GPC6 Promotes Cell Proliferation, Migration, and Invasion in Nasopharyngeal Carcinoma

Abstract

Nasopharyngeal carcinoma (NPC) is a highly metastatic tumor that occurs frequently in Southeast Asia, particularly including southern China. Epstein-Barr virus infection is well established as a primary cause of NPC; nevertheless, the mechanisms underlying NPC pathogenesis remain largely unknown. In our previous study, we conducted whole-genome sequencing to screen for genomic variations that were associated with NPC. Of the resultantly identified variations, glypican-6 (GPC6), was shown, for the first time, to be frequently mutated in NPC. In the present study, we verified this finding and conducted a series of functional experiments, which demonstrated that GPC6 promotes the migration, invasion, and proliferation of NPC cells in vitro. Thus, the present study identified novel biological functions for GPC6 in NPC, and thus, showed that GPC6 may be a promising potential therapeutic target for this disease.

The BRAF V600E mutation is a predictor of the effect of radioiodine therapy in papillary thyroid cancer

“…Studies have suggested that patients with the BRAF V600E mutation should be overtreated to some extent [47], because BRAF mutations are an independent risk factor for lymph node metastasis and are closely related to tumor size and invasiveness [48][49][50][51][52][53][54][55][56][57]. Both the clinical studies and the basic medical studies performed here suggest that the presence of the BRAF mutation may lead to a decrease in the efficacy of iodine-131 treatment.…”

Long non-coding RNA PVT1 interacts with MYC and its downstream molecules to synergistically promote tumorigenesis

“…One mechanism is to connect linearly distant loci with proteins, such as CTCF. In the other mechanism, for the topologically associated domain (TAD) scaffold, contact between the promoter and enhancer can coordinate the regulation of gene expression [75,76]. Promoter-enhancer competition between PVT1 and MYC, described as follows, mainly occurs in the TAD.…”

LncRNA AATBC regulates Pinin to promote metastasis in nasopharyngeal carcinoma

“…Although NPC is sensitive to radiotherapy with adjuvant chemotherapy (Ge et al ., 2020; He et al ., 2018; Tang et al ., 2018a), most NPC patients often have metastases at the time of diagnosis. Hence, the prognosis of these patients is poor (Fan et al ., 2019b; Peng et al ., 2019; Ren et al . 2020; Wang et al ., 2019a; Wei et al ., 2018a,b; Xiong et al ., 2019).…”