Fusobacterium nucleatum
promotes inflammatory and anti-apoptotic responses in colorectal cancer cells via ADP-heptose release and ALPK1/TIFA axis activation
Camille Martin-Gallausiaux,
Laurène Salesse,
Diego Garcia-Weber
et al.
Abstract:The anaerobic bacterium
Fusobacterium nucleatum
is significantly associated with human colorectal cancer (CRC) and is considered a significant contributor to the disease. The mechanisms underlying the promotion of intestinal tumor formation by
F. nucleatum
have only been partially uncovered. Here, we showed that
F. nucleatum
releases a metabolite into the microenvironment that strongly activates NF-κB in intestinal epithelial cells via the AL… Show more
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