“…However, taking aim at the TPE as a mixture of environment-types (Podlich et al, 1999;Cooper et al, 2014a,b;Gaffney et al, 2015;Rogers et al, 2021;Smith et al, 2021a, b;Messina et al, 2022a,b) is much less common than taking aim at specific environment-types. Taking aim at the TPE requires detailed consideration of the mixture of target environment-types within the TPE (Chapman et al, 2000;Chenu et al, 2011;Kholová et al, 2013;Cooper et al, 2014a, b;Lobell et al, 2015;Hajjarpoor et al, 2021;Resende et al, 2021), the extent of GxE interactions between environment-types (Figure 2) and the details of the genetic variance-covariance structure among the environment-types, and appropriate attention to weighting the sources of G2P information for traits, that is available from the environment-types sampled in the MET training data sets, by their frequencies of occurrence and relative importance in the TPE (Podlich et al, 1999;Cooper et al, 2014a, b;Gaffney et al, 2015;Messina et al, 2018;Smith et al, 2021b).…”