<i>H-2</i>-LINKED GENETIC CONTROL OF IMMUNE RESPONSIVENESS TO OVALBUMIN AND OVOMUCOID

Vaz, Nelson M.; Phillips‐Quagliata, Julia M.; Levine, Bernard B.; Vaz, Elenice Maria Cecchetti

doi:10.1084/jem.134.5.1335

Cited by 97 publications

(49 citation statements)

References 23 publications

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“…It has been demonstrated that induction of a specific IgE antibody is invariably accompanied by induction of an antigen-specific IgG (Vaz et al, 1970(Vaz et al, , 1971Yamanishi et al, 2003). This is especially the case for sub-classes of IgG that are regulated in a manner similar to IgE (as surrogates for IgE).…”

Section: Discussionmentioning

confidence: 99%

Allergic reactions compared between BN and Wistar rats after oral exposure to ovalbumin

Sun¹,

Zhou²,

Pu³

et al. 2012

Journal of Immunotoxicology

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Section: Discussionmentioning

confidence: 99%

Allergic reactions compared between BN and Wistar rats after oral exposure to ovalbumin

Sun¹,

Zhou²,

Pu³

et al. 2012

Journal of Immunotoxicology

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“…Finally, Merryman (personal communication) has shown that the ability of mice to respond to the linear synthetic polypeptide GAT10 is also a property of the K region of the H-2 complex. Vaz et al (26) have also shown that the ability to respond to low doses of ovomucoid and bovine 3'-globulin is a property of the K region of the H-2 complex. In each of these cases, localization was accomplished through the use of H-2 recombinants produced by Stimpfling from crossovers between H-2 '~ and H-2 b.…”

Section: Discussionmentioning

confidence: 99%

Genetic Control of the Immune Response

McDevitt

Deak

Shreffler

et al. 1972

The Journal of Experimental Medicine

321

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Eleven strains of mice bearing recombinant H-2 chromosomes derived from known crossover events between known H-2 types were immunized with a series of branched, multichain, synthetic polypeptide antigens [(T,G)-A--L, (H,G)-A--L, and (Phe,G)-A--L]. Results with nine of the eleven H-2 recombinants indicated that the gene(s) controlling immune response to these synthetic polypeptides (Ir-1) is on the centromeric or H-2K part of the recombinant H-2 chromosome. Results with two of the eleven recombinant H-2 chromosomes indicated that Ir-1 was on the telomeric or H-2D part of the recombinant H-2 chromosome. Both of these recombinants were derived from crossovers between the H-2K locus and the Ss-Slp locus near the center of the H-2 region. One of these recombinants, H-2y, was derived from a known single crossover event. These results indicate that Ir-1 lies near the center of the H-2 region between the H-2K locus and the Ss-Slp locus. The results of a four-point linkage test were consistent with these results. In 484 offspring of a cross designed to detect recombinants between H-2 and Ir-1, only two putative recombinants were detected. Both of these recombinants were confirmed by progeny testing. Extensive analysis of one of them has shown that the crossover event occurred within the H-2 region. (Testing of the second recombinant is currently under way.) Thus, in the linkage test, recombinants between H-2 and Ir-1 are in fact intra-H-2 crossovers. These results permit assignment of Ir-1 to a position between the H-2K locus and the Ss-Slp locus.

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“…For more complex immunogens, genetic regulation of responsiveness in this species has been reported for limiting immunogenic doses of certain proteins (9,10). This dose-dependent expression of Ir genes was attributed to immunological stimulation by those determinants which were both most immunopotent and under the control of a specific If gene (25).…”

Section: Discussionmentioning

confidence: 99%

Genetic Control of the Immune Response to Staphylococcal Nuclease

Lozner

Sachs

Shearer

1974

The Journal of Experimental Medicine

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A number of inbred and congenic resistant strains of mice were immunized with staphylococcal nuclease (Nase). Antibody responses were measured in the sera of the animals by a sensitive method involving inhibition of enzymatic hydrolysis of DNA, High responder strains included A/J, DBA/2, BALB/c, AKR/J, C57BR, and SJL/J. DBA/1 and C57BL/6 mice were low responders. The strain distribution of anti-Nase response potential was compatible with the relevant immune response gene(s) being linked to the murine major histocompatibility complex. Linkage of this response to H-2 was demonstrated by the findings that: (a) the congenic C3H/HeJ and C3H.SW mice were respectively high and low responders; (b) the congenic lines B10.A and B10.D2 were high responders, whereas the C57BL/10 strain was a poor responder; and (c) anti-Nase response potential of F2 progeny from DBA/1 x SJL/J matings correlated with their H-2 type. Three B10.A recombinant lines were used to map this Ir gene within H-2. B10.A(4R) was a high responder to Nase, whereas B10.A(2R) and B10.A(5R) were both low responders. We wish to propose the name Ir-Nase for the gene(s) controlling antibody responsiveness to this immunogen. Our data indicate that Ir-Nase is located within the same chromosomal segment of the H-2 complex as is Ir-IgG.

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H-2-LINKED GENETIC CONTROL OF IMMUNE RESPONSIVENESS TO OVALBUMIN AND OVOMUCOID

Cited by 97 publications

References 23 publications

Allergic reactions compared between BN and Wistar rats after oral exposure to ovalbumin

Allergic reactions compared between BN and Wistar rats after oral exposure to ovalbumin

Genetic Control of the Immune Response

Genetic Control of the Immune Response to Staphylococcal Nuclease

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