<i>Fusarium</i>: a treasure trove of bioactive secondary metabolites

Li, Mingzhu; Yu, Ronglu; X, Bai; Wang, Hong; Zhang, Huawei

doi:10.1039/d0np00038h

Cited by 52 publications

(39 citation statements)

References 139 publications

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“…No obstante, Azil et al (2021) reporta ocho aislamientos identificados como F. equiseti en tubérculos de Solanum tuberosum con síntomas de podredumbre seca en las regiones de Argelia, presentando micotoxinas como tricotecenos y zearalenona, las cuales presentan una alta toxicidad. Las especies del Fusarium se han descrito como hongos filamentosos ocasionales, incluidos como patógenos oportunistas infectando diverso tipo de plantas en todo el mundo, pero a su vez pueden crecer como saprofitos en un rango de zonas climáticas (Stępień et al, 2020) y presenta una producción de metabolitos secundarios tóxicos, que son motivo de preocupación para la salud humana y animal (Li et al, 2020). Las especies de Fusarium pueden causar la infección de las partes subterráneas del tubérculo de ñame desde etapas muy tempranas, presentado una alta especificidad por las variedades de pulpa blanca y ocasionando el 68.4 % de las infecciones en los tubérculos.…”

Section: Discussionunclassified

Capacidad de infección de hongos asociados a la pudrición seca de los Tubérculos de Ñame

López

Castellanos

Espinosa-Carvajal

et al. 2021

Rev. Investig. Altoandin.

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Dry rot of tubers is one of the most devastating diseases in yam production (Dioscorea rotundata Poir.) in the Caribbean region of Colombia. The disease attacks tubers, causing production losses during cultivation. In previous experiments, 11 fungal morphotypes were isolated and associated with this disease in yam crops in the Caribbean region of Colombia. The present investigation was carried out under greenhouse conditions to determine the infection capacity of these 11 possible causative agents, in 150-day-old plants of two yam genetic materials (0307-49SB y 0307-50CB). The results indicated that morphotypes DH2 (Lasiodiplodia theobromae), DH11 (Curvularia aeria), DH20 (Aspergillus niger), and DH17 (Fusarium equiseti), showed the highest infection capacity to yam tubers, regardless of the genetic material. Therefore, they were considered as the main causal agents of the disease in the Caribbean region of Colombia. The remaining seven (7) morphotypes, despite having been inoculated in the roots of the plants, showed minor effects on tubers and affected other organs of the plant, especially stems and aerial part of yam plant. This study allows concentrating the research on these four morphotypes to develop crop management strategies that might allow reducing the incidence of this disease in the Caribbean region of Colombia.

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Section: Discussionunclassified

Capacidad de infección de hongos asociados a la pudrición seca de los Tubérculos de Ñame

López

Castellanos

Espinosa-Carvajal

et al. 2021

Rev. Investig. Altoandin.

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“…and Xylariaceae strains, 53,59 it was possible to identify new compounds in these two species by using OSMAC method, i.e. confrontation between phytopathogenic and endophytic strain in our case.…”

Section: Focic Bsnb-0294mentioning

confidence: 96%

Identification of Antagonistic Compounds between the Palm Tree Xylariale Endophytic Fungi and the Phytopathogen Fusarium oxysporum

Barthélemy

Elie

Genta‐Jouve

et al. 2021

J. Agric. Food Chem.

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To discover microorganisms that naturally possess chemical weapons against the phytopathogen Fusarium oxysporum, the biological and chemical diversity of plant leaf endophytes was investigated. Endophytes were isolated from the palm tree Astrocaryum sciophyllum collected in pristine forests of French Guiana. Several Xylariaceae inhibited the growth of F. oxysporum and were further explored. Antifungal specialized metabolites were isolated from the Xylariaceae BSNB-0294 strain in confrontation with phytopathogen and led to the identification of undescribed compounds, i.e., two depsipeptides named xylariaceins, two metabolites containing a 3-imidazolinone moiety, and four new compounds including a nitrophenylpropanamide and three phenylalanine analogs named xylariains A-D. In parallel, chemical investigation of the phytopathogen during the coculture led to the identification of an unknown compound, which we named focicin. The production of focicin was exacerbated during the competition. MALDI-TOF MS imaging of the competition between BSNB-0294 (endophytic strain) and F. oxysporum f.sp. ciceris (phytopathogen) highlighted time-dependent chemical interactions between the two microorganisms.

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“…The production of secondary metabolites by fungi represents a vast field of research whose interest continues to grow, as evidenced by the large number of publications on the subject that appear every year. The chemical variety of secondary metabolites is impressive (see, e.g., [119,120]), of which this entry mentions only a few representative examples. The large number of investigated SM clusters, many of them with biochemical knowledge of the encoded enzymes, and the increasing number of fungal genomes whose sequences are available in the databases, have allowed an explosion of genetic mining work in many fungi [4,121].…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

Fungal Secondary Metabolism

Ávalos

Limón

2021

Encyclopedia

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Fungal secondary metabolites (SMs) comprise a vast collection of compounds expendable for these organisms under laboratory conditions. They exhibit enormous chemical diversity, and usually belong to four major families: terpenoids, polyketides, non-ribosomal peptides, or a combination of the last two. Their functions are very diverse and are normally associated with a greater fitness of the producing fungi in their environment, which often compete with other microorganisms or interact with host plants. Many SMs have beneficial applications, e.g., as antibiotics or medical drugs, but others, known as mycotoxins, are harmful to health.

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Fusarium: a treasure trove of bioactive secondary metabolites

Abstract: Fusarium, one of the most common fungal genera, has received considerable attention because of its biosynthetic exuberance, the result of many unique gene clusters involved in the production of secondary metabolites.

Cited by 52 publications

References 139 publications

Capacidad de infección de hongos asociados a la pudrición seca de los Tubérculos de Ñame

Capacidad de infección de hongos asociados a la pudrición seca de los Tubérculos de Ñame

Identification of Antagonistic Compounds between the Palm Tree Xylariale Endophytic Fungi and the Phytopathogen Fusarium oxysporum

Fungal Secondary Metabolism

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