<i>Ficus carica</i>polysaccharide attenuates DSS-induced ulcerative colitis in C57BL/6 mice

Zou, Qianhui; Zhang, Xin; Liu, Xiaoshuang; Li, Yitong; Tan, Qiaoli; Qin, Dan; Tian, Yuan; Liu, Xuebo; Liu, Rui Hai; Liu, Zhigang

doi:10.1039/d0fo01162b

Cited by 72 publications

(46 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During the last twenty years, multiple publications identified a changed composition and metabolism of the gut microbiota associated with increased SCFA concentrations as a possible anti-inflammatory mechanism [ 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 ]. In contrast, high-sugar diet was shown to enhance susceptibility to DSS-colitis via depletion of luminal short chain fatty acids [ 181 ].…”

Section: Short Chain Fatty Acidsmentioning

confidence: 99%

Role of Short Chain Fatty Acids and Apolipoproteins in the Regulation of Eosinophilia-Associated Diseases

Sturm

Knuplez

Marsche

2021

IJMS

View full text Add to dashboard Cite

Eosinophils are key components of our host defense and potent effectors in allergic and inflammatory diseases. Once recruited to the inflammatory site, eosinophils release their cytotoxic granule proteins as well as cytokines and lipid mediators, contributing to parasite clearance but also to exacerbation of inflammation and tissue damage. However, eosinophils have recently been shown to play an important homeostatic role in different tissues under steady state. Despite the tremendous progress in the treatment of eosinophilic disorders with the implementation of biologics, there is an unmet need for novel therapies that specifically target the cytotoxic effector functions of eosinophils without completely depleting this multifunctional immune cell type. Recent studies have uncovered several endogenous molecules that decrease eosinophil migration and activation. These include short chain fatty acids (SCFAs) such as butyrate, which are produced in large quantities in the gastrointestinal tract by commensal bacteria and enter the systemic circulation. In addition, high-density lipoprotein-associated anti-inflammatory apolipoproteins have recently been shown to attenuate eosinophil migration and activation. Here, we focus on the anti-pathogenic properties of SCFAs and apolipoproteins on eosinophil effector function and provide insights into the potential use of SCFAs and apolipoproteins (and their mimetics) as effective agents to combat eosinophilic inflammation.

show abstract

Section: Short Chain Fatty Acidsmentioning

confidence: 99%

Role of Short Chain Fatty Acids and Apolipoproteins in the Regulation of Eosinophilia-Associated Diseases

Sturm

Knuplez

Marsche

2021

IJMS

View full text Add to dashboard Cite

show abstract

“…The mucosal biopsy of IBD patients and the acetic acid-induced rat colitis model also con rmed that the expression level of TNF-α was positively correlated with the degree of colitis [32]. TNF-α could trigger the phosphorylation of myosin light chain, destroy the intestinal barrier and tight junction proteins, and can up-regulate the expression of iNOS and COX-2, activate the NF-κB pathway and other in ammatory signals, and initiate the cascade of in ammation reaction, thus resulting in sustained damage to the intestinal mucosa [2]. COX-2 catalyzes the release of many kinds of PGs (such as PGE4) and leukotrienes by arachidonic acid 33].…”

Section: Ento-pb Regulated the Expression Of In Ammatory Cytokines Inmentioning

confidence: 86%

“…Many evidences indicated that cytokines TNF-α and IL-1β play important roles in intestinal in ammation and barrier dysfunction [31]. Elevated levels of TNF-α and IL-1β increase neutrophil in ltration, damage the intestinal barrier, and drive diarrhea symptoms of UC [2]. The mucosal biopsy of IBD patients and the acetic acid-induced rat colitis model also con rmed that the expression level of TNF-α was positively correlated with the degree of colitis [32].…”

Section: Ento-pb Regulated the Expression Of In Ammatory Cytokines Inmentioning

confidence: 93%

“…Characterized by intestinal mucosal damage, recurrence and remission of alternating mucosal in ammation, ulcerative colitis is an intestinal disease [1,2]. In addition to typical intestinal manifestations such as abdominal pain, diarrhea, mucus, pus, and bloody stool, it can also accompany with multiorgan and multisystem extraintestinal manifestations, thus seriously affecting the life and work of patients [3].…”

Section: Introductionmentioning

confidence: 99%

“…The damage to the intestinal mucosa causes microorganisms enter the lamina propria from lumen, which triggers an in ammatory response, thus leading to the overproduction of in ammatory cytokines, including TNF-α, IL-1β, and COX-2. These cytokines further exacerbate the damage of intestinal mucosa [2]. At present, UC clinical rst-line treatment drugs such as 5-ASA and steroid hormones can relieve clinical symptoms by inhibiting the production of pro-in ammatory cytokines and nitric oxide.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dynamic Evaluation of Compound Ento-PB for the Repair of Mucosal Ulcer in Dogs With Acetic Acid-induced Experimental Colitis 

