<i>Flos magnoliae</i> constituent fargesin has an anti-allergic effect <i>via</i> ORAI1 channel inhibition

Hong, Phan Thi Lam; Kim, Hyun Jong; Kim, Woo Kyung; Nam, Joo Hyun

doi:10.4196/kjpp.2021.25.3.251

Cited by 15 publications

(8 citation statements)

References 49 publications

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“…HEK293T, RBL-2H3, Jurkat T-cells, and a cell line overexpressing KCa3.1 were obtained from ATCC (Manassas, VA, USA). All cells were cultured according to a previously described method [ 42 , 43 ]. In brief, the HEK293T and KCa3.1-overexpressing cell lines were maintained in DMEM (Welgene, Gyeongsan, Korea), whereas the Jurkat T-cells were maintained in RPMI1640 (Thermo Fisher Scientific, Waltham, MA, USA); these media were supplemented with a final concentration of 10% FBS (Welgene, Gyeongsan, Korea) and 1% penicillin/streptomycin (Hyclone, Marlborough, MA, USA).…”

Section: Methodsmentioning

confidence: 99%

Anti-Inflammatory Effect of Licochalcone A via Regulation of ORAI1 and K+ Channels in T-Lymphocytes

Hong

Kim

et al. 2021

IJMS

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Calcium signaling plays a vital role in the regulation of various cellular processes, including activation, proliferation, and differentiation of T-lymphocytes, which is mediated by ORAI1 and potassium (K+) channels. These channels have also been identified as highly attractive therapeutic targets for immune-related diseases. Licochalcone A is a licorice-derived chalconoid known for its multifaceted beneficial effects in pharmacological treatments, including its anti-inflammatory, anti-asthmatic, antioxidant, antimicrobial, and antitumorigenic properties. However, its anti-inflammatory effects involving ion channels in lymphocytes remain unclear. Thus, the present study aimed to investigate whether licochalcone A inhibits ORAI1 and K+ channels in T-lymphocytes. Our results indicated that licochalcone A suppressed all three channels (ORAI1, Kv1.3, and KCa3.1) in a concentration-dependent matter, with IC50 values of 2.97 ± 1.217 µM, 0.83 ± 1.222 µM, and 11.21 ± 1.07 µM, respectively. Of note, licochalcone A exerted its suppressive effects on the IL-2 secretion and proliferation in CD3 and CD28 antibody-induced T-cells. These results indicate that the use of licochalcone A may provide an effective treatment strategy for inflammation-related immune diseases.

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Section: Methodsmentioning

confidence: 99%

Anti-Inflammatory Effect of Licochalcone A via Regulation of ORAI1 and K+ Channels in T-Lymphocytes

Hong

Kim

et al. 2021

IJMS

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“…Indeed, ORAI1 expression in nuocytes has been implicated in the exacerbated response to IL‐33 in those mice 99 . Following this line, there is preliminary evidence that compounds disrupting ORAI1 signalization alleviate NHR symptoms in murine allergic rhinitis models, such as aminoethoxydiphenyl borate (2‐APB), natural compounds extracted from Flos magnoliae (through fargesin and other active principles), anti‐ORAI1 antibodies and short hairpin RNA, opening a promising research direction to develop new treatments 98,100–102 …”

Section: Epithelial and Somatosensory Pathophysiology In Nhrmentioning

confidence: 99%

Epithelial and sensory mechanisms of nasal hyperreactivity

Velasco

Delicado‐Miralles²,

Hellings

et al. 2022

Allergy

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“…Fargesin is a type of lignan with pharmacological activity and is extracted from Flos magnoliae (FM), which has long been used in the treatment of emphysema, sinusitis and headaches. It is reported that FM extracts have significant anti-allergic and anti-inflammatory effects ( 47 ). Recent studies have found that fargesin is critical for inflammatory response and glucose metabolism ( 48 ).…”

Section: Macrophages Are Emerging Targets For Oa Treatmentmentioning

confidence: 99%

Role of macrophage polarization in osteoarthritis (Review)

Chen

Hong

Sun³

et al. 2022

Exp Ther Med

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Osteoarthritis (OA) is a disease involving the whole joint that seriously reduces the living standards of individuals. Traditional treatments include physical therapy, administration of anti-inflammatory and analgesic drugs and injection of glucocorticoids or hyaluronic acid into the joints. However, these methods have limited efficacy and it is difficult to reverse the progression of OA, therefore it is urgent to find new effective treatment methods. Immune microenvironment is significant in the occurrence and development of OA. Recent studies have shown that macrophages are important targets for the treatment of OA. Macrophages are polarized into M1 pro-inflammatory phenotype and M2 anti-inflammatory phenotype under stimulation of different factors, which release and regulate inflammatory response and cartilage growth. Accumulating studies have tried to alleviate OA by regulating macrophage homeostasis. The present study summarized the related studies, discuss the mechanism of various therapeutic reagents on OA, expound the molecular mechanism of drug effect on OA and attempted to provide clues for the treatment of OA.

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Flos magnoliae constituent fargesin has an anti-allergic effect via ORAI1 channel inhibition

Cited by 15 publications

References 49 publications

Anti-Inflammatory Effect of Licochalcone A via Regulation of ORAI1 and K+ Channels in T-Lymphocytes

Anti-Inflammatory Effect of Licochalcone A via Regulation of ORAI1 and K+ Channels in T-Lymphocytes

Epithelial and sensory mechanisms of nasal hyperreactivity

Role of macrophage polarization in osteoarthritis (Review)

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