<i>Emblica officinalis</i> Corrects Functional, Biochemical and Molecular Deficits in Experimental Diabetic Neuropathy by Targeting the Oxido‐nitrosative Stress Mediated Inflammatory Cascade

Tiwari, Vinod; Kuhad, Anurag; Chopra, Kanwaljit

doi:10.1002/ptr.3440

Cited by 66 publications

(37 citation statements)

References 56 publications

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“…The study conducted by Tiwari et al, demonstrated that E. officinalis extracts not only attenuated the diabetic condition but also reversed neuropathic pain through modulation of oxidative-nitrosative stress in diabetic rats. [33] Even Kumar et al, investigated flavonoid rich fruit extract of E. officinalis in type II diabetes induced diabetic neuropathy in male Sprague-Dawley rats. Treatment with E. officinalis extract (EOE) in diabetic rats displayed a significant increase in tail flick latency in hot immersion test and pain threshold level in hot plate test compared to control rats.…”

Section: Metabolic Syndromementioning

confidence: 98%

Emblica officinalis(Amla): A review of potential therapeutic applications

Bhandari¹,

Kamdod²

2012

Int J Green Pharm

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PHYTOCHEMISTRYE. officinalis is one of the most extensively studied plants and reports suggest that it contains tannins, alkaloids, and phenolic compounds. It has been reported that fruits of E. officinalis contains higher amount of vitamin C and considerably higher concentrations of most minerals, protein and amino acids like glutamic acid, proline, aspartic acid, alanine, cystine and lysine. vitamin C levels are more than those in oranges, tangerines, or lemons. Fresh pericarp of E. officinalis contains higher amount of hydrolysable tannins like emblicanin A and B, punigluconin, pedunculagin. Activity-directed fractionation and purification process identified phytochemicals present in E. officinalis. They have identified gallic acid, methyl gallate, corilagin, furosin and geraniin in E. officinalis by a chromatographic and spectroscopic method. Phytochemical investigations revealed that E. officinalis contains higher amount of flavonoid like quercetin. Fruits were also analyzed for their alkaloidal Emblica officinalis Gaertn. or Phyllanthus emblica Linn, commonly known as Indian gooseberry or Amla, is perhaps the most important medicinal plant in the Indian traditional system of medicine, the Ayurveda. Several parts of the plant are used to treat a variety of diseases, but the most important is the fruit. Many ailments are treated by the fruit which is used either alone or in combination with other plants. These include common cold and fever; as a diuretic, laxative, liver tonic, refrigerant, stomachic, restorative, alterative, antipyretic, anti-inflammatory, hair tonic; to prevent peptic ulcer and dyspepsia, and as a digestive. E. officinalis possesses antipyretic, analgesic, antitussive, antiatherogenic, adaptogenic, cardioprotective, gastroprotective, antianemic, antihypercholesterolemic, wound healing, antidiarrheal, antiatherosclerotic, hepatoprotective, nephroprotective, and neuroprotective properties as demonstrated in numerous preclinical studies. Furthermore, experimental studies have reported that E. officinalis and some of its phytochemicals also exhibit anticarcinogenic properties. E. officinalis is also reported to possess radiomodulatory, chemomodulatory, chemopreventive, free radical scavenging, antioxidant, anti-inflammatory, antimutagenic and immunomodulatory activities. These properties are efficacious in the treatment and prevention of cancer. This review summarizes the results related to these properties and also emphasizes the aspects that warrant future research establishing its activity and utility as a cancer preventive and therapeutic drug in humans.

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Section: Metabolic Syndromementioning

confidence: 98%

Emblica officinalis(Amla): A review of potential therapeutic applications

Bhandari¹,

Kamdod²

2012

Int J Green Pharm

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“…The latency to the first sign of paw licking or jump response to avoid the heat was taken as an index of the pain threshold; the cut off time was 10 s in order to avoid damage to the paw [39].…”

Section: Experimental Designmentioning

confidence: 99%

Tetrahydrocurcumin exerts protective effect on vincristine induced neuropathy: Behavioral, biochemical, neurophysiological and histological evidence

Greeshma¹,

Prasanth²,

Bhaskar³

2015

Chemico-Biological Interactions

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“…In this test, mice were individually placed on a hot plate (Eddy's hot plate) with the temperature adjusted to 55 ± 1 C. The latency to the first sign of paw licking or jump response to avoid the heat was taken as an index of the pain threshold; the cut-off time was 10 s in order to avoid damage to the paw (Tiwari et al, 2011).…”

Section: Hot Plate Test (Thermal Hyperalgesia)mentioning

confidence: 99%

Effect of curcumin in mice model of vincristine-induced neuropathy

Babu¹,

Prasanth²,

Bhaskar³

2014

Pharmaceutical Biology

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Context: Curcumin exhibits a wide spectrum of biological activities which include neuroprotective, antinociceptive, anti-inflammatory, and antioxidant activity. Objective: The present study evaluates the effect of curcumin in vincristine-induced neuropathy in a mice model. Materials and methods: Vincristine sulfate (0.1 mg/kg, i.p. for 10 consecutive days) was administered to mice to induce neuropathy. Pain behavior was assessed at different days, i.e., 0, 7, 10, and 14 d. Sciatic nerve total calcium, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), nitric oxide (NO), and lipid peroxidation (LPO) were also estimated after the 14th day of study. Pregabalin (10 mg/kg, p.o.) and curcumin (15, 30, and 60 mg/kg, p.o.) were administered for 14 consecutive days. Results: Curcumin at 60 mg/kg significantly attenuated the vincristine-induced neuropathic pain manifestations in terms of thermal hyperalgesia (p50.001) and allodynia (p50.001); mechanical hyperalgesia (p50.001); functional loss (p50.001); and in the delayed phase of formalin test (p50.001). Curcumin at 30 and 60 mg/kg exhibited significant changes (p50.001) in antioxidant levels and in total calcium levels in vincristine-injected mice. Conclusion: Curcumin at 30 and 60 mg/kg dose levels significantly attenuated vincristineinduced neuropathy which may be due to its multiple actions including antinociceptive, calcium inhibitory, and antioxidant effect.

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Emblica officinalis Corrects Functional, Biochemical and Molecular Deficits in Experimental Diabetic Neuropathy by Targeting the Oxido‐nitrosative Stress Mediated Inflammatory Cascade

Cited by 66 publications

References 56 publications

Emblica officinalis(Amla): A review of potential therapeutic applications

Emblica officinalis(Amla): A review of potential therapeutic applications

Tetrahydrocurcumin exerts protective effect on vincristine induced neuropathy: Behavioral, biochemical, neurophysiological and histological evidence

Effect of curcumin in mice model of vincristine-induced neuropathy

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