<i>Fusarium solani</i>haplotype 12‐b and aortic and branchial arteritis in<i>Hippocampus erectus</i>Perry

Brown, Tori; Millar, Zach; Evans, D. Ieuan; Pham, Phuc H.; LePage, Véronique; Lumsden, John S.

doi:10.1111/jfd.13099

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…Infectious agents may be the most significant cause of high morbidity and mortality and are often problematic because of inadequate rearing conditions (Lin et al., 2009) and improper diets (Yin et al., 2012). These infectious agents can include ciliated protozoa (Chen et al., 2019), fungi (Brown et al., 2019) and bacteria (Qin et al., 2017). Bacterial infections are a common health regard in captive‐bred seahorses, including those from Vibrio species (Tendencia, 2004).…”

Section: Figurementioning

confidence: 99%

Lipoid liver disease in Hippocampus erectus Perry with Vibrio fortis‐induced dermatitis and enteritis

Evans

Millar

Harding

et al. 2022

Journal of Fish Diseases

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Section: Figurementioning

confidence: 99%

Lipoid liver disease in Hippocampus erectus Perry with Vibrio fortis‐induced dermatitis and enteritis

Evans

Millar

Harding

et al. 2022

Journal of Fish Diseases

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“…The genus, commonly identified as plant pathogens, has caused devastating losses in the global agricultural industry [3] and is recognised as one of the most prevalent clinical pathogens causing superficial and invasive disease in immunocompromised humans [4,5]. In recent decades, an increasing number of fusariosis cases associated with various types of animals have been reported worldwide [6][7][8][9][10], but research on the virulence of pathogens causing fusariosis beyond plant hosts remains limited [11,12]. The disease is now considered to be a serious emerging fungal threat potentially inducing host population loss and extinction [2,13].…”

Section: Introductionmentioning

confidence: 99%

Comparative genomic and transcriptomic analyses of trans-kingdom pathogen Fusarium solani species complex reveal degrees of compartmentalization

et al. 2022

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Background The Fusarium solani species complex (FSSC) comprises fungal pathogens responsible for mortality in a diverse range of animals and plants, but their genome diversity and transcriptome responses in animal pathogenicity remain to be elucidated. We sequenced, assembled and annotated six chromosome-level FSSC clade 3 genomes of aquatic animal and plant host origins. We established a pathosystem and investigated the expression data of F. falciforme and F. keratoplasticum in Chinese softshell turtle (Pelodiscus sinensis) host. Results Comparative analyses between the FSSC genomes revealed a spectrum of conservation patterns in chromosomes categorised into three compartments: core, fast-core (FC), and lineage-specific (LS). LS chromosomes contribute to variations in genomes size, with up to 42.2% of variations between F. vanettenii strains. Each chromosome compartment varied in structural architectures, with FC and LS chromosomes contain higher proportions of repetitive elements with genes enriched in functions related to pathogenicity and niche expansion. We identified differences in both selection in the coding sequences and DNA methylation levels between genome features and chromosome compartments which suggest a multi-speed evolution that can be traced back to the last common ancestor of Fusarium. We further demonstrated that F. falciforme and F. keratoplasticum are opportunistic pathogens by inoculating P. sinensis eggs and identified differentially expressed genes also associated with plant pathogenicity. These included the most upregulated genes encoding the CFEM (Common in Fungal Extracellular Membrane) domain. Conclusions The high-quality genome assemblies provided new insights into the evolution of FSSC chromosomes, which also serve as a resource for studies of fungal genome evolution and pathogenesis. This study also establishes an animal model for fungal pathogens of trans-kingdom hosts.

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“…The genus, commonly identified as plant pathogens, has caused devastating losses in the global agricultural industry (Dean et al, 2012) and is recognized as one of the most prevalent clinical pathogens causing superficial and invasive disease in immunocompromised humans (Al-Hatmi et al, 2016; Walther et al, 2017). In recent decades, an increasing number of fusariosis cases associated with various types of animals have been reported worldwide (Brown et al, 2020; Cabañes et al, 1997; Fernando et al, 2015; Hsu et al, 2021; Kano et al, 2002), but research on its virulence beyond plant hosts remains limited (Coleman, 2016; Rep & Kistler, 2010). It is now considered as a serious emerging fungal threat potentially inducing host population loss and extinction (Fisher et al, 2012; O’Donnell et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Fusarium solanispecies complex genomes reveal bases of compartmentalisation and animal pathogenesis

Hoh

Lee

Wada

et al. 2022

Preprint

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The Fusarium solani species complex (FSSC) comprises fungal pathogens responsible for mortality in a diverse range of animals and plants, but their genome diversity and transcriptome responses in animal pathogenicity remain to be elucidated. We sequenced and compared six chromosome-level FSSC clade 3 genomes of aquatic animal and plant host origins and revealed a spectrum of conservation patterns in chromosomes categorised into three compartments: core, fast-core (FC), and lineage-specific (LS). Each chromosome type varied in structural architectures, with FC and LS chromosomes containing significantly higher proportions of repetitive elements and methylation levels than core chromosomes, with genes exhibiting higher dN/dS and enriched in functions related to pathogenicity and niche expansion. Mesosynteny were detected between FC chromosomes of Fusarium genomes, indicating that these chromosomes were present in a common ancestor that predated FSSC species. These findings provide evidence that genome compartmentalisation was the outcome of multi-speed evolution amongst FSSC chromosomes. We further demonstrated that F. falciforme and F. keratoplasticum are opportunistic pathogens by inoculating Pelodiscus sinensis eggs and identified differentially expressed genes also associated with plant pathogenicity. These included the most upregulated genes encoding the CFEM (Common in Fungal Extracellular Membrane) domain. The study establishes genomic resources and an animal model for fungal pathogens of trans-kingdom hosts.

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Fusarium solanihaplotype 12‐b and aortic and branchial arteritis inHippocampus erectusPerry

Cited by 4 publications

References 17 publications

Lipoid liver disease in Hippocampus erectus Perry with Vibrio fortis‐induced dermatitis and enteritis

Lipoid liver disease in Hippocampus erectus Perry with Vibrio fortis‐induced dermatitis and enteritis

Comparative genomic and transcriptomic analyses of trans-kingdom pathogen Fusarium solani species complex reveal degrees of compartmentalization

Fusarium solanispecies complex genomes reveal bases of compartmentalisation and animal pathogenesis

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