<i>Ganoderma lucidum</i>
 (Reishi mushroom) for cancer treatment

Jin, Xingzhong; Beguerie, Julieta Ruíz; Sze, Daniel Man-yeun; Chan, Godfrey C. F.

doi:10.1002/14651858.cd007731.pub3

Cited by 101 publications

(75 citation statements)

References 30 publications

(15 reference statements)

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“…Among these five RTCs, four studies showed that patients treated with G. lucidum had relatively improved quality of life compared to controls (73). Our study also showed that BSGLWE protected tumor-bearing mice from weight loss and reduced the degree of malignancy compared to 5-FU or control groups.…”

Section: Discussionmentioning

confidence: 99%

Anticarcinogenic effects of water extract of sporoderm-broken spores of Ganoderma lucidum on colorectal cancer in vitro and in vivo

Sang

et al. 2017

International Journal of Oncology

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Ganoderma lucidum (G. lucidum) polysaccharides (GLPs) have been used as traditional Chinese medicine for cancer prevention for many years. However, the mechanism by which GLP exerts its chemopreventive activities remains elusive. In addition, it is unclear whether sporoderm-broken spores of G. lucidum water extract (BSGLWE), which contains mainly GLPs, has anticancer effects on colorectal cancer. The present study investigated the anticancer effects and potential mechanisms of BSGLWE on colorectal cancer in vivo and in vitro. Our results showed that BSGLWE significantly inhibited colorectal cancer HCT116 cell viability in a time- and dose-dependent manner. Flow cytometry analysis indicated that BSGLWE disrupted cell cycle progression at G2/M phase via downregulation of cyclin B1 and cyclin A2, and upregulation of P21 at mRNA levels. Moreover, BSGLWE induced apoptosis by decreasing Bcl-2 and survivin at mRNA levels, and reduced Bcl-2, PARP, pro-caspase-3 and pro-caspase-9 at protein levels. Furthermore, BSGLWE suppressed tumor growth in vivo by regulating the expression of genes and proteins associated with cell cycle and apoptosis, which was further confirmed by a reduction of Ki67, PCNA, and Bcl-2 expression as determined by immunohistochemistry staining. NSAID activated gene-1 (NAG-1), a pro-apoptotic gene, was significantly upregulated in vivo and in vitro upon BSGLWE treatment at both mRNA and protein levels. In addition, the relative amounts of secreted NAG-1 in cell culture medium or serum of nude mice were all upregulated upon BSGLWE treatments, suggesting a role of NAG-1 in BSGLWE-induced anticolorectal cancer activity. This is the first study to show that BSGLWE inhibits colorectal cancer carcinogenesis through regulating genes responsible for cell proliferation, cell cycle and apoptosis cascades. These findings indicate that BSGLWE possesses chemopreventive potential in colorectal cancer which may serve as a promising anticancer agent for clinical applications.

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Section: Discussionmentioning

confidence: 99%

Anticarcinogenic effects of water extract of sporoderm-broken spores of Ganoderma lucidum on colorectal cancer in vitro and in vivo

Sang

et al. 2017

International Journal of Oncology

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“…As a result, a systematic review evaluates the clinical effects of G. lucidum on long-term survival, tumor response, host immune functions, and quality of life in cancer patients, as well as adverse events associated with its use. The study concluded that incorporation of G. lucidum treatment can improve tumor response of lung cancer to conventional therapy and may enhance immunity by stimulating T-lymphocyte proliferation, suggesting that it is a promising adjunct to counter the unwanted common immunosuppressive effect of many chemotherapeutic drugs [41]. As mentioned in WHO's report, new drugs not necessarily eradicate tumors but, when combined with other agents, may turn cases of fatal cancer into manageable chronic illness.…”

Section: Clinical Studies With Humansmentioning

confidence: 99%

Medicinal mushrooms in adjuvant cancer therapies: an approach to anticancer effects and presumed mechanisms of action

Figueiredo

Régis

2017

Nutrire

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Mushrooms have been used for centuries as a source of nourishment and sensory properties. Mushrooms are considered functional foods due to their bioactive compounds and a source of drug and nutraceutical development. More than 50 species present immunological potential that exhibit anticancer activity in vitro or in animal models, and some of them have been investigated in human cancers. Cancer is a major cause of death all over the world, promoting long lasting effects throughout the lifetime of the patient. Mushrooms are a source of ergothioneine, selenium, fiber, and several other vitamins and minerals. They have bioactive compounds used in cancer treatment due to their antitumor and anticarcinogenic effects. They contain β-glucans, β-proteoglycans, lectins, triterpenes, ergosterol, glutamine, and arginine. In the present study, we perform a literature review of studies that analyze positive impacts of mushroom compounds on cancer treatment due to their antitumor and anticarcinogenic effects and possible compatibility with chemotherapy management. The review indicates that a healthy diet with frequent consumption of mushrooms apparently reduces the risk of developing cancer. However, a clearer understanding of how mushrooms' bioactive principles may affect adjuvant treatments requires further research with long-term double-blind and placebo-controlled studies that evaluate a larger population in clinical trials by each type of cancer. Therefore, more robust statistical results are necessary to verify their efficacy and safety on cancer treatments.

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“…A systematic review determining the effectiveness of Lingzhi in treating risk factors of cardiovascular diseases concluded that current evidence is inadequate to support the efficacy of Lingzhi, and the quality of the studies was poor 9 . Another systematic review evaluating the clinical efficacy of Lingzhi found that available evidence was insufficient to justify using Lingzhi for cancer treatment 10 . Therefore, more well‐planned clinical studies are needed to determine the efficacy of Lingzhi regarding all proposed health benefits.…”

Section: Lingzhimentioning

confidence: 99%

Lingzhi and Cordyceps

Sum

Ziegler

2016

Nut in Clin Prac

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Ganoderma lucidum (Reishi mushroom) for cancer treatment

Abstract: ects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients. Immunological

Cited by 101 publications

References 30 publications

Anticarcinogenic effects of water extract of sporoderm-broken spores of Ganoderma lucidum on colorectal cancer in vitro and in vivo

Anticarcinogenic effects of water extract of sporoderm-broken spores of Ganoderma lucidum on colorectal cancer in vitro and in vivo

Medicinal mushrooms in adjuvant cancer therapies: an approach to anticancer effects and presumed mechanisms of action

Lingzhi and Cordyceps

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