<i>Gastrodia elata</i> Bl. Attenuated Learning Deficits Induced by Forced-Swimming Stress in the Inhibitory Avoidance Task and Morris Water Maze

Chen, Pei Ju; Liang, Keng Chen; Lin, Han; Hsieh, Ching Liang; Su, Kuan‐Pin; Hung, Mei Chu; Sheen, Lee‐Yan

doi:10.1089/jmf.2010.1209

Cited by 27 publications

(13 citation statements)

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“…), Tall Gastrodia (from Gastrodiaelata elata ), and Ginkgo (from Ginkgo biloba ) also have anti-hypoxia functions [11–14], and these TCMs could potentially be used for treating hypoxia related diseases. In fact, Herba Rhodiolae, which has long been used by the Tibetan people as a powerful medicinal agent to counter the high altitude hypobaric hypoxia [15,16], has been reported to show anti-depression effects [17].…”

Section: Introductionmentioning

confidence: 99%

Metabolomic Analysis of Anti-Hypoxia and Anti-anxiety Effects of Fu Fang Jin Jing Oral Liquid

et al. 2013

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BackgroundHerba Rhodiolae is a traditional Chinese medicine used by the Tibetan people for treating hypoxia related diseases such as anxiety. Based on the previous work, we developed and patented an anti-anxiety herbal formula Fu Fang Jin Jing Oral Liquid (FJJOL) with Herba Rhodiolae as a chief ingredient. In this study, the anti-hypoxia and anti-anxiety effects of FJJOL in a high altitude forced-swimming mouse model with anxiety symptoms will be elucidated by NMR-based metabolomics.MethodsIn our experiments, the mice were divided randomly into four groups as flatland group, high altitude saline-treated group, high altitude FJJOL-treated group, and high altitude diazepam-treated group. To cause anxiety effects and hypoxic defects, a combination use of oxygen level decreasing (hypobaric cabin) and oxygen consumption increasing (exhaustive swimming) were applied to mice. After a three-day experimental handling, aqueous metabolites of mouse brain tissues were extracted and then subjected to NMR analysis. The therapeutic effects of FJJOL on the hypobaric hypoxia mice with anxiety symptoms were verified.ResultsUpon hypoxic exposure, both energy metabolism defects and disorders of functional metabolites in brain tissues of mice were observed. PCA, PLS-DA and OPLS-DA scatter plots revealed a clear group clustering for metabolic profiles in the hypoxia versus normoxia samples. After a three-day treatment with FJJOL, significant rescue effects on energy metabolism were detected, and levels of ATP, fumarate, malate and lactate in brain tissues of hypoxic mice recovered. Meanwhile, FJJOL also up-regulated the neurotransmitter GABA, and the improvement of anxiety symptoms was highly related to this effect.ConclusionsFJJOL ameliorated hypobaric hypoxia effects by regulating energy metabolism, choline metabolism, and improving the symptoms of anxiety. The anti-anxiety therapeutic effects of FJJOL were comparable to the conventional anti-anxiety drug diazepam on the hypobaric hypoxia mice. FJJOL might serve as an alternative therapy for the hypoxia and anxiety disorders.

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Section: Introductionmentioning

confidence: 99%

Metabolomic Analysis of Anti-Hypoxia and Anti-anxiety Effects of Fu Fang Jin Jing Oral Liquid

et al. 2013

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“…In this model, the concentrations of serotonin and dopamine were elevated, while the turnover of these two monoamines was decreased after orally GE treatment 71) . Furthermore, the water extract of GE attenuated memory impairment loss by the animals as measured by the inhibitory avoidance task and the Morris water maze in rats 73) . This is a significant finding, as memory impairment is a common problem that affects patients with depression.…”

Section: Discussionmentioning

confidence: 88%

Antidepressant-like Effects of the Gastrodia elata Bl Extract in Mice

Hong¹,

Cho²

2013

Journal of Oriental Neuropsychiatry

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Objectives :A growing body of evidence has suggested that the dysfunction of glutamatergic systems plays a pivotal role in major depressive disorder (MDD). This study was performed to investigate the antidepressant-like effects of the ethanolic extract of Gastrodia elata Bl (GE) in mouse models and to investigate the role of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors in producing these antidepressant-like effects. Methods :The forced swim test (FST) and tail suspension test (TST) were used to investigate GE's behavioral effects in mice. Additional biochemical and behavioral experiments with NBQX, an AMPA receptor antagonist, were undertaken to determine whether the antidepressant-like properties of GE are involved in AMPA receptor throughput. Results :Oral administration of GE extract (1,600 mg/kg) 1h prior to testing significantly reduced the immobility times in the FST and TST. These antidepressant-like effects of GE extract were increased dose-dependently. Pre-treatment with NBQX significantly attenuated the reduction in immobility time induced by the GE extract in the FST and TST. Conclusions :The ethanolic extract of GE may exert antidepressant-like effects with involvement of AMPA receptor.

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“…Indeed, as described above, GE and its active principles have come to light, and extensive research in preventing neurotoxicity and neurodegeneration has been initiated. For instance, GE was experimentally shown to prevent ischemia injury (Zeng et al, 2006), Alzheimer's disease (AD; Kim et al, 2007), and PD (An et al, 2010) and improve learning and memory (Chen et al, 2011). These data further highlight the neuroprotective effects of GE.…”

Section: Introductionmentioning

confidence: 79%