12 Hib, 2 Hic, 1 Hid, 1 Hie, 2 Hif and 10 were non-typeable (NT). All 43 Hia were biotype II, sequence type (ST)-23. Three related STs were found among the Hib isolates: ST-95 (n=9), ST-635 (n=2) and ST-44 (n=1). Both Hif belonged to ST-124 and the 2 Hic were typed as ST-9. The remaining Hid (ST-1288) and Hie (ST-18) belonged to 2 separate clones. Of the 10 NT strains, 3 were typed as ST-23 and the remaining 7 isolates each belonged to a unique ST. Eight Hib and 1 NT-Hi were found to be resistant to ampicillin due to β-lactamase production. No resistance to other antibiotics was detected.ConclusionDuring the period of 2000–2012, Hia was the predominant serotype causing invasive disease in Nunavut. This presents a public health concern due to an emerging clone of Hia as a cause of invasive H. influenzae disease and the lack of published guidelines for the prophylaxis of contacts. The clonal nature of Hia could be the result of spread within an isolated population, and/or unique characteristics of this strain to cause invasive disease. Further study of Hia in other populations may provide important information on this emerging pathogen. No antibiotic resistance was detected among Hia isolates; a small proportion of Hib and NT-Hi isolates demonstrated resistance to ampicillin due to β-lactamase production.

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Haemophilus

Cited by 2 publications

References 307 publications

InvasiveHaemophilus influenzaeSerotype e and f Disease, England and Wales

InvasiveHaemophilus influenzaeSerotype e and f Disease, England and Wales

Laboratory characterization of invasiveHaemophilus influenzaeisolates from Nunavut, Canada, 2000–2012

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