<i>FGB</i>Gene − 148C&gt;T Polymorphism Is Associated with Increased Risk of Ischemic Stroke in a Chinese Population: A Meta-Analysis Based on 18 Case–Control Studies

Zhang, Lijun; Li, Hehua; Tao, Sheng-Bo; Yuan, Bin; Yan, Haiying; Chang, Li; Zhao, Jianhua

doi:10.1089/gtmb.2013.0501

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…Our results showed a tendency of a higher frequency of the β-fibrinogen CT genotype (c.-148C>T SNP) in patients with total and arterial thrombosis than in non BCR - ABL MPN patients who did not experience vascular events. The effect of this SNP was evaluated in a large population of Chinese patients with ischemic stroke and cerebral infarction, but not in non BCR - ABL MPNs [ 27 , 28 ]. There was also evidence that β-fibrinogen c.-148C>T SNP is functional and associated with elevated plasma fibrinogen levels [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Genetic polymorphisms of hemostatic factors and thrombotic risk in non BCR-ABL myeloproliferative neoplasms: A pilot study

Dambrauskienė

Gerbutavičius

Ugenskienė

et al. 2017

Balkan Journal of Medical Genetics

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The most important complications of Philadelphianegagive (non BCR-ABL) myeloproliferative neoplasms (MPNs) are vascular events. Our aim was to evaluate the effects of single nucleotide polymorphisms (SNPs), platelet glycoproteins (GPs) (Ia/IIa, Ibα, IIb/IIIa and VI), von Willebrand factor (vWF), coagulation factor VII (FVII), β-fibrinogen, and the risk of thrombosis in patients with non BCR-ABL MPNs at the Lithuanian University of Health Sciences. Kaunas, Lithuania. Genotyping was done for 108 patients. The TT genotype of the GP Ia/IIa c.807C>T polymorphism was more frequently found in the group of MPN patients with arterial thrombosis compared to MPN patients who were thrombosis-free [26.5 vs. 11.5%, p = 0.049; odds ratio (OR) 2.68; 95% confidence interval (95% CI) 1.01-7.38]. The CT genotype of the β-fibrinogen c.-148C>T polymorphism occurred more frequently in MPN patients with arterial, and total thrombosis compared to the wild or homozygous genotype (57.7 vs. 40.0 vs. 12.5%; p = 0.027), (64.7 vs. 44.4 vs. 25%; p = 0.032), respectively. The carrier state for the c.-323P10 variant of FVII SNP (summation of P10/10 and P0/10) was more frequent in MPN patients with thrombosis compared to the wild-type genotype carriers (71.4 vs. 43.4%; p = 0.049; OR 3.26; 95% CI 1.01-11.31). The coexistence of heterozygous β-fibrinogen c.-148C>T and FVII c.-323P0/10 SNP, increased the risk of arterial thrombosis (21.1 vs. 3.7%, p = 0.008; OR 6.93; 95% CI 1.38-34.80). The TT genotype of GP Ia/IIa c.807C>T, the CT genotype of β-fibrinogen c.-148C>T and FVII c.-323P0/10 SNP could be associated with risk of thrombosis in MPN patients.

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Section: Discussionmentioning

confidence: 99%

Genetic polymorphisms of hemostatic factors and thrombotic risk in non BCR-ABL myeloproliferative neoplasms: A pilot study

Dambrauskienė

Gerbutavičius

Ugenskienė

et al. 2017

Balkan Journal of Medical Genetics

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Potential key genes for predicting risk of stroke occurrence: A computational approach

Das

Kumar

2022

Neuroscience Informatics

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Thrombophilia as a reason for the development of ischemic stroke at young age. Features of the clinic and diagnosis

Savchuk,

Melnichenko,

Kurtadzhieva

et al. 2024

Gematologiâ i transfuziologiâ

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Introduction. Thrombophilia is a common cause of neurological complications.Aim. to present a clinical observation of the development of ischemic stroke in a patient with hereditary thrombophilia.Main findings. A case is presented of a man, aged 30, who developed an ischemic stroke in the basin of the left medial artery. A diagnostic study revealed that the development of the ischemic stroke was facilitated by thrombophilia caused by a combination of polymorphic variants of the fibrinogen genes (G-455A(G-467A)) and methylenetetrahydrofolate reductase (C677T). Thus, hereditary thrombophilia was a risk factor for the development of ischemic stroke in the patient at a young age. Therefore, in the absence of traditional risk factors for the development of ischemic stroke, a genetic analysis for thrombophilia is necessary.

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FGBGene − 148C>T Polymorphism Is Associated with Increased Risk of Ischemic Stroke in a Chinese Population: A Meta-Analysis Based on 18 Case–Control Studies

Abstract: The results of our meta-analysis suggested that the-148C>T polymorphism in the FGB gene is a susceptibility marker of ischemic stroke.

Cited by 3 publications

References 11 publications

Genetic polymorphisms of hemostatic factors and thrombotic risk in non BCR-ABL myeloproliferative neoplasms: A pilot study

Genetic polymorphisms of hemostatic factors and thrombotic risk in non BCR-ABL myeloproliferative neoplasms: A pilot study

Potential key genes for predicting risk of stroke occurrence: A computational approach

Thrombophilia as a reason for the development of ischemic stroke at young age. Features of the clinic and diagnosis

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