Giardia intestinalisdeoxyadenosine kinase has a unique tetrameric structure that enables high substrate affinity and makes the parasite sensitive to deoxyadenosine analogues
Farahnaz Ranjbarian,
Karim Rafie,
Kasturika Shankar
et al.
Abstract:Giardia intestinalisis a protozoan parasite causing giardiasis, a severe, sometimes even life-threatening, diarrheal disease.Giardiais one of only a few known organisms that lackde novosynthesis of DNA building blocks, and the parasite is therefore completely dependent on salvaging deoxyribonucleosides from the host. The deoxyribonucleoside kinases (dNKs) needed for this salvage are generally divided into two structurally distinct families, thymidine kinase 1 (TK1)-like dNKs and non-TK1-like dNKs. We have char… Show more
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