<i>Ganoderma lucidum</i> polysaccharide inhibits UVB‐induced melanogenesis by antagonizing cAMP/PKA and ROS/MAPK signaling pathways

Hu, Shuanghai; Huang, Jinhua; Pei, Shiyao; Ouyang, Yujie; Ding, Yufang; Jiang, Ling; Lu, Jianyun; Kang, Liyang; Huang, Lihua; Xiang, Hong; Xiao, Rong; Zeng, Qinghai; Chen, Jing

doi:10.1002/jcp.27492

Cited by 81 publications

(54 citation statements)

References 44 publications

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“…UV radiation is the most important external cause of melanogenesis (Glady et al, 2018;Mishima and Tanay, 1968). Current studies have found that UV light can promote melanogenesis through epigenetic modifications (Zhang et al, 2019), DNA damage repair (Kemp et al, 2019;Oonincx et al, 2018), signal transduction (Hu et al, 2019), and the alteration of the MC microenvironment (Glady et al, 2018;Pei et al, 2018). It is well known that any biological behavior exerts positive and negative feedback to maintain homeostasis.…”

Section: Discussionmentioning

confidence: 99%

The Long Noncoding RNA UCA1 Negatively Regulates Melanogenesis in Melanocytes

Pei

Chen

et al. 2020

Journal of Investigative Dermatology

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The long noncoding RNA UCA1 was first discovered in bladder cancer and is known to regulate the proliferation and migration of melanoma. However, its role in melanogenesis is unclear. In this study, we aimed to explore the role and mechanism of UCA1 in melanogenesis. Our findings showed that the expression of UCA1 was negatively correlated with melanin content in melanocytes and pigmented nevus. Overexpression of UCA1 in melanocytes decreased melanin content and the expression of melanogenesis-related genes, whereas knockdown of UCA1 in melanocytes had the opposite effect. High-throughput sequencing revealed that microphthalmia-associated transcription factor (MITF), an important transcription factor affecting melanogenesis, was also negatively correlated with the expression of UCA1. Furthermore, the transcription factor CRE-binding protein (CREB), which promotes MITF expression, was negatively regulated by UCA1. The cAMP/ protein kinase A (PKA), extracellular signaleregulated kinase (ERK), and c-Jun N-terminal kinase (JNK) signaling pathways, which are upstream of the CREB/MITF/melanogenesis axis, were activated or inhibited in response to silencing or enhancing UCA1 expression, respectively. In addition, enhanced UCA1 expression downregulates the expression of melanogenesis-related genes induced by UVB in melanocytes. In conclusion, UCA1 may negatively regulate the CREB/MITF/melanogenesis axis through inhibiting the cAMP/PKA, ERK, and JNK signaling pathways in melanocytes. UCA1 may be a potential therapeutic target for the treatment of pigmented skin diseases.

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Section: Discussionmentioning

confidence: 99%

The Long Noncoding RNA UCA1 Negatively Regulates Melanogenesis in Melanocytes

Pei

Chen

et al. 2020

Journal of Investigative Dermatology

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“…Although most studies indicate that melatonin exhibits antioxidant properties, there are increasing evidences in cancer cells that the indoleamine displays pro-oxidant activity [28] and that the reactive oxygen species (ROS) could play a role in the regulation of melanogenesis in melanoma cells [20,29,30]. To determine whether melatonin stimulates reactive oxygen species production in SK-MEL-1, treated cells were incubated for different time periods and intracellular levels of these chemical species were analyzed by flow cytometry using the H 2 -DCF fluorescent probe.…”

Section: Reactive Oxygen Species Are Involved In the Stimulatory Effementioning

confidence: 99%

Melatonin Induces Melanogenesis in Human SK-MEL-1 Melanoma Cells Involving Glycogen Synthase Kinase-3 and Reactive Oxygen Species

Perdomo

Quintana

González

et al. 2020

IJMS

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Melatonin is present in all living organisms where it displays a diversity of physiological functions. Attenuation of melanogenesis by melatonin has been reported in some mammals and also in rodent melanoma cells. However, melatonin may also stimulate melanogenesis in human melanoma cells through mechanisms that have not yet been revealed. Using the human melanoma cells SK-MEL-1 as a model, an increase in both tyrosinase activity and melanin was already observed at 24 h after melatonin treatment with maximal levels of both being detected at 72 h. This effect was associated with the induction in the expression of the enzymes involved in the synthesis of melanin. In this scenario, glycogen synthase kinase-3β seems to play a significant function since melatonin decreased its phosphorylation and preincubation with specific inhibitors of this protein kinase (lithium or BIO) reduced the expression and activity of tyrosinase. Blocking of PI3K/AKT pathway stimulated melanogenesis and the effect was suppressed by the inhibitors of glycogen synthase kinase-3β. Although melatonin is a recognized antioxidant, we found that it stimulates reactive oxygen species generation in SK-MEL-1 cells. These chemical species seem to be an important signal in activating the melanogenic process since the antioxidants N-acetyl-l-cysteine and glutathione decreased both the level and activity of tyrosinase stimulated by melatonin. Our results support the view that regulation of melanogenesis involves a cross-talk between several signaling pathways.

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“…Ubtan (UF-1 to UF-4) rhizome of Curcuma longa L. seeds of Cicer arietinum L. heartwood of Santalum album L. With the ratio of 2:2:2 (UF-1), 1:2:2 (UF-2), 2:1:2 (UF-3) and 2:2:1 (UF-4) antioxidant; sun protection; suppressing tyrosinase activity in vitro: mushroom tyrosinase (Hu et al, 2019;Jiang et al, 2019). Goji berry (Lycium chinense Mill.)…”

Section: Herbal Extractsmentioning

confidence: 99%

Traditional Asian Herbs in Skin Whitening: The Current Development and Limitations

Zeng

Huang

et al. 2020

Front. Pharmacol.

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In Asia, the market for whitening cosmetics is expanding rapidly, more and more people prefer to use natural products. Driven by natural product demand and technical advances, herbal research is also developing fast. Lots of studies reported that Asian herbal reagents can reduce melanogenesis, these findings provide evidence for the whitening application of Asian herbs. However, the current development status and challenges of herbal research need attention too. By reviewing these studies, different problems in studying herbal formulas, extracts, and active ingredients were presented. One of the most influential troubles is that the components of herbs are too complex to obtain reliable results. Thus, an understanding of the overall quality of herbal research is necessary. Further, 90 most cited Asian herbal studies on whitening were collected, which were conducted between 2017 and 2020, then statistical analysis was carried out. This work provided a comprehensive understanding of Asian herbal research in skin whitening, including the overall status and quality, as well as the focuses and limitations of these studies. By proactively confronting and analyzing these issues, it is suggested that the focus of herbal medicine research needs to shift from quantity to quality, and the new stage of development should emphasize transformation from research findings to whitening products.

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Ganoderma lucidum polysaccharide inhibits UVB‐induced melanogenesis by antagonizing cAMP/PKA and ROS/MAPK signaling pathways

Cited by 81 publications

References 44 publications

The Long Noncoding RNA UCA1 Negatively Regulates Melanogenesis in Melanocytes

The Long Noncoding RNA UCA1 Negatively Regulates Melanogenesis in Melanocytes

Melatonin Induces Melanogenesis in Human SK-MEL-1 Melanoma Cells Involving Glycogen Synthase Kinase-3 and Reactive Oxygen Species

Traditional Asian Herbs in Skin Whitening: The Current Development and Limitations

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