<i>Fusarium</i>spp.—An Emerging Pathogen in Chronic Diabetic Ulcer: Case Report and Review of the Literature

João, Ana Luísa; Lencastre, André; Dutra, Eduardo; Costa, Tomás Pessoa e; Formiga, Ana; Neves, José

doi:10.1177/1534734619879030

Cited by 6 publications

(3 citation statements)

References 20 publications

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“…Two very interesting case reports 8,9 and other very useful contributions enrich the present issue. And the theme is set for 2021: the journal will continue pursuing progress in wound healing.…”

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confidence: 61%

Sweet Readers Love the Spring

Παπάνας

Papi²

2021

The International Journal of Lower Extremity Wounds

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This is the first 2021 issue. Please enjoy the journal's new front cover. But please also cherish the scientific content, rich and variegated, indeed. Thanganadar Appapalam and colleagues 1 have revisited multi-drug resistant bacteria in diabetic foot ulcers. In a similar context, Körpinar 2 has carried out a retrospective enquiry into bacterial isolates of diabetic foot infections in end-stage renal disease. Pincelli and colleagues 3 describe the clinical picture and hallmarks of Livedo racemosa. Three further works explore innovations in chronic wound healing. 4-6 In rats, Bilgic 7 has studied the efficacy of local and systemic resveratrol in wound healing. Two very interesting case reports 8,9 and other very useful contributions enrich the present issue. And the theme is set for 2021: the journal will continue pursuing progress in wound healing. 10,11 It will also publish some new educational articles, as in the past. 12 Meanwhile, this issue of young 2021 is to be treasured, like tender spring around us. 13 Declaration of Conflicting Interests The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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confidence: 61%

Sweet Readers Love the Spring

Παπάνας

Papi²

2021

The International Journal of Lower Extremity Wounds

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“…Amphotericin B, natamycin and newer azoles such as voriconazole are recommended as the most active antifungal agents for Fusarium foot osteomyelitis. Although treatment guidelines do not include this therapy, oral voriconazole is an adequate empirical treatment for Fusarium foot osteomyelitis before required susceptibility tests ( João, et al, 2021 ). Aspergillus conidia is a ubiquitous commensal fungi in the respiratory tract; however, Aspergillus infections in chronic wounds are rare.…”

Section: Fungi In Chronic Woundsmentioning

confidence: 99%

Current research on fungi in chronic wounds

Wang

2023

Front. Mol. Biosci.

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The occurrence of chronic wounds is a major global health issue. These wounds are difficult to heal as a result of disordered healing mechanisms. The most common types of chronic wounds are diabetic ulcers, pressure ulcers, arterial/venous ulcers and nonhealing surgical wounds. Although bacteria are an important cause of chronic nonhealing wounds, fungi also play a substantial role in them. The fungal infection rate varies with different chronic wound types, but overall, the prevalence of fungi is extremely underestimated in the clinical treatment and management of chronic wounds. Wounds and ulcers can be colonized by host cutaneous, commensal or environmental fungi and evolve into local infections, causing fungemia as well as invasive fungal disease. Furthermore, the fungi involved in nonhealing wound-related infections help commensal bacteria resist antibiotics and the host immune response, forcing wounds to become reservoirs for multiresistant species, which are considered a potential key factor in the microbial bioburden of wounds and ulcers. Fungi can be recalcitrant to the healing process. Biofilm establishment is the predominant mechanism of fungal resistance or tolerance to antimicrobials in chronic nonhealing wounds. Candida albicans yeast and Trichophyton rubrum filamentous fungi are the main fungi involved in chronic wound infection. Fungal species diversity and drug resistance phenotypes in different chronic nonhealing wound types will be emphasized. In this review, we outline the latest research on fungi in chronic wounds and discuss challenges and future perspectives related to diagnosing and managing chronic wounds.

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“…Fusarium-related diseases have a substantial economic impact on a wide range of crops, including fruits, vegetables, cereals, and cellulose production [3,6,7]. In humans, Fusarium oxysporum is an opportunistic pathogen, responsible for conditions such as keratitis, onychomycosis, and invasive infections in both immunocompromised and immunocompetent individuals [4,8,9].…”

Section: Introductionmentioning

confidence: 99%

Light-Driven Tetra- and Octa-β-substituted Cationic Zinc(II) Phthalocyanines for Eradicating Fusarium oxysporum Conidia

Lourenço,

Cunha,

Sierra-Garcia

2023

IJMS

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Photodynamic inactivation (PDI) is an emerging therapeutic approach that can effectively inactivate diverse microbial forms, including vegetative forms and spores, while preserving host tissues and avoiding the development of resistance to the photosensitization procedure. This study evaluates the antifungal and sporicidal photodynamic activity of two water-soluble amphiphilic tetra- and octa-β-substituted zinc(II) phthalocyanine (ZnPc) dyes with dimethylaminopyridinium groups at the periphery (ZnPcs 1, 2) and their quaternized derivatives (ZnPcs 1a, 2a). Tetra(1, 1a)- and octa(2, 2a)-β-substituted zinc(II) phthalocyanines were prepared and assessed as photosensitizers (PSs) for their effects on Fusarium oxysporum conidia. Antimicrobial photoinactivation experiments were performed with each PS at 0.1, 1, 10, and 20 µM under white light irradiation at an irradiance of 135 mW·cm–2, for 60 min (light dose of 486 J·cm−2). High PDI efficiency was observed for PSs 1a, 2, and 2a (10 µM), corresponding to inactivation until the method’s detection limit. PS 1 (20 µM) also achieved a considerable reduction of >5 log10 in the concentration of viable conidia. The quaternized PSs (1a, 2a) showed better PDI performance than the non-quaternized ones (1, 2), even at the low concentration of 1 µM, and a light dose of 486 J·cm−2. These cationic phthalocyanines are potent photodynamic drugs for antifungal applications due to their ability to effectively inactivate resistant forms, like conidia, with low concentrations and reasonable energy doses.

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Fusariumspp.—An Emerging Pathogen in Chronic Diabetic Ulcer: Case Report and Review of the Literature

Cited by 6 publications

References 20 publications

Sweet Readers Love the Spring

Sweet Readers Love the Spring

Current research on fungi in chronic wounds

Light-Driven Tetra- and Octa-β-substituted Cationic Zinc(II) Phthalocyanines for Eradicating Fusarium oxysporum Conidia

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