gem‐Bisphosphonate‐Ended Group Dendrimers: Design and Gadolinium Complexing Properties

Abstract

The synthesis of the first gem-bisphosphonate-ended group dendrimers is described using nucleophilic substitution of terminal P(S)Cl 2 units of phosphorus dendrimers of generation 1 to 3 with protected aminophenols followed by deprotection of amino groups and Michael addition with vinyl-

Divergent Synthesis of (Benzo[b][1,4]diazepin‐2‐yl)phosphonates and (Quinoxalin‐2‐yl)methylphosphonates from Phosphoryl‐Substituted Conjugated Ynones

“…The authors have cited additional references within the Supporting Information. [15][16][17][18][19]…”

CHAPTER 6. Poly(phosphorhydrazone) Dendrimers and Other Phosphorus-containing Dendrimers

“…Various types of phosphines 54,55 and pyridine-imine ligands, 31,56,57 all of them used subsequently for the complexation of diverse metal derivatives, phosphonates [58][59][60][61][62] and carboxylates, 63,64 carbohydrates 65 and fluorescent derivatives 47,[66][67][68][69] have been grafted in this way. Other series concern diverse ferrocene derivatives, 27,28,[70][71][72][73] triazole derivatives obtained by "click" reactions, 50,74,75 piperazine derivatives, [76][77][78] and long chains. 79,80 Other phenol phosphines, 17,40,81,82 phenol ligands, [83][84][85] phenol fluorophores, 86,87 and miscellaneous phenol derivatives 24,50,[88][89][90][91]…”

Phosphorhydrazones as Useful Building Blocks for Special Architectures: Macrocycles and Dendrimers

“…Other functionalized phenols comprise ligands for catalysis, such as phosphine, and diphosphine, iminophosphine, aminophosphine, diketone, pyridineimine, terpyridine, bisoxazoline, prolinol derivative, and cinchonine, diverse other compounds, such as aminophosphoniums, thioesters and thioamides, two types of ethacrynic derivatives,, long chains of type alkyl or perfluoroalkyl, or PEG (polyethyleneglycol), and fluorescent groups based on stilbazole or fluorene derivatives , . Miscellaneous functions are nitrile and dimethylamino, or alkyne and azide, or d ‐xylose, or ammonium (Figure ). Attempts to graft specifically two different phenols have been assayed, as shown by the reaction of a phenol ethacrynic derivative and hydroxybenzaldehyde or azabisphosphonate tyramine, but contrarily to amines (see below), the reaction is not totally specific …”