Abstract:BackgroundThe precise formation of mineralized dental tissues such as enamel and/or dentin require tight transcriptional control of the secretion of matrix proteins. Here, we have investigated the transcriptional regulation of the second most prominent enamel matrix protein, enamelin, and its regulation through the major odontogenic transcription factor, MSX2.ResultsUsing in vitro and in vivo approaches, we identified that (a) Enam expression is reduced in the Msx2 mouse mutant pre‐secretory and secretory amel… Show more
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