Chen¹,

Zhao²,

Z³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Mucosal inflammation and ulcer play important roles in the pathogenesis of ulcerative colitis. As as traditional Chinese medicine compound composed of Periplaneta americana and Taraxacum mongolicum, Ento-PB is always prescribed for the treatment of ulcer and inflammatory diseases. As for the significant role of P. americana in terms of promoting mucosal healing, the compatibility of the anti-inflammatory drug T. mongolicum may enable Ento-PB to simultaneously play anti-inflammatory and promote mucosal healing effects on the treatment of UC. Therefore, this study aimed to evaluate the therapeutic potential and possible mechanism of Ento-PB for UC by establishing an acetic acid-induced colitis model in dogs.Methods: Preliminary identification to the chemical components of compound Ento-PB was carried out through high performance liquid chromatography. A cross-bred dogs model of acetic acid-induced ulcerative colitis was established to evaluate the efficacy of compound Ento-PB. The expression levels of inflammatory cytokines C-reactive protein (CRP), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-10 (IL-10) in plasma were measured by carrying out enzyme-linked immunosorbent assay (ELISA).Results: With the extension of treatment time, Ento-PB could effectively improve clinical symptoms of UC cross-bred dogs. Colonoscopy displayed that mucosal redness, swelling and congestion decreased gradually, and obviously repaired after mucosal injury. The intestinal texture was gradually clear, and the colonoscopy score gradually reduced. Histopathological examination revealed that the structure of colon was restored significantly, the infiltration of inflammatory cells was reduced, and the histological score was remarkably reduced. At the same time, the results of dynamic monitoring of inflammatory cytokines in plasma proved that Ento-PB can gradually down-regulate the activity of CRP, iNOS and COX-2, reduce the expression levels of inflammatory cytokines TNF-α and IL-1β, and gradually restore anti-inflammatory and the expression level of cytokine IL-10.Conclusions: Ento-PB reduces the level of pro-inflammatory cytokines in a dose- and time-dependent manner and inflammation, improves colon tissue lesions and the repair of intestinal mucosa after injury, and effectively increases acetic acid-induced colon inflammation in UC cross-bred dogs.

show abstract

Rosa laevigata Polysaccharides Ameliorate Dextran Sulfate Sodium‐Induced Ulcerative Colitis of Beagles through Regulating Gut Microbiota

Peng,

Lu,

Lin

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

Rosa laevigata Michx. polysaccharides (RLP) have been demonstrated to possess antioxidant and anti‐inflammatory properties. However, the mechanisms and efficacy of these polysaccharide components in preventing ulcerative colitis (UC) remain to be elucidated. The efficacy and mechanisms of RLP were investigated in a study that utilized healthy adult beagles to establish a UC model, considering the similarities in gut microbiota between humans and dogs. In the study, the beagle model induced by sodium dextran sulfate exhibited typical symptoms of ulcerative colitis, such as weight loss and diarrhea. All these symptoms and changes were significantly ameliorated through oral supplementation of RLP. Additionally, microbial community analysis based on the 16S rDNA gene revealed that RLP alleviated UC by increasing the abundance of beneficial bacteria and reducing the abundance of harmful bacteria. In conclusion, our study has provided that RLP effectively alleviated colitis by preserving the intestinal barrier and regulating the gut microbiota composition.

show abstract

Ficus caricapolysaccharide attenuates DSS-induced ulcerative colitis in C57BL/6 mice

Abstract: FCPS effectively alleviates DSS-induced colitis, possibly via its beneficial effects on reshaping the gut microbiome and enhancing the formation of SCFAs.

Cited by 72 publications

References 68 publications

Role of Short Chain Fatty Acids and Apolipoproteins in the Regulation of Eosinophilia-Associated Diseases

Role of Short Chain Fatty Acids and Apolipoproteins in the Regulation of Eosinophilia-Associated Diseases

Dynamic Evaluation of Compound Ento-PB for the Repair of Mucosal Ulcer in Dogs With Acetic Acid-induced Experimental Colitis

Rosa laevigata Polysaccharides Ameliorate Dextran Sulfate Sodium‐Induced Ulcerative Colitis of Beagles through Regulating Gut Microbiota

Contact Info

Product

Resources

About

Ficus caricapolysaccharide attenuates DSS-induced ulcerative colitis in C57BL/6 mice

Abstract: FCPS effectively alleviates DSS-induced colitis, possibly via its beneficial effects on reshaping the gut microbiome and enhancing the formation of SCFAs.

Cited by 72 publications

References 68 publications

Role of Short Chain Fatty Acids and Apolipoproteins in the Regulation of Eosinophilia-Associated Diseases

Role of Short Chain Fatty Acids and Apolipoproteins in the Regulation of Eosinophilia-Associated Diseases

Dynamic Evaluation of Compound Ento-PB&nbsp;for the Repair of Mucosal Ulcer in Dogs With Acetic Acid-induced Experimental Colitis&nbsp;

Rosa laevigata Polysaccharides Ameliorate Dextran Sulfate Sodium‐Induced Ulcerative Colitis of Beagles through Regulating Gut Microbiota

Contact Info

Product

Resources

About

Dynamic Evaluation of Compound Ento-PB for the Repair of Mucosal Ulcer in Dogs With Acetic Acid-induced Experimental Colitis