2005
DOI: 10.1111/j.1349-7006.2005.00007.x
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EPHA2/EFNA1 expression in human gastric cancer

Abstract: The erythropoietin-producing hepatocellular (EPH)A2 receptor, tyrosine kinase, is overexpressed and phosphorylated in several types of human tumors and has been associated with malignant transformation. A recent report, however, indicated that stimulation of the EPHA2 receptor ligand, ephrinA1 (EFNA1), inhibits the growth of EPHA2-expressing breast cancer. The authors examined the expression of EPHA2 and EFNA1 using semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) in four gastric cance… Show more

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Cited by 124 publications
(110 citation statements)
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“…The Eph family was initially known as a putative oncogene based on their overexpression in certain types of human cancers. The EphA2 receptor is overexpressed in colorectal, 24 gastric, 25 ovarian, 11 and esophageal squamous-cell carcinoma. 26 The EphA4 receptor is overexpressed in pancreatic ductal adenocarcinoma, 27 and Ephrin B1 is overexpressed in ovarian carcinoma.…”
Section: Discussionmentioning
confidence: 99%
“…The Eph family was initially known as a putative oncogene based on their overexpression in certain types of human cancers. The EphA2 receptor is overexpressed in colorectal, 24 gastric, 25 ovarian, 11 and esophageal squamous-cell carcinoma. 26 The EphA4 receptor is overexpressed in pancreatic ductal adenocarcinoma, 27 and Ephrin B1 is overexpressed in ovarian carcinoma.…”
Section: Discussionmentioning
confidence: 99%
“…These receptor-ligand systems are involved in cell-cell repulsion and attraction and play a role in tissue patterning, neuronal targeting, and angiogenesis during embryonic development (17)(18)(19)(20). In addition, EphA2 overexpression has been reported in many cancers including those of the breast, lung, esophagus, stomach, cervix, ovary, colon, prostate, kidney, and skin (21)(22)(23)(24)(25)(26)(27)(28)(29). Overexpression of EphA2 has been correlated with increased metastatic potential and decreased survival (22-24, 27, 29).…”
Section: Introductionmentioning
confidence: 99%
“…Generally, the upregulation of Eph/ ephrin has been reported in various types of cancer [7][8][9][10] . Overexpression of EphB2, ephrinB1, EphA2, and ephrinA1 has been reported in gastric cancer [11][12][13] . On the other hand, the concept that Eph receptors are oncogenes needs a new look on the basis of recent findings of downregulation of Eph receptors in certain types of cancer [14][15][16][17] .…”
mentioning
confidence: 99%