(<i>E</i>)-3-([2,2’-bithiophen]-5-yl)-1-(4-fluorophenyl)prop-2-en-1-one: Synthesis and structural elucidation of chalcone derivatives for potential antioxidant activity

Rajasagaran, R.; Arshad, Ahmad Saifuddin Mohamad; Azizi, Juzaili; Nizar, Siti Nabilla Aliya Mohd; Arshad, Suhana

doi:10.1080/15421406.2022.2156161

Cited by 2 publications

(1 citation statement)

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“…However, recent synthesis involving solid and functionalized reactants have generally used simple alcohols as solvents. Chalcones have demonstrated various biological activities including antioxidants, [3–5] anticancer, [6–8] antidiabetic, [9–11] antiviral, [12–14] antimalarial, [15–17] and many more. Aside the biological properties of chalcones, they have been employed in chemical industries as fluorescent active materials, [18–20] corrosion inhibitors, [21–24] and in the synthesis of liquid crystals [25–28] .…”

Section: Introductionmentioning

confidence: 99%

Electrochemical and Theoretical Modelled Reduction of β‐Diketone Inspired Chalcones

Izuchukwu Ugwu,

Conradie

2024

ChemistrySelect

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The growing interest in synthesizing electrochemically active organic ligands stems from extensive reports highlighting the applications of redox‐active organic molecules. These molecules play a crucial role in capturing and converting CO2 into valuable organic compounds, including carbonates used as solvents in lithium batteries. In this study, we present an electrochemical investigation of two chalcone derivatives, referred to as (1) and (2). We explored the influence of different solvent systems, specifically acetonitrile and dimethyl sulfoxide, on the reduction potential of these chalcones. The reported chalcone derivatives were characterized using various analytical techniques, including UV/Visible spectroscopy, Fourier Transform Infrared spectroscopy, Proton and Carbon‐13 nuclear magnetic resonance, as well as mass spectrometry. The characterization of the reported chalcones, exhibiting properties of both β‐diketones and 2‐hydroxyphenones, is underscored by a density functional theory (DFT) study of chalcones (1) and (2). This research establishes a correlation between the energies calculated through DFT and the experimental reduction potentials of chalcones (1) and (2), in comparing them with a series of β‐diketones and 2‐hydroxyphenones.

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