Foxg1 bimodally tunes L1-mRNA and -DNA dynamics in the developing murine neocortex
Gabriele Liuzzi,
Osvaldo Artimagnella,
Simone Frisari
et al.
Abstract:Foxg1 masters telencephalic development via a pleiotropic control over its progression. Expressed within the central nervous system (CNS), L1 retrotransposons are implicated in progression of its histogenesis and tuning of its genomic plasticity. Foxg1 represses gene transcription, and L1 elements share putative Foxg1 binding motifs, suggesting the former might limit telencephalic expression (and activity) of the latter. We tested such prediction, in vivo as well as in engineered primary neural cultures, by lo… Show more
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