<i>Effect of Exercise on Circulatory Dynamics of Normal Individuals</i>

Dexter, Lewis; Whittenberger, James L.; Haynes, Florence W.; Goodale, Walter T.; Gorlin, Richard; Sawyer, C.Glenn

doi:10.1152/jappl.1951.3.8.439

Cited by 216 publications

(52 citation statements)

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“…These are shown in Table II (Riley et al, 1948;Hickam and Cargill, 1948;Dexter et al, 1951;Lewis et al, 1952;Slonim et al, 1954;Donald et al, 1955;Freedman et al, 1955;Barratt-Boyes and Wood, 1957).…”

Section: Resultsmentioning

confidence: 99%

Ventilation and haemodynamics in heart disease.

Gazetopoulos¹,

Davies²,

Oliver³

et al. 1966

Heart

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Section: Resultsmentioning

confidence: 99%

Ventilation and haemodynamics in heart disease.

Gazetopoulos¹,

Davies²,

Oliver³

et al. 1966

Heart

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“…A normal response, as observed in our control group, should have been a small increase as reported unaniMOusly. 13 15,18,21,23,30 In patients with medium or large shunts, however, Q, determinations and thus estimation of stroke volume may have been inaccurate because only one sample of blood from the right atrium was used for determining oxygen content in mixed venous blood.3' However, this problem is of minor importance in group 1 subjects who had closed or minor defects. Furthermore, only marginal differences between exercise right atrial and pulmonary arterial oxygen saturations were observed in the control group (mean 2% units, range 0 to 3).…”

Section: Discussionmentioning

confidence: 99%

Hemodynamic findings at rest and during mild supine exercise in adults with isolated, uncomplicated ventricular septal defects.

Otterstad¹,

Simonsen²,

Erikssen³

1985

Circulation

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Fifty-two patients with isolated congenital ventricular septal defects (VSDs), studied for the first time at age 10 or older, were restudied an average of 16 years later (range 4 to 2 1 ). The than a left-to-right shunting7 8 at the ventricular level, as evidenced, for example, by a high incidence of valvular lesions. It was also observed that even in subjects with small shunts, normal pulmonary arterial pressure, and absence of complicating valvular disease, a subnormal physical performance was often observed. This finding provides the rationale for the present study of hemodynamics at rest and during mild supine exercise. The main objective was to assess whether this subnormal physical performance could be related to the fear of having a congenital heart disease.

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“…Dexter and co-workers (13) found that light leg exercise while the subject was supine increased the average stroke index from 41 to 51 ml in a group of seven healthy adults. Barratt-Boyes and Wood (10) noted an average increase from 49 to 59 ml with comparable leg exercise in 11 adults.…”

Section: Fig 3 Changes In Stroke Volume and Cardiac Output In Each mentioning

confidence: 96%

The Effect of Changes in Posture and of Graded Exercise on Stroke Volume in Man *

Wang¹,

Marshall²,

Shepherd³

1960

J. Clin. Invest.

193

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Interest has been revived recently in the relative importance of changes in heart rate and stroke volume during exercise in man. Rushmer and Smith have examined the literature and concluded that an increase in stroke volume is not an essential feature of the ventricular response in normal human subjects (1, 2). Contrary views, particularly in the older literature, were attributed to differences in the technics used to measure cardiac output and in the degree of training of the subjects (1). However, in the studies reviewed by Rushmer, the subjects had exercised in various postures. This could have accounted for much of the apparent discrepancy (3), a point which Rushmer has now emphasized (4).The present investigation demonstrates the importance of the posture of the subject in the interpretation of changes in stroke volume from rest to exercise. The stroke volume increases only slightly once exercise has begun, regardless of the severity of the exercise or the position assumed by the subject. METHODSSeven healthy "untrained" men, aged 25 to 35 years, were studied. Cardiac output was measured by the indicator-dilution method. A cardiac catheter was placed with its tip in the superior vena cava. The indicator, cardio-green dye,1 was given in a dose of 7.5 mg by sudden injection from a specially calibrated syringe. The syringe was attached to the catheter throughout the experiment and was filled before each injection from a supply syringe connected to it by a three-way tap. Blood was sampled continuously for each dilution curve from the radial artery through a Wood oximeter at * This investigation was supported in part by a grant from the Minnesota Heart Association. rates of 28 to 50 ml per minute. The dilution curve was recorded on a photokymograph. Not more than 40 ml was withdrawn for any curve. On completion of each curve the blood was reinfused.Samples of blood were withdrawn from the radial artery before and after each experiment. Known amounts of dye were added to 10 ml aliquots of blood and the resulting mixtures were drawn through the cuvet oximeter to permit calibration of tIle dilution curves. The calibrations for the two samples invariably were close (Figure 1, upper panel) and were reproducible from day to day. Calibrations for blood from different subjects were similar. Figure 1

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Effect of Exercise on Circulatory Dynamics of Normal Individuals

Cited by 216 publications

References 0 publications

Ventilation and haemodynamics in heart disease.

Ventilation and haemodynamics in heart disease.

Hemodynamic findings at rest and during mild supine exercise in adults with isolated, uncomplicated ventricular septal defects.

The Effect of Changes in Posture and of Graded Exercise on Stroke Volume in Man *

